Bilayer Tablet: Novel Technology Use in Extended Release Drug Delivery System
Bilayer tablet is a successful technology of controlled release formulation or extended release formulation to provide successful drug delivery. The name of this development is clear that the tablets have been consisting of two layers, these are immediate release layer (IR) and another is extended release layer (ER). In this era it is very useful in many developing countries as a combination therapy for various disease treatment purposes. Bilayer tablet are needs to separate incompatible active pharmaceutical ingredients (API) by physical separation. In this formulation IR and ER both layers are present and it form extended release layer (ER). This types of formulations helps to maintain plasma level concentration in the body. So, it is a very useful and successful technology in novel drug delivery system.
Keywords: Bilayer tablet, extended drug release, Tablet press,
2. Akram MA, et al. Designing, Development and Formulation of Mouth Disintegrating Telmisartan Tablet with Extended Release Profile Using Response Surface Methodology. J Bioequiv Availab. 2015; 7:262-266.
3. Divya A, et al. A Bilayer Tablet Technology: An overview, Journal of Applied Pharmaceutical Science 2011; 1(8):43-47.
4. Rameshwar V, et al. Bilayer tablets of various drugs : A review, Scholars Academic Journal of Pharmacy, 2014; 3(3): 271-279.
5. Nirmal J, Saisivam S, Peddanna C, et al.; Bilayer tablets of atorvastatin calcium and nicotinic acid: formulation and evaluation. Chem Pharm Bull., 2008; 56(10):1455-1458.
6. Sai Supraja B, Ajay Kumar B, et al.; Formulation and evaluation of bilayer tablets of Sitagliptin Phosphate and Metformin Hydrochloride. Pharmanest An International Journal of Advance Pharmaceutical Sciences. 2013; 4:1114-1120.
7. Sadhana S, Nityanand Z, et al.; Formulation and Evaluation of bilayer tablet Metformin Hydrochloride and Pioglitazone Hydrochloride. International Journal of Pharmacy and Pharmaceutical Sciences. 2012; 4(Suppl 5):380-385.
8. Richa J, Sayantan M, et al.; Combined bilayer floating tablet of Metformin Hydrochloride and Sitagliptin, Research Article. IJPRBS, 2016; Volume 5(1):25-44.
9. Samir JS, Paresh BS, et al.; A review on Extended release drug delivery system and Multiparticulate System. World Journal of Pharmaceutical Research. Volume 4, Issue 8, 724-747.
10. Margret CR, Jaykar B, et al.; Formulation and evaluation of Saxagliptin Immediate release and Metformin Hydrochloride Sustained release tablet. International Journal of Health Sciences, 2013; 1(1):36-47.
11. Schwartz, Joseph; Lieberman, A. Herbert, Lachman, Leon; Pharmaceutical dosage forms – tablets. New York: Dekker. ISBN 0-8287-8044-2.
12. Arvind M, et al.; Review of bilayer tablet and evaluation. Int. J. Drug Res. Tech., 2013; 3(2):21-30.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).