To study the comparative dissolution profiles of sustained release tablets of metformin hydrochloride by using various hydrophilic polymers
In this research study an attempt was made to formulate sustained release matrix tablets of Metformin Hydrochloride as it possesses relatively shorter plasma half-life, low bioavailability. The sustained release formulations of the drug were capable of maintaining the plasma level for 8-12 hours. The overall objective of this research was to formulate the tablet by using various hydrophilic polymers i.e. Xanthan gum, Guar gum, Aloe barbadensis and Methocel K4M. Tablets were prepared by wet granulation method. In Vitro studies were performed by USP XX apparatus I, basket and the data was analyzed using zero order, first order, and Korsmeyer and Higuchi models. Nine formulations were made, out of which F-9 formulation which was composed of Aloe Barbadensis in the ratio of 1:2, with combination of other polymers (xanthan gum, guar gum and methocel K4 M) showed maximum drug release within 12 hours with sustained release profile because Aloe barbadensis showed maximum swelling followed by entanglement of polymers chains, thus gave maximum gel strength which provides main retarding factor for the drug release. The use of three polymers (xanthan gum, guar gum and methocel K4M) alone in the different formulations i.e. from F-1 to F-6 was not able to sustain the drug release because of their rapid solubilization in acidic pH leads to pores in the matrix, finally causes surface erosion and initial disaggregation of the matrix tablet prior to gel layer formation around tablet core causes rapid release of the drug within 1 hour as compared to F-9 formulation.
Keywords: Sustained drug delivery system, Aloe Vera, Methocel K4M, Xanthan gum, Guar gum and Metformin HCl.
2. Shanmugam S, Babu R, Satheeshkumar S, Shanmugasundaram P, Formulation and evaluation of sustained release matrix tablets of levosulpiride using natural polymers, Asian Journal of Pharmaceutical and Clinical Research, 2017; Volume 10 Issue 5:286-292.
3. Kaushal M, Monali M, Mishra D, Mittal P, Sorathiya U, Shelat P, Oral controlled release drug delivery system: An overview, International Research Journal of Pharmacy, 2013; 4(3):70-76.
4. Jethara S, Patel M and Patel A, Sustained release drug delivery systems: A patent overview, Aperito Journal of Drug Designing and Pharmacology, 2014; 1:104:2-14.
5. Ratnaparkhi MP, Gupta P, Sustained release oral drug delivery system: An overview, International Journal of Pharma Research and Review, 2013; 2(3):11-21.
6. Pawan P, Mayur P, Ashwin S, Role of natural polymers in sustained release drug delivery system: Applications and recent approaches, International Research Journal of Pharmacy, 2011; 2(9):6-11.
7. Wadher KJ, Kakde RB, Umekar MJ, Formulation and evaluation of a sustained release tablets of metformin hydrochloride using hydrophilic synthetic and hydrophobic natural polymers, Indian Journal of Pharmaceutical Sciences, 2011:2018-215.
8. Sharma A, Bhatt V, Sustained release matrix type drug delivery system: A review, World Journal of Pharmacy and Pharmaceutical Sciences, 2015:1002-1022.
9. Hindustan Abdul Ahad, Sreeramulu J, Bindu Hima V, Reddy Y, Formulation and evaluation of Aloe barbadensis miller mucilage based controlled release matrix tablets of glimepiride, Asian Journal of Chemistry, 2009; Volume 21 No.8:6271-6276.
10. Adimulka S, Devandha A, Formulation and evaluation of sustained release tablets of metformin hydrochloride, World Journal of pharmaceutical Sciences, 2017; Volume 6 Issue 17:632-648.
11. Patel KB, Vyas JR, Upadhyay, Formulation and evaluation of sustained release matrix tablets of Nateglinide, Journal of Drug Delivery and Therapeutics, 2015; 5(5):19-15.
12. Lachman L, Lieberman HA, Kanig JL. The theory and practice of industrial pharmacy. 3rd ed. Mumbai: Varghese Publishing House; 1987. P. 300-304.
13. Satyanarayana T, Rajitha V, Kumar S, Shaji G, Saranya P, Formulation and evaluation of metformin hydrochloride extended release tablets, Pelagia Research Library, 2012; 3(1):58-63.
14. Dahima R, Formulation and evaluation of sustained release granules of Nitazoxanide, Journal of Chemical and Pharmaceutical Research, 2018; 10(2):20-24.
15. Nikunj B, Modi D, Bhardia PD, Formulation, development and evaluation of sustained release matrix tablets of repaglinide, 2014;3(2):370-396.
16. Jain S, Yadav SK, Patil UK, Preparation and evaluation of sustained release matrix tablet of furosemide using natural polymers, Research Journal Pharmaceutical and Technology, 2008; 1(4):374-376.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (SeeÂ The Effect of Open Access).