Formulation and Evaluation of Herbal Extract of Allivum sativum (Garlic) Loaded Chitosan Nanoparticles
Abstract
The present study aim to get novel approach of herbal chitosan nanoparticle to get improved efficacy of the drug with a less side effect. The present study include formulation and evaluation of chitosan loaded nanoparticle of Allivum sativum by using ionic gelation method. In present study five different formulations were prepared by using the different ratio of polymer and TPP. The prepared nanoparticle was evaluated for its particle size, zeta potential, scanning electron microscopy (SEM), production yield, encapsulation efficiency (EE), stability and in-vitro drug release. The optimized Allivum sativum extract loaded chitosan nanoparticle was found with production yield of 73.59%. They were found round shape and with smooth surface. The in-vitro release profile sustained up to 90.65 %. Thus results have found F1 formulation was more stable. It showed highest in-vitro drug release. So it was found that F1 was best formulation among the all batches prepared. This formulation can be further use to treat disease like cancer.
Keywords: Chitosan nanoparticle, SEM, Allivum sativum, Anti-cancer activity, Chemotherapy
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References
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11. Sethi N, Kaura S, Dilbaghi N, Parle M and Pal M, Garlic: a pungent wonder from nature, international research journal of pharmacy, 2014; 5(7):523-529.
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13.Agarwal N, Majee C, Chakra Borthy G.S , Natural Herbs as Anticancer Drugs, International Journal of Pharm Tech Research, 2012; 4(3):1142-1153.
14. Touri Samira Hassanzadeh, Bayat Mansour, Mohsenifar Afshin, Haghighat Setareh, Evaluation of the Antimicrobial Effects of Nano-Essences of Allium sativum L., Thymus vulgaris L., Menthapiperita L., and Chamaemelum nobile L. on Common Causes of Otitis Externa, Avicenna Journal of Clinical Microbiology and Infection, 2018;5(2):1-6.
15. Quazi MA, molvi KI, A review article on managent of cancer with herbal remedies, international journal for pharmaceutical research scholars, 2014; 3(3).
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17. Slman Dhuha Kadhem, Dhyea Raghad Jalill Abdul, N Ahmed. Abd, Biosynthesis of zinc oxide nanoparticles by hot aqueous extract of Allium sativum plants, J. Pharm. Sci. & Res,2018; 10(6):1590-1596.
18. Agarwal M, Agarwal MK, Srivastava N, Pandey S, Das R, Gaur P, Preparation of Chitosan Nanoparticles and their In-vitro Characterization, International journal of life science scientific research,2018;4(2):1713-1720.
19. Supriya A, Sundaraseelan J, BR Srinivas Murthy and M Bindu Priya, Acta, Formulation and In-vitro Characterization of Neomycin Loaded Chitosan Nanoparticles, Scientific Pharmaceutical Sciences, 2018; 2(2):34-40.
20. Jayandran M, Muhamed Haneefa M, Balasubramanian V, Green synthesis and characterization of Manganese nanoparticles using natural plant extracts and its evaluation of antimicrobial activity, Journal of Applied Pharmaceutical Science, 2015; 5 (12):105-110.
2. Thapliyal A, Khar RK, Chandra A, Overview of Cancer and Medicinal Herbs used for Cancer Therapy,2018; 12(1):1-8.
3. Priya. M. Lakshmi., bhanu priya. K. venkata subbaiah kotakadi and jostna. P, herbal and medicinal plants molecules towards treatment of cancer: A mini review: American journal of ethno medicine, 2015; 2(2):136-142.
4. Tiruwa R, A review on nanoparticles–preparation and evaluation parameters Indian J.Pharm.Biol.Res. 2015; 4(2):27-31.
5. Aljebory Abdulhussien M. & Alsalman Tamadhur M., Chitosan Nanoparticles: Review Article, Imperial Journal of Interdisciplinary Research, 2017; 3(7):233-242.
