A Review on Nanohybrids: Technique for Solubility Enhancement of Poorly Water Soluble Drugs
Technique for solubility enhancement of poorly water soluble drugs
In order the drug bioavailable in human body must absorb it, and in oral treatments absorption takes place, after drug dissolution by diffusion of the molecules through gastrointestinal membranes. It was found that BCS class –II drug has poor aqueous solubility in GI tract greatly influences the drug release; particularly it affects the bioavailability of drug. Solubilization of water insoluble drug is a big issue of pharmaceutical research. Nanohybrids are combination of two or more different materials with different properties of each and that are fused, by an effort to blend the best properties of both. In nanohybrids there is use of natural and synthetic polymers. The present review mainly focusing on the simple and convenient method of preparation of nanohybrids with the help of Microwave irradiation Method by using natural/synthetic carriers such as acacia, gelatin, cassia, ghatti gum, and HPMC, MC etc. to enhance the solubility of poorly water soluble BCS Class –II Drugs and improved its rate of dissolution for such drug entities which affects the bioavailability. Prepared nanohybrids can be characterized by Scanning Electron Microscopy, Fourier transform infrared spectroscopy, Differential Scanning Calorimetry, X-Ray Diffraction Studies and transmission Electron Microscopy. Further, this review mainly highlights the application and future prospective use of nanohybrids, which will help in formulation of drug with improved bioavailability.
Keywords: BCS Class II, Nanohybrids, Solubilization, Enhancement of solubility, Optimized drug dissolution and drug release.
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