Preparation and Characterization of Itraconazole Microsponges using Eudragit RSPO and Study the Effect of Stirring on the Formation of Microsponges
The purpose of the present study was to prepare and evaluate Itraconazole loaded microsponges using Eudragit for the controlled release of the drug and study the effect of stirring rate on the formation of microsponges. Microsponges containing Itraconazole were prepared by using quasi-emulsion solvent diffusion method at different stirring rate i.e. 500, 800, 1000, 1200 and 1500rpm. Particle size of prepared microsponge was observed in the range of 78.43 to 23.18 µm. Scanning electron microscopy revealed the porous, spherical nature of the microsponges. The production yield, entrapment efficiency, and drug content were found to be 80.88%, 84.53% and 82.89%. The formulation with higher drug to polymer ratio 1:10 (i.e. F5) was chosen to investigate the effect of stirring rate on the morphology of microsponges. As the speed was increased, the particle size of microsponges was reduced and uniform spherical microsponges were formed. As drug polymer ratio increased, Production yield, drug content and entrapment efficiency was found to be increased while drug: polymer ratio has reverse effect on particle size, as drug: polymer ratio increase, particle size decreases. The cumulative percentage drug release upto 8hrs for F5 was 89.54% and the mechanism of drug release from the formulations during the dissolution was determined using the zero order, first order, higuchi equation and Peppas equation. All formulations were best fitted to Zero order and peppas plot. The best formulation F5 follows Zero order release.
Keywords: Microsponges, Itraconazole, stirring rate, Quasi-emulsion solvent diffusion method
2. Jain V and Singh R. Dicyclomine-loaded eudragit based microsponge with potential for colonic delivery Preparation and characterization, Tropical Journal of Pharmaceutical Research, 2010; 9(1):67-72.
3. Kumari P, Mishra SK. A Comprehensive Review on Novel Microsponges Drug Delivery Approach, Asian Journal of Pharmaceutical and Clinical Research, 2016; 9(1):25-30.
4. Gupta A, Dhyani A and Juyal D. Microsponges laden gels for topical delivery: A novel approach The Pharma Innovation Journal 2016; 5(6):39-43.
5. Kumar JR, Muralidharan S and Parasuraman S. Evaluation of Antifungal Activity of Sustained Release Microsponge Enriched Fluconazole Gel for Penile Candidiasis in Male Rats, International Journal of PharmTech Research, 2014; 6(6):1888-1897.
6. Avhad P S. and Patil PB. A New Era in Topical Formulations – Microsponge Drug Delivery System International Journal of Pharmaceutical Science and Research, 2016; 7(7):2756-2761.
7. Patel A, Upadhyay P, Trivedi JJatin, Shah S and Patel J. Microsponges as the versatile tool for Topical route: A Review, International Journal of Pharmaceutical Science and Research, 2012; 3(9):2926-2937.
8. Jain N, Sharma PK, Banik A. Recent advances on microsponge delivery, International journal of Pharmaceutical Sciences Review and Research, 2011:8(2):13-23.
9. Jain V, Singh R. Development and characterization of EudragitRs 100 loaded microsponges and its colonic delivery using natural polysaccharides. Actapoloniaepharmaceutica-drug research. 2010; 67(4):407-415.
10. Nanda S. Microsponge drug delivery syatem: an overview, World Journal of Pharmacy and Pharmaceutical sciences, 2013; 2(3):1032-1043.
11. Khullar R , Kumar D, Seth N, Saini S. Formulation and evaluation of mefenamic acid emulgel for topical delivery. Saudi Pharmaceutical Journal. 2012; 20:63-67
12. D’souza J.I, Masvekar R.R, Pattekari P.P, Pudi S.R, More H.N. Microspongic Delivery of Fluconazole for Topical Application. Indo-Japanese International Conference on Advances in Pharmaceutical Research and Technology, 2004; 76.
13. Pradhan SK. Microsponge as the Versatile Tool for Drug Delivery System International Journal of Pharmaceutical Science and Research, 1(2): 243-258.
14. Patel N, Tipadia N, Neha Vadgama, Raval M. Formulation and evaluation of microsponge gel for topical delivery of fluconazole for fungal therapy. Journal of Pharmaceutical Investigation 2016; 46(3).
15. Arora N, Agarwal S, Murthy RSR. Latest Technology Advances in Cosmaceuticals. International Journal of Pharmaceutical Sciences and Drug Research, 2012; 4(3):168-82.
16. Shah CN, Shah DP. Microsponges: A Revolutionary Path Breaking Modified Drug Delivery of Topical Drugs. International Journal of Pharmaceutical Research, 2014; 6(2): 1-13.
17. Bamane S. Ganesh, Kakade B Tejaswini, Metkari B Vijay, Kulkarni V Laxmikant. Microsponges: A Novel Drug Delivery System. World Journal of Pharmacy and Pharmaceutical Sciences, 2014; 3(3):748-62.
18. Veer SU, Gadhve MV, Khedkar AN. Microsponge: A Drug Delivery System. International Journal of Pharmaceutical and Clinical Research, 2014; 6(4):385-90.
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