Formulation and Evaluation of Prulifloxacin Sustained Release Matrix Tablets

  • V. Phani Deepthi Department of Pharmaceutics, JNTUA -Oil Technological and Pharmaceutical Research Institute, Anantapuramu, A.P, India
  • AMPAPURAM RAJESH PAVAN Department of Pharmaceutics, JNTUA -Oil Technological and Pharmaceutical Research Institute, Anantapuramu, A.P, India
  • G. Naresh Babu Department of Pharmaceutics, Balaji College of pharmacy, Ananthapuramu, AP, India.
  • K. Sreenivasulu Department of Pharmaceutics, Creative Educational Society’s College of Pharmacy, Kurnool, AP, India.

Abstract

Prulifloxacin is a chemotherapeutic antibiotic of Fluor quinolone drug used to treat a various urinary tract infections. It has short half-life, makes the sustained release (SR) forms extremely advantageous. Sustained release tablets results in increased bioavailability. The purpose of the present study was to develop a sustain release matrix drug delivery system (SR) containing Prulifloxacin as a model drug by using various proportions of polymers such as HPMC E15, HPMC K15. The sustained release formulations of Prulifloxacin were prepared by direct compression method. Optimization of formulation was done by studying effect of drug to polymer ratio on drug release. FT-IR studies indicated absence of any interaction between Prulifloxacin, polymers (HPMC E15 and HPMC K15) and excipients. Ten formulations were prepared and Formulation F8 possesses good drug release property. The tablets were also evaluated for its hardness, friability and other In-vitro evaluation tests. All parameters complied with IP limits. Drug release was diffusion controlled and followed Zero order kinetics. Non-Fickian diffusion was the drug release mechanism for all the tablets formulated.


Keywords: Sustained drug delivery system, Prulifloxacin, HPMCE15, HPMCK15

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Author Biographies

V. Phani Deepthi, Department of Pharmaceutics, JNTUA -Oil Technological and Pharmaceutical Research Institute, Anantapuramu, A.P, India

Department of Pharmaceutics, JNTUA -Oil Technological and Pharmaceutical Research Institute, Anantapuramu, A.P, India

AMPAPURAM RAJESH PAVAN, Department of Pharmaceutics, JNTUA -Oil Technological and Pharmaceutical Research Institute, Anantapuramu, A.P, India

Department of Pharmaceutics, JNTUA -Oil Technological and Pharmaceutical Research Institute, Anantapuramu, A.P, India

G. Naresh Babu, Department of Pharmaceutics, Balaji College of pharmacy, Ananthapuramu, AP, India.

Department of Pharmaceutics, Balaji College of pharmacy, Ananthapuramu, AP, India.

K. Sreenivasulu, Department of Pharmaceutics, Creative Educational Society’s College of Pharmacy, Kurnool, AP, India.

Department of Pharmaceutics, Creative Educational Society’s College of Pharmacy, Kurnool, AP, India.

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How to Cite
Deepthi, V. P., PAVAN, A., Babu, G. N., & Sreenivasulu, K. (2019). Formulation and Evaluation of Prulifloxacin Sustained Release Matrix Tablets. Journal of Drug Delivery and Therapeutics, 9(4), 72-81. https://doi.org/10.22270/jddt.v9i4.2974