Protective role of Carica papaya and Ficus bengalensis latex against CCl4 induced liver toxicity in experimental rats
Objective: To study the hepatoprotective activity of Carica Papaya Latex at the dose 400mg/kg/b.w. per oral and Ficus Bengalensis latex at dose 300mg/kg/b.w. per oral against CCl4 induce Hepatotoxicity in albino rats.
Method: Animals were divided into 5 groups of 6 animals in each group.
Group I – Served as a normal control received saline 1ml /Kg for 21 days. The group -II, III, IV and V animals were received CCl4 at dose 1ml/Kg b.w./day intra- peritoneally. Animals from group –III to V received Carica Papaya Latex (400mg/Kg.p.o.), Ficus Bengalensis Latex (300mg/Kg.p.o.) and standard drug Silymarin (30mg/Kg.p.o.) once daily for 21 days. All groups animals were sacrificed on 22 days under light ether anesthesia . Blood sample were collected and used for bio-chemical parameters like serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), Bilirubin(BRN), Alkaline phosphate (ALP) and total protein.
Result:The results were observed that Carica Papaya latex at dose 400 mg/kg.b.w and CCl4 treated group , Ficus Bengalensis latex at dose 300 mg/kg.B.w and CCl4 treated groups were found the decreased levels of SGPT,SGOT,, ALP and Bilirubin and increased total protein level compare to CCl4 treated group .So that this study indicated hepatoprotective effect .
Conclusion: Present investigation indicated that both latex of Carica papaya and Ficus Bengalensis showed significant protection against CCl4 nduced hepatotoxicity in Rats.
Keywords: Carica Papaya, Ficus Bengalensis, Hepatoprotective, Carbon Tetra Chloride, Silymarin.
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