Phytosomes: A Novel Drug Delivery for Herbal Extracts

  • Jayashri J. Bhise Department of Quality Assurance, Channabasweshwar Pharmacy College, Latur, Maharashtra, India
  • Omprakash G. Bhusnure Department of Quality Assurance, Channabasweshwar Pharmacy College, Latur, Maharashtra, India
  • Sneha R. Jagtap Department of Quality Assurance, Channabasweshwar Pharmacy College, Latur, Maharashtra, India
  • Sachin B. Gholve Department of Quality Assurance, Channabasweshwar Pharmacy College, Latur, Maharashtra, India
  • Richa R. Wale Department of Quality Assurance, Channabasweshwar Pharmacy College, Latur, Maharashtra, India

Abstract

The term “phyto” means plant while “some” means cell-like. Phytosome is novel emerging technique applied to phyto-pharmaceutical which contains phytoconstituents to herbal extract surrounds and bound by lipids. Phytosome shows better absorption, hence produces better bioavailability than the conventional herbal extracts. Because of their improved pharmacological and pharmacokinetic properties. Phytosomes are herbal formulation which has enhanced the therapeutic effects of the plant extracts and herbal lead molecule by increasing bioavailability in the target site compared to conventional herbal extracts. This is improved forms of herbal formulation which contain the bioactive phytoconstituents of herb essence enclosed and bound by a lipid. Phytosomes demonstrated improved pharmacokinetic and pharmacodynamic response than customary botanical extracts. 


Keywords: Phytosomes; Bioavailability, Phospolipids, phytoconstituents.   

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Author Biographies

Jayashri J. Bhise, Department of Quality Assurance, Channabasweshwar Pharmacy College, Latur, Maharashtra, India

Department of Quality Assurance, Channabasweshwar Pharmacy College, Latur, Maharashtra, India

Omprakash G. Bhusnure, Department of Quality Assurance, Channabasweshwar Pharmacy College, Latur, Maharashtra, India

Department of Quality Assurance, Channabasweshwar Pharmacy College, Latur, Maharashtra, India

Sneha R. Jagtap, Department of Quality Assurance, Channabasweshwar Pharmacy College, Latur, Maharashtra, India

Department of Quality Assurance, Channabasweshwar Pharmacy College, Latur, Maharashtra, India

Sachin B. Gholve, Department of Quality Assurance, Channabasweshwar Pharmacy College, Latur, Maharashtra, India

Department of Quality Assurance, Channabasweshwar Pharmacy College, Latur, Maharashtra, India

Richa R. Wale, Department of Quality Assurance, Channabasweshwar Pharmacy College, Latur, Maharashtra, India

Department of Quality Assurance, Channabasweshwar Pharmacy College, Latur, Maharashtra, India

