Evaluation of Immunomodulatory Potential of Amaranthus Dubius Leaf on Rodent Models
Amaranthus dubius is known for its various remedies against many ill conditions. Present study has been carried out to delayed type hypersensitivity reaction also stimulated by Amaranthus dubius significantly indicates that the extract could stimulate the haemopoetic system. The mechanism of action could be unfolded only after detailed investigations whereby the extract modulates the immune system however; the extract contains compounds which had immunomodulatory activity. CMI responses are critical to defence against infectious organisms, infection of foreign grafts, tumor immunity and delayed‐type hypersensitivity reactions. Therefore, increase in DTH reaction in rat in response to T cell dependent antigen revealed the stimulatory effect by pretreatment of levamisole on T cell. DTH is a part of the process of graft rejection, tumour immunity, and, most important, immunity to many intracellular infectious microorganisms, especially those causing chronic diseases.
Keywords: Amaranthus dubius, Immunomodulatory Potential, Antigen, Hypersensitivity
2. Ajagbonna OP, Onifade KI, Suleiman U, Hematological and Biochemical changes in rats given extract of Calotropis procera. Sokoto Journal of Veterinary Sciences 1999; 1:36-42. DOI: 10.1155/2015/253195.
3. Ashok BSK, Lakshman K, Jayaveera KN, Arun AK, Manoj B, Sheshadri SD, Antioxidant and antipyretic properties of methanolic extract of Amaranthus spinosus leaves. Asian Pacific Journal of Tropical Medicine, 2010, 3:702-706. DOI:10.1016/S1995-7645(10)60169-1.
4. Barku VYA, Opoku-Boahen Y, Owusu-Ansah E Mensah EF, Antioxidant activity and the estimation of total phenolic and flavonoid contents of the root extract of Amaranthus spinosus. Asian Journal of Plant Sciences and Research, 2013; 3:69-74. DOI: 10.11648/j.ajbls.20140201.14.
5. Bavarva JH, Narasimhacharya AV, Systematic study to evaluate anti-diabetic potential of Amaranthus spinosus on type-1 and type-2 diabetes. Cell and Molecular Biology, 2013; 59:1818-1825. DOI: 10.1170/215.
6. Choudhury A, Evaluation of physiochemical and phytochemical parameters of Amaranthus spinosus leaves. International Research Journal Pharmacy. 2012, 3:210-211.
7. Girija K, Lakshman K, Udaya C, Sabhya SG, Divya T, Anti-diabetic and anti-cholesterolemic activity of methanol extracts of three species of Amaranthus. Asian Pacific Journal of Tropical Biomedicine, 2011; 1:133-8 DOI: 10.1016/S2221-1691(11) 60011-7.
8. Hilou A, Nacoulmaa OG, Guiguemdeb TR, In vivo antimalarial activities of extracts from Amaranthus spinosus L. and Boerhaavia erecta L. in mice. Journal of Ethnopharmacology, 2006; 103:236-240 DOI: 10.1016/j.jep.2005.08.006.
9. Ilango K, Prakash Yoganandam. G, Arun Kumar K, Kamakshi S, Protective effect of aerial parts of Amaranthus spinosus Linn in Paracetamol induced hepatotoxicity in rats. Archives of Applied Science Research, 2010; 2: 152-158.
10. Jhade D, Ahirwar D, Sharma NK, Hatwar B, Gupta S, Jain VK, Antifertility activities of ethanolic and aqueous root extract of Amaranthus spinosus Linn. in rats. Pharmacology online, 2011; 2:959-967.
11. John OR, Yahaya AA, Emmanuel A, Aqueous Ethanolic Extract of Mangifera indica Stem Bark Effect on the Biochemical and Haematological Parameters of Albino Rats. Archives of Applied Science Research, 2012; 4:1618-1622.
12. Joshua LS, Pal VC, Kumar KLS, Sahu RK, Roy A, Antitumor activity of the ethanol extract of Amaranthus spinosus leaves against EAC bearing swiss albino mice. Der Pharmacia Lettre, 2010; 2:10-15.
13. Kirtikar KR, Basu BD, Indian Medicinal Plants, (2nd Ed), volume I, Oriental Enterprises, New Connaught Place, Dehradun, Uttranchal, India, 2001.
14. Kumar RP, Jindal S, Gupta N, Rana R, An inside review of Amaranthus spinosus Linn: A potential medicinal plant of India. International Journal of Research in Pharmacy and Chemistry, 2014; 4:643-653.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (SeeÂ The Effect of Open Access).