Protective role of Carica papaya and Ficus bengalensis latex against CCl4 induced liver toxicity in experimental rats

  • Yogendra Kumar Research Scholar, Faculty of Pharmacy, Bhagwant University, Sikar Road, Ajmer, Rajasthan, India
  • Girendra Gautam Faculty of Pharmacy, Bhagwant University, Sikar Road, Ajmer, Rajasthan, India
  • Pushpesh Kumar Mishra Department of Chemistry, Faculty of Pharmacy, Naraina Group of Institutions, Kanpur, U.P., India

Abstract

Objective: To study the hepatoprotective activity of  Carica Papaya Latex at the  dose 400mg/kg/b.w. per oral and Ficus Bengalensis latex at dose 300mg/kg/b.w. per oral  against CCl4  induce Hepatotoxicity in albino rats.


Method: Animals were divided into 5 groups of 6 animals in each group.


Group I – Served as a normal control received saline 1ml /Kg for 21 days. The group -II, III, IV and V animals were received CCl4 at dose 1ml/Kg b.w./day  intra- peritoneally. Animals from group –III to V received Carica Papaya Latex (400mg/Kg.p.o.), Ficus Bengalensis Latex (300mg/Kg.p.o.) and standard drug Silymarin (30mg/Kg.p.o.) once daily for 21 days.  All groups animals were sacrificed on 22 days under light ether anesthesia  . Blood sample were collected and used for bio-chemical parameters like serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), Bilirubin(BRN), Alkaline phosphate (ALP) and total protein.


Result:The results were observed that  Carica Papaya latex at dose 400 mg/kg.b.w and CCl4  treated group , Ficus Bengalensis latex at dose 300 mg/kg.B.w and CCl4  treated groups were found the decreased levels of SGPT,SGOT,, ALP and Bilirubin  and increased total protein level compare to CCl4 treated group .So that this  study indicated hepatoprotective effect .


Conclusion: Present investigation indicated that both latex of Carica papaya and Ficus Bengalensis showed significant protection against CCl4 nduced hepatotoxicity in Rats.


Keywords: Carica Papaya, Ficus Bengalensis, Hepatoprotective, Carbon Tetra Chloride, Silymarin.

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Author Biographies

Yogendra Kumar, Research Scholar, Faculty of Pharmacy, Bhagwant University, Sikar Road, Ajmer, Rajasthan, India

Research Scholar, Faculty of Pharmacy, Bhagwant University, Sikar Road, Ajmer, Rajasthan, India

Girendra Gautam, Faculty of Pharmacy, Bhagwant University, Sikar Road, Ajmer, Rajasthan, India

Faculty of Pharmacy, Bhagwant University, Sikar Road, Ajmer, Rajasthan, India

Pushpesh Kumar Mishra, Department of Chemistry, Faculty of Pharmacy, Naraina Group of Institutions, Kanpur, U.P., India

Department of Chemistry, Faculty of Pharmacy, Naraina Group of Institutions, Kanpur, U.P., India

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How to Cite
Kumar, Y., Gautam, G., & Mishra, P. K. (2019). Protective role of Carica papaya and Ficus bengalensis latex against CCl4 induced liver toxicity in experimental rats. Journal of Drug Delivery and Therapeutics, 9(3), 465-469. https://doi.org/10.22270/jddt.v9i3.2936