Formulation and Characterization of Mouth Dissolving Tablet of Antiepileptic Drug using Natural Superdisintegrants

  • Lavika Gandhi Shri Ram Murti Smarak College of Engineering & Technology (Pharmacy), Bareilly (U.P) India
  • Md. Semimul Akhtar Shri Ram Murti Smarak College of Engineering & Technology (Pharmacy), Bareilly (U.P) India

Abstract

MDTs is regarding as a good candidates for the patients with persistent nausea, who are traveling, or who have little or no access to water.  The objective of present research work was to prepare and evaluate the mouth dissolving tablet of Lacosamide using Super disintegrants like Guar Gum, and other excipients like Microcrystalline Cellulose and Mannitol in different concentrations by Direct Compression method. Lacosamide has been shown to be an effective antiepileptic agent appropriate for the epilepsy patients. Effect of different formulation variables i.e. amount of polymer and type of polymer was studied on release profile and other characteristics. The mouth dissolving tablets were prepared by single punch machine using powder blend of superdisintegrant and Lacosamide. Post-compression parameters like Hardness, weight variation, friability, In-Vitro dispersion, Drug content uniformity and In-vitro drug release studies were carried out for all the formulation. All the Formulations gave the result within the official limits. The prepared mouth dissolving tablet shows the properties of fast disintegration time (28 sec to 47 sec) within official limit.  By the in-vitro disintegration, it is concluded that formulation F2 prepared by Guar Gum (10%) showed the fast disintegration time than the MCC. Therefore, it may be concluded that mouth dissolving tablet was suitable choice for delivery system of Lacosamide.


Keywords: Lacosamide, Mouth dissolving tablets, Superdisintegrants, Guargum, microcrystalline cellulose, Direct compression method, Antiepileptic drug.

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Author Biographies

Lavika Gandhi, Shri Ram Murti Smarak College of Engineering & Technology (Pharmacy), Bareilly (U.P) India

Shri Ram Murti Smarak College of Engineering & Technology (Pharmacy), Bareilly (U.P) India

Md. Semimul Akhtar, Shri Ram Murti Smarak College of Engineering & Technology (Pharmacy), Bareilly (U.P) India

Shri Ram Murti Smarak College of Engineering & Technology (Pharmacy), Bareilly (U.P) India

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How to Cite
Gandhi, L., & Akhtar, M. S. (2019). Formulation and Characterization of Mouth Dissolving Tablet of Antiepileptic Drug using Natural Superdisintegrants. Journal of Drug Delivery and Therapeutics, 9(3-s), 673-678. https://doi.org/10.22270/jddt.v9i3-s.2950