References

1. Awasthi R, Kulkarni GT, Pawar VK. Phytosomes: an approach to increase bioavailability of plant extracts. Int J Pharm Pharm Sci. 2011; 3(2): 1-3.
2. Chauhan NS, Gowthamarajan K, Gopalakrishna B. Phytosomes: potential phyto-phospholipid carriers for herbal drug delivery. J Pharm Res. 2009; 2(7): 1267-70.
3. Manach C, Scalbert A, Morand C. Polyphenols: Food Sources and Bioavailability. Am J ClinNutr. 2004; 79:72747.
4. Kidd. P.M., Phosphatidylcholine (Monograph). In: K. Czap, A.L. Miller, K.A. Head, et al, eds. Alternative Medicine Review Monographs Volume One. Dover, ID: Thorne Research, Inc. 2002; 310-315.
5. Kidd P.M., Glutathione (Monograph). In: K. Czap, A.L. Miller, K.A. Head, et al, eds. Alternative Medicine Review Monographs Volume One. Dover, ID: Thorne Research, Inc.. 2002;184-192.
6. Bhattacharya S, Phytosomes: Emerging Strategy in Delivery of Herbal Drugs and Nutraceuticals. Pharma Times 2009; 41(3):8-12.
7. Citernesi U, Sciacchitano M. Phospholipids/active ingredient complexes, Cosm& Toil; 1995;110(11): 57-68.
8. Pawar, H.A. Bhangale, B.D., Phytosome as a Novel Biomedicine: A Microencapsulated Drug Delivery System. J Bioanal Biomed. 2015; 7 (1):06-12.
9. Bombardelli E, Mustich G. Bilobalide?phospholipid comlex, their uses and formulation containing them. 1991.U. S. Patent No. EPO 275005,
10. Citernesi, U. Sciacchitano, M., Phospholipids/active ingredient complexes. Cosm & Toil. 1995;110 (11):57-68.
11. Kidd, P.M., Phosphatidylcholine: a superior protectant against liver damage. Alter Med Rev. 1996; 1 (2):58-74.
12. Priyanka Rathore, Gaurav Swami. Planterosomes: A potential phyto-phospholipid carriers for the bioavailability enhancement of herbal extracts. International Journal of pharmaceutical sciences and research. 2012; 3(3):737-755.
13. Singh RP, Parpani S, Narke R, Chavan R. Phytosome: Recent advance research for novel drug delivery system. Asian Journal of Pharmaceutical Research and Development. 2014; 2(3):15-29.
14. Rani B, Vandana, Nagpal M, Arora S. phytosomes: potential carriers for herbal drugs. Ijrrpas. 2013; 2(3):566-577.
15. Maryana W, Rahma A, Mudhakir D, Rachmawati H. Phytosome containing silymarin for oral administration: Formulation and physical evaluation. J Biomed Sci Eng 2015; 25:56.
16. Singh RP, Gangadharappa VH, Mruthunjaya K. Phytosome loaded novel herbal drug delivery system: A review. Int Res J Pharm 2016; 7(6):15-21.
17. Nagpal N, Arora M, Swami G, Rageeb, Kapoor R. Designing of a phytosome dosage form with Tecomella undulata as a novel drug delivery for better utilization. Pak J Pharm Sci 2016; 29(4):1231-5.
18. Comoglio A., Tomasi A., Malandrino S., et al. Scavenging effect of silipide?A new silybinphospholipid complex, on ethanolderived free radicals. Biochem. Pharmacol., 1995;50: 1313-1316.
19. Delgi U., Urbino S. D. Tolerability and cutaneous sensitization study in healthy volunteers after topical application of the product glycyrrhetinic acid? Phytosome® ointment. Unpublished data submitted by CTFA, 2004; 36:2.
20. Pandey S, Patel K. Phytosomes: Technical revolution in phytomedicine. Int J Pharma Tech Res 2010; 2:627-31.
21. Jain N et. al. Phytosome: A Novel Drug Delivery System for Herbal Medicine. International Journal of Pharmaceutical Sciences and Drug Research 2010; 2(4): 224-228.
22. Battacharya S. Phytosomes: Emerging strategy in delivery of herbal drugs and nutrceuticals. Pharm Times 2009; 41:3.
23. Chauhan NS, Gowtham R, Gopalkrishna B. Phytosomes: A potential Phyto?phospholipid carriers for herbal drug delivery. J Pharm Res 2009; 2:1267-70.
24. Bhattachrya S. Phytosomes: The new technology for enhancement of bioavailability of botanicals and nutraceuticals. Int J Health Res 2009; 2:225.
25.Hikino H, Kiso Y, Wagner H, Fiebig M. Antihepatotoxic actions of flavonolignans from Silybum marinum fruits. Planta Med 1984; 50:248-50.
26. Valenzula A, Aspillaga M, Vial S, Guerra R. Selectivity of Silymarin on the increase of the glutathione content on different tissues of the rat. Planta Med 1989; 55:420-2.
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How to Cite
Bhise, J. J., Bhusnure, O. G., Jagtap, S. R., Gholve, S. B., & Wale, R. R. (2019). Phytosomes: A Novel Drug Delivery for Herbal Extracts. Journal of Drug Delivery and Therapeutics, 9(3-s), 924-930. https://doi.org/10.22270/jddt.v9i3-s.2863