Investigation of anti-inflammatory activity of ethanolic extract of Aconitum Napellus Linn against carrageenan induced paw edema in rats

  • Ruchi Gupta Smriti College of Pharmaceutical Education, Indore, India
  • Rajiv Saxena Smriti College of Pharmaceutical Education, Indore, India
  • Neelesh Malviya Smriti College of Pharmaceutical Education, Indore, India

Abstract

The Indian herbal medicine is evaluated by comprehensive activity of research on herbal plant species and their therapeutic principles in the whole world. In traditional and modern medicine, the medicinal plants are used which have shown their potential in possessing potent bioactive compound. A large number of populations suffer due to various reasons from rheumatoid arthritis of unknown inflammation. The present work is to investigation of anti-inflammatory activity of herbal extracts of Aconitum Napellus Linn against carrageenan induced paw edema in rats. Aconitum Napellus Linn plant extracts used in traditional medicine was investigated for their anti-inflammatory potential against adjuvant carrageenan induced inflammation. Maceration method was used for preparing ethanolic extract. In adjuvant carrageenan induced inflammation, orally administered extracts (100 mg/kg), inhibited the acute as well as chronic inflammation. The ethanolic herbal extract of plant under investigation showed potent anti-inflammatory activity. The anti-inflammatory activity of the extracts was compared to reference drug, diclofenac (10 mg/kg).


Keywords: Anti-inflammatory, Paw edema, Aconitum napelluslinn, Maceration.

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Author Biographies

Ruchi Gupta, Smriti College of Pharmaceutical Education, Indore, India

Smriti College of Pharmaceutical Education, Indore, India

Rajiv Saxena, Smriti College of Pharmaceutical Education, Indore, India

Smriti College of Pharmaceutical Education, Indore, India

Neelesh Malviya, Smriti College of Pharmaceutical Education, Indore, India

Smriti College of Pharmaceutical Education, Indore, India

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How to Cite
Gupta, R., Saxena, R., & Malviya, N. (2019). Investigation of anti-inflammatory activity of ethanolic extract of Aconitum Napellus Linn against carrageenan induced paw edema in rats. Journal of Drug Delivery and Therapeutics, 9(3), 470-472. https://doi.org/10.22270/jddt.v9i3.2892