The Enhancement of solubility and dissolution rate of saxagliptine hydrochloride by solid dispersion technique

  • Krushna Bhiva Ghule VJSM’ Vishal Institute of Pharmaceutical Education and Research, Ale, Tal – Junnar, Dist- Pune(412411) Maharashtra, India
  • Shankar M. Dhobale VJSM’ Vishal Institute of Pharmaceutical Education and Research, Ale, Tal – Junnar, Dist- Pune(412411) Maharashtra, India
  • Vikas D. Kedar VJSM’ Vishal Institute of Pharmaceutical Education and Research, Ale, Tal – Junnar, Dist- Pune(412411) Maharashtra, India
  • Suresh L. Jadhav VJSM’ Vishal Institute of Pharmaceutical Education and Research, Ale, Tal – Junnar, Dist- Pune(412411) Maharashtra, India

Abstract

Saxagliptine hydrochloride, PEG, polaxamer-407,ethyl cellulose were prepared to study the dissolution of sparingly water soluble Saxagliptine hydrochloride drug. solid dispersion of Saxagliptine hydrochloride were prepared using different ratios of PEG 6000 & Polaxamer-407.Some of the practical aspects to be considered for the preparation of solid dispersion such as selection of polymers ,methods of preparation solubility of drug and dissolution study of drug in solid dispersion are also discussed. The present research provides a there is increase in solubility of Saxagliptine hydrochloride and also solid dispersion complex of drug was giving better  dissolution profile as compared to other solid dispersions this imporove bioavailability. FT-IR , shows the compatability of drug & carrier.


Keywords- solid dispersion, solubility enhancement, dissolution rate

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Author Biographies

Krushna Bhiva Ghule, VJSM’ Vishal Institute of Pharmaceutical Education and Research, Ale, Tal – Junnar, Dist- Pune(412411) Maharashtra, India

VJSM’ Vishal Institute of Pharmaceutical Education and Research, Ale, Tal – Junnar, Dist- Pune(412411) Maharashtra, India

Shankar M. Dhobale, VJSM’ Vishal Institute of Pharmaceutical Education and Research, Ale, Tal – Junnar, Dist- Pune(412411) Maharashtra, India

VJSM’ Vishal Institute of Pharmaceutical Education and Research, Ale, Tal – Junnar, Dist- Pune(412411) Maharashtra, India

Vikas D. Kedar, VJSM’ Vishal Institute of Pharmaceutical Education and Research, Ale, Tal – Junnar, Dist- Pune(412411) Maharashtra, India

VJSM’ Vishal Institute of Pharmaceutical Education and Research, Ale, Tal – Junnar, Dist- Pune(412411) Maharashtra, India

Suresh L. Jadhav, VJSM’ Vishal Institute of Pharmaceutical Education and Research, Ale, Tal – Junnar, Dist- Pune(412411) Maharashtra, India

VJSM’ Vishal Institute of Pharmaceutical Education and Research, Ale, Tal – Junnar, Dist- Pune(412411) Maharashtra, India

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How to Cite
Ghule, K., Dhobale, S. M., Kedar, V. D., & Jadhav, S. L. (2019). The Enhancement of solubility and dissolution rate of saxagliptine hydrochloride by solid dispersion technique. Journal of Drug Delivery and Therapeutics, 9(3), 393-396. https://doi.org/10.22270/jddt.v9i3.2903