Microspheres for local drug delivery in bone joints

  • Adarsh Pratik Poudyal Department of Pharmaceutics, Himalayan Pharmacy Institute, Majhitar – 737136, India
  • Chidambaram Soundrapandian Department of Pharmaceutics, Himalayan Pharmacy Institute, Majhitar – 737136, India
DOI https://doi.org/10.22270/jddt.v9i3.2902

Abstract

Bone joints are the junctions between bones in the body which link the skeletal system into a functional whole. A joint may be the connecting point between two or more bones. Overtime, as people age or due to lifestyle or genetic factors, they may experience diseases and pains in the joints. Conventional treatment options for bone and joint diseases, pain and inflammation have a number of drawbacks that obstruct optimal treatment of the disease. Various other treatment methods and formulations have been investigated to remove these drawbacks. Microspheres are one of the most interesting and attractive approaches to eliminate these limitations. In recent years, prolonged release microspheres have been developed and explored as a viable method for delivery of drugs to the bones and joints. Local delivery of drugs to the affected bone or joint offers many advantages over traditional treatment methods including- better therapeutic response, lesser required dose of drug, lesser chances of wastage of drug, better absorption of drug in the diseased site, lesser chances of side effects etc. The objective of this review is to explore the field of drug delivery to bone joints, various methods of development of drug-loaded microspheres, factors that influence the release of drug from the microspheres as well as the types of hurdles faced in their preparation.


Keywords: bone and joint diseases, drug delivery, microspheres, local drug delivery,

Downloads

Download data is not yet available.

Author Biographies

Adarsh Pratik Poudyal, Department of Pharmaceutics, Himalayan Pharmacy Institute, Majhitar – 737136, India

Department of Pharmaceutics, Himalayan Pharmacy Institute, Majhitar – 737136, India

Chidambaram Soundrapandian, Department of Pharmaceutics, Himalayan Pharmacy Institute, Majhitar – 737136, India

Department of Pharmaceutics, Himalayan Pharmacy Institute, Majhitar – 737136, India

Statistics
246 Views | 243 Downloads
How to Cite
1.
Poudyal A, Soundrapandian C. Microspheres for local drug delivery in bone joints. JDDT [Internet]. 15May2019 [cited 19Jan.2021];9(3):719-25. Available from: http://jddtonline.info/index.php/jddt/article/view/2902
Issue
Vol 9 No 3 (2019): Volume 9, Issue 3, May-June 2019
Section
Review
Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).