Novel Strategy: Microsponges for Topical Drug Delivery

  • , Monika
  • Jagdeep Singh Dua
  • D.N. Prasad
  • Mansi Hans
  • Rajni Sharma
  • Satish Kumari

Abstract

Microsponge delivery system is a unique and effective technology for the controlled release of topical agents. It is highly cross- linked porous, polymeric microspheres that can entrap wide range of active agents and in response to trigger or stimuli and release them onto the skin over a time. It consists of micro-porous beads, typically 5-300µm in diameter that acquire the flexibility to entrap a wide variety of active ingredients such as fragrances, sunscreens, emollients, anti-fungal, anti-infective, and anti-inflammatory agents etc., that are mostly used to prolong the topical administration of the drug . Recently it was investigated that microsponges also used for oral drug delivery system. The topical agent formulation with microsponge delivery system can be prepared in many different forms, such as cream, gel, or lotion. When the formulation is applied to the skin, the MDS releases its active ingredients on a time and in response to other stimuli (rubbing, temperature, pH etc.). They reduce side effects, enhance stability and modify drug release. Because of the size of the microsponges they cannot pass through the stratum corneum, so they remain on the skin surface and slowly releasing the active ingredients over a period. Slow rate of release from MDS reduce the irritancy associated with the topical agents. Slow and gradual release pattern of MDS prevents excessive build-up of the active agents in the epidermis and dermis. Therefore, these particles, remains on the surface of the skin and its fine lines delivering the active over prolonged time.                                                                     


Keywords: Microsponge Delivery System, Quasi- emulsion solvent diffusion.

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How to Cite
Monika, , Dua, J. S., Prasad, D., Hans, M., Sharma, R., & Kumari, S. (2019). Novel Strategy: Microsponges for Topical Drug Delivery. Journal of Drug Delivery and Therapeutics, 9(3-s), 1025-1031. https://doi.org/10.22270/jddt.v9i3-s.2935