6. Lanka D, Mitta pally VK, Preparation and Applications of Chitosan Nanoparticles: A Brief Review: Research and Reviews: Journal of Material Science, 2016; 10(4172):2321-6212.
7. Akhila Rajan, S.T Gopukumar., and P.K Praseetha, Chitosan nanoparticle for drug delivery – a mini review, Journal of Global Trends in Pharmaceutical Sciences, 2017; 8(3):4181-4190.
8. Aruna U, Rajalakshmi R, Indira Muzib Y, Vinesha V, Sushma M, Vandana KR, Vijay Kumar N, Role of Chitosan Nanoparticles in Cancer Therapy, International Journal of Innovative Pharmaceutical Research. 2013, 4(3):318-324.
9. Qi Lifeng, XuZirong, Jiang Xia, Hu Caihong and ZouXiangfei Preparation and antibacterial activity of chitosan nanoparticles Carbohydrate Research,2004; 339(16);2693–2700.
10. Alam Sanjar, Katiyar Deepti , Goel Richa, Vats Amita, Mittal Ashu, Role of herbals in cancer management, The Journal of Phyto pharmacology 2013; 2(6):46-51.
11. Sethi N, Kaura S, Dilbaghi N, Parle M and Pal M, Garlic: a pungent wonder from nature, international research journal of pharmacy, 2014; 5(7):523-529.
12. Alam S, Katiyar D, goel R, vats A, Mitta A, role of herbals in cancer management, the journal of phyto pharmacology, 2013; 2(6):46-51.
13.Agarwal N, Majee C, Chakra Borthy G.S , Natural Herbs as Anticancer Drugs, International Journal of Pharm Tech Research, 2012; 4(3):1142-1153.
14. Touri Samira Hassanzadeh, Bayat Mansour, Mohsenifar Afshin, Haghighat Setareh, Evaluation of the Antimicrobial Effects of Nano-Essences of Allium sativum L., Thymus vulgaris L., Menthapiperita L., and Chamaemelum nobile L. on Common Causes of Otitis Externa, Avicenna Journal of Clinical Microbiology and Infection, 2018;5(2):1-6.
15. Quazi MA, molvi KI, A review article on managent of cancer with herbal remedies, international journal for pharmaceutical research scholars, 2014; 3(3).
16. Chandirika J. Uthaya, R. Sindhu, S. Selvakumar, G. Annadurai, herbal extract encapsulated in chitosan nanoparticle: A novel strategy for the treatment of urolithiasis, indo American general of pharmaceutical science, 2018; 5(03):1955-1961.
17. Slman Dhuha Kadhem, Dhyea Raghad Jalill Abdul, N Ahmed. Abd, Biosynthesis of zinc oxide nanoparticles by hot aqueous extract of Allium sativum plants, J. Pharm. Sci. & Res,2018; 10(6):1590-1596.
18. Agarwal M, Agarwal MK, Srivastava N, Pandey S, Das R, Gaur P, Preparation of Chitosan Nanoparticles and their In-vitro Characterization, International journal of life science scientific research,2018;4(2):1713-1720.
19. Supriya A, Sundaraseelan J, BR Srinivas Murthy and M Bindu Priya, Acta, Formulation and In-vitro Characterization of Neomycin Loaded Chitosan Nanoparticles, Scientific Pharmaceutical Sciences, 2018; 2(2):34-40.
20. Jayandran M, Muhamed Haneefa M, Balasubramanian V, Green synthesis and characterization of Manganese nanoparticles using natural plant extracts and its evaluation of antimicrobial activity, Journal of Applied Pharmaceutical Science, 2015; 5 (12):105-110.
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1.
Gupta DK, Kesharwani S, Sharma N, Gupta MK. Formulation and Evaluation of Herbal Extract of Allivum sativum (Garlic) Loaded Chitosan Nanoparticles. JDDT [Internet]. 22Jun.2019 [cited 3Jun.2020];9(3-s):715-8. Available from: http://jddtonline.info/index.php/jddt/article/view/2963
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