Emerging Novel Drug Delivery System for Control Release of Curcumin through Sodium Alginate/Poly(ethylene glycol) Semi IPN Microbeads-Intercalated with Kaolin Nanoclay
The aim of the present work is fabrication of Curcumin encapsulated microbeads from Sodium Alginate/Polyethylene Glycol/Kaolin using glutaraldehyde as crosslinker by simple ionotropic gelation technique. The developed microbeads were characterized by Fourier transform infrared spectroscopy to confirm the formation of microbeads. Differential scanning calorimetry and X-ray diffraction studies have confirmed uniform molecular dispersion of CUR in the microbeads. Encapsulation efficiency of CUR in microbeads was ranged from 40 to 49%. Dynamic swelling studies and in vitro release kinetics were performed in simulated intestinal fluid (pH 7.4) and simulated gastric fluid (pH 1.2) at 37 oC. The results suggest that both swelling studies and cumulative release studies were depend on pH of the test medium, which might be suitable for intestinal drug delivery. The in vitro release data were analysed by using Korsmeyer peppas equation to compute the diffusion exponent (n); the results suggest that it followed non-Fickian diffusion.
Keywords: Sodium Alginate, Polyethylene Glycol, Kaolin, Microbeads, Drug delivery
2. Massaro M, Colletti CG, Lazzara G, SRiela S, The Use of Some Clay Minerals as Natural Resources for Drug Carrier Applications, Journal of Functional Biomaterials, 2018, 9:58-79.
3. Isabel Carretero M, Manuel Pozo, Clay and non-clay minerals in the pharmaceutical industry Part I. Excipients and medical applications, Applied Clay Science, 2009; 46:73-80.
4. López-Galindo A, Viseras C, Aguzzi C, Cerezo P, Pharmaceutical and Cosmetic Uses of Fibrous Clays, Developments in Clay Science, 2011, 3:299-324.
5. Carretero M.I., Gomes C.S.F., Tateo F., Clays, Drugs, and Human Health. Developments in Clay Science, 2013; 5:711-764.
6. Chávez-Delgado M.E., Kishi-Sutto C.V., La-Riva X.N.A.D., Rosales-Cortes M., Gamboa-Sánchez P., Topic usage of kaolin-impregnated gauze as a hemostatic in tonsillectomy, Journal of Surgical Research, 2014; 192:678-685.
7. Hu P.W., Yang H.M., Insight into the physicochemical aspects of kaolins with different morphologies, Applied Clay Science, 2013; 74:58-65.
8. Liang Y, Xu C, G. Li, T. Liu, J.F. Liang, X. Wang, Graphene-kaolin composite sponge for rapid and riskless hemostasis, Colloids and Surfaces B: Biointerfaces, 2018; 169:168-175.
9. Sena M.J., Douglas G., Gerlach T., Grayson J.K., Pichakron K.O., D. Zierold, A pilot study of the use of kaolin-impregnated gauze (Combat Gauze) for packing high-grade hepatic injuries in a hypothermic coagulopathic swine model, Journal of Surgical Research, 2013; 183:704-709.
10. Myung Hun Kim, Goeun Choi, Ahmed Elzatahry, Ajayan Vinu, Young Bin Choy, Jin-Ho Choy, Review of clay-drug hybrid materials for biomedical applications: administration routes, Clays and Clay Minerals, 2016; 64(2):115-130.
11. Zhu L., Zhang L., Tang Y., D. Ma, J. Yang, Synthesis of kaolin/sodium alginate-grafted poly(acrylic acid-co-2-acrylamido-2-methyl-1-propane sulfonic acid) hydrogel composite and its sorption of lead, cadmium, and zinc ions, Journal of Elastomers & Plastics, 2015; 47(6):488-501.
12. Sanchez-Ballester N.M., Soulairol I., Bataille B., Sharkawi T., Flexible heteroionic calcium-magnesium alginate beads for controlled drug release, Carbohydrate Polymers, 2019; 207:224-229.
13. Borges O., Cordeiro-da-Silva A. , Romeijn S.G. , Amidi M., de Sousa A., Borchard G, Junginger H.E., Uptake studies in rat Peyer's patches, cytotoxicity and release studies of alginate coated chitosan nanoparticles for mucosal vaccination, Journal of Controlled Release, 2006; 114(3):348-358.
14. Lee K.Y., Mooney D.J., Alginate: properties and biomedical applications, Progress in Polymer Science, 2012; 37(1):106-126.
15. Subhraseema Das and Usharani Subuddhi, Controlled Delivery of Ibuprofen from Poly(vinyl alcohol)−Poly(ethylene glycol) Interpenetrating Polymeric Network Hydrogels, Journal of Pharmaceutical Analysis, 2019; 9(2):108-116.
16. Anisha A. D’souza & Ranjita Shegokar, Polyethylene glycol (PEG): a versatile polymer for pharmaceutical applications, Expert Opinion on Drug Delivery, 2016 13(9):1257-75.
17. Bing