Novel Strategy: Microsponges for Topical Drug Delivery
Microsponge delivery system is a unique and effective technology for the controlled release of topical agents. It is highly cross- linked porous, polymeric microspheres that can entrap wide range of active agents and in response to trigger or stimuli and release them onto the skin over a time. It consists of micro-porous beads, typically 5-300µm in diameter that acquire the flexibility to entrap a wide variety of active ingredients such as fragrances, sunscreens, emollients, anti-fungal, anti-infective, and anti-inflammatory agents etc., that are mostly used to prolong the topical administration of the drug . Recently it was investigated that microsponges also used for oral drug delivery system. The topical agent formulation with microsponge delivery system can be prepared in many different forms, such as cream, gel, or lotion. When the formulation is applied to the skin, the MDS releases its active ingredients on a time and in response to other stimuli (rubbing, temperature, pH etc.). They reduce side effects, enhance stability and modify drug release. Because of the size of the microsponges they cannot pass through the stratum corneum, so they remain on the skin surface and slowly releasing the active ingredients over a period. Slow rate of release from MDS reduce the irritancy associated with the topical agents. Slow and gradual release pattern of MDS prevents excessive build-up of the active agents in the epidermis and dermis. Therefore, these particles, remains on the surface of the skin and its fine lines delivering the active over prolonged time.
Keywords: Microsponge Delivery System, Quasi- emulsion solvent diffusion.
2. Jain Vikas and singh Ranjit. Dicyclomine-loaded eudragit based microsponge with potential for colonic delivery Preparation and characterization, Tropical Journal of Pharmaceutical Research, 2010; 9(1):67-72.
3. Kumari Pushpa, Mishra Shashi Kiran. A Comprehensive Review on Novel Microsponges Drug Delivery Approach, Asian Journal of Pharmaceutical and Clinical Research, 2016; 9(1):25-30.
4. Gupta Akashdeep, Dhyani Archana and Juyal Divya. Microsponges laden gels for topical delivery: A novel approach The Pharma Innovation Journal, 2016; 5(6): 39-43.
5. Kumar Jaya raja, Muralidharan Selvadurai and Parasuraman Subramani. Evaluation of Antifungal Activity of Sustained Release Microsponge Enriched Fluconazole Gel for Penile Candidiasis in Male Rats, International Journal of PharmTech Research, 2014; 6(6):1888-1897.
6. Avhad Pawan S. and Patil Prashant B. A New Era in Topical Formulations – Microsponge Drug Delivery System International Journal of Pharmaceutical Science and Research, 2016; 7(7):2756-2761.
7. Patel Archana, Upadhyay Pratik, Trivedi Jatin, Shah Shreeraj and Patel Jaymin. Microsponges as the versatile tool for Topical route: A Review, International Journal of Pharmaceutical Science and Research, 2012; 3(9):2926-2937.
8. Jain N, Sharma PK, Banik A. Recent advances on microsponge delivery, International journal of Pharmaceutical Sciences Review and Research, 2011:8(2):13-23.
9. Jain V, Singh R. Development and characterization of EudragitRs 100 loaded microsponges and its colonic delivery using natural polysaccharides. Actapoloniaepharmaceutica-drug research, 2010; 67(4): 407-415.
10. Nanda Shivani. Microsponge drug delivery system: an overview, World Journal of Pharmacy and Pharmaceutical sciences, 2013; 2(3):1032-1043.
11. Khullar R , Kumar D, Seth N, Saini S. Formulation and evaluation of mefenamic acid emulgel for topical delivery. Saudi Pharmaceutical Journal, 2012; 20:63-67
12. D’souza J.I, Masvekar R.R, Pattekari P.P, Pudi S.R, More H.N. Microspongic Delivery of Fluconazole for Topical Application. Indo-Japanese International Conference on Advances in Pharmaceutical Research and Technology, 2004; 76.
13. Pradhan SK. Microsponge as the Versatile Tool for Drug Delivery System International Journal of Pharmaceutical Science and Research, 1(2): 243-258.
14. Chadawar V, Shaji J. Microsponge delivery system. Current Drug Delivery, 2007; 4: 123-129.
15. Aritomi H, Yamasaki Y, Yamada K, Honda H, Koshi M. Development of sustained release formulation of chlorpheniramine maleate using powder coated microsponges prepared by dry impact blending method, Journal of Pharmaceutical Science and Technology, 1996; 56: 49-56.
16. Sharma R, Roderick B, and Pathak K. Evaluation of kinetics and mechanism of drug release from Econazole nitrate microsponges loaded carbopol Hydrogel. Indian Journal of Pharmaceutical Education and research, 2011; 45(1): 25-31.
17. Guyot M and Fawaz F. Microspheres- Preparation and physical characteristics. International Journal of Pharmaceutics, 1998; 175: 61-74.
18. Jones D.S, Pearce K.J. Investigation of the Effects of Some Process Variables on Microencapsulation of Propranolol Hcl by Solvent Evaporation Method. International Journal of Pharmaceutics, 1995; 118: 99-205.
19. Panday Purnima, Shukla Neha, Sisodiya Dharmesh, Jain Vikas, Mahajan Chand Suresh. Design and characterization of microsponge loaded controlled release epicutaneous gel oflornoxicam. Applied Medical Research, 2015; 1(1): 16-21.
20. Saraf Ajay, Dasani Amit, Pathan KH. Microsponge drug delivery system as an innovation in Cosmetic world: A Review. Asian Journal of Pharmaceutical Education and Research, 2012; 1(2): 67-87.
21. Bamane S. Ganesh, Kakade B Tejaswini, Metkari B Vijay, Kulkarni V Laxmikant. Microsponges: A Novel Drug Delivery System. World Journal of Pharmacy and Pharmaceutical Sciences, 2014; 3(3): 748-62.
22. D’souza. J.I. In-vitro antibacterial and skin irritation studies of microsponges of benzyl peroxide. Indian Drugs, 2001; 38: 361-2.
23. Osmani Ali Riyaz, Aloorkar H Nagesh, Kulkarni S Ajit, Harkare R Bhargav, Bhosale R Rohit. A New Cornucopia in Topical Drug Delivery: Microsponge Technology. AsianJournal of Pharmaceutical Science & Technology, 2014; 4(1): 48-60.
24. Kumar Rajnish, Sharma K Sanjay, Jaimini Manish, Alam Nawaz. Microsponge Drug Delivery Systems for Novel Topical Drug Delivery. International Journal of Pharmaceutical Sciences Letters, 2014; 4(3): 384-90.
25. Jyoti, Kumar S. Innovative and Novel Strategy: Microsponges for Topical Drug Delivery System. Journal of Drug Delivery & Therapeutics, 2018; 8(5): 28-34.
26. Hussain Hamid, Juyal Divya, Dhyani Archana. Microsponges: An Overview. International Journal of Drug Delivery Technology, 2014; 4(4): 58-66.
27. Pandey Poornima, Jain Vikas and Mahajan SC. A Review: Microsponge Drug Delivery System. International Journal of Biopharmaceutics, 2013; 4(3): 225-30.
28. Arora Nageen, Agarwal Shilpi, Murthy RSR. Latest Technology Advances in Cosmaceuticals. International Journal of Pharmaceutical Sciences and Drug Research, 2012; 4(3): 168-82.
29. Shah N Chainesh, Shah P Dhiren. Microsponges: A Revolutionary Path Breaking Modified Drug Delivery of Topical Drugs. International Journal of Pharmaceutical Research, 2014; 6(2): 1-13.
30. Bamane S. Ganesh, Kakade B Tejaswini, Metkari B Vijay, Kulkarni V Laxmikant. Microsponges: A Novel Drug Delivery System. World Journal of Pharmacy and Pharmaceutical Sciences, 2014; 3(3): 748-62.
31. Veer SU, Gadhve MV, Khedkar AN. Microsponge: A Drug Delivery System. International Journal of Pharmaceutical and Clinical Research, 2014; 6(4): 385-90.
32. Mandava Sunder Shyam, Thavva Vedavathi. Novel Approach: Microsponge Drug Delivery System. International Journal of Pharmaceutical Science and Research, 2012; 3(4): 967-80.
33. Gupta Akashdeep, Dhyani Archana and Juyal Divya . Microsponges laden gels for topical delivery: A novel approach. The Pharma Innovation Journal 2016; 5(6): 39-43.
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