Isolation and Characterization of Aegle marmelos Gum– A Novel Controlled Release Polymer
Wide ranges of drugs are formulated now in a variety of different forms for oral extended-release dosage forms. However, only those which result in a significant reduction in dose frequency and/or a reduction in toxicity resulting from high concentration in the blood or gastrointestinal tract are likely to improve therapeutic outcomes. To be a successful extended-release product, the drug must be released from the dosage form at a predetermined rate, dissolve in the gastrointestinal fluids, maintain sufficient gastrointestinal residence time, and may be absorbed at a rate and will replace the amount of drug being metabolized and excreted. In a nut shell, controlled-release formulations are a promising way to improve the patient’s compliance by reducing dosing intervals and minimizing adverse effects. Out of many approaches to controlled drug release, matrix based approach is widely used due to its simplicity, scalability and from stability point of view. In order to control the release of drug from its dosage form, an effective controlled release polymer is essential. Though, there are several controlled release polymers available in the market, there is continuous need to develop controlled polymers which are safe and inexpensive. The aim of the work was to isolate and characterize the aegle marmelos gum as novel controlled relase polymer.
Keywords: Isolation, Controlled release, Aegle marmelos Gum.
2. Rohini S. Kharwade, Neha S.Vyavhare, Sachin M.More, Formulation Of Mucoadhesive Tablet By Using Aegle Marmelos Gum, International Journal Of Applied Biology And Pharmaceutical Technology, Jan-Mar -2011, Volume:2, Issue(1).
3. C.K.Kokate, A.P.Purohit. S.B.Gokhale, Pharmacognosy volume–I, June 2010, 45th edition, Pg.No- A.2.
4. C.K.Kokate, A.P.Purohit. S.B.Gokhale, Pharmacognosy volume–I, June 2010, 45th edition, Pg.No-A.1.
5. C.K.Kokate, A.P.Purohit. S.B.Gokhale, Pharmacognosy volume–I, June 2010, 45th edition, Pg.No-7.9.
6. C.K.Kokate, A.P.Purohit. S.B.Gokhale, Pharmacognosy volume–I, June 2010, 45th edition, Pg.No- A.5.
7. Agarwal’s-Text book of Biochemistry, 13th edition, 2005, Pg.No. 85.
8. BP -2008, Volume – IV, Appendix – IX – A 252.
9. G.R.Chatwal, Pharmaceutical Chemistry Inorganic (volume I), 2010, Pg.No-449.
10. C.K.Kokate, A.P.Purohit. S.B.Gokhale, Pharmacognosy volume –I, June 2010, 45th edition, Pg.No-7.9.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).