Evaluation of Immunomodulatory Potential of Amaranthus Dubius Leaf on Rodent Models
Abstract
Amaranthus dubius is known for its various remedies against many ill conditions. Present study has been carried out to delayed type hypersensitivity reaction also stimulated by Amaranthus dubius significantly indicates that the extract could stimulate the haemopoetic system. The mechanism of action could be unfolded only after detailed investigations whereby the extract modulates the immune system however; the extract contains compounds which had immunomodulatory activity. CMI responses are critical to defence against infectious organisms, infection of foreign grafts, tumor immunity and delayed‐type hypersensitivity reactions. Therefore, increase in DTH reaction in rat in response to T cell dependent antigen revealed the stimulatory effect by pretreatment of levamisole on T cell. DTH is a part of the process of graft rejection, tumour immunity, and, most important, immunity to many intracellular infectious microorganisms, especially those causing chronic diseases.
Keywords: Amaranthus dubius, Immunomodulatory Potential, Antigen, Hypersensitivity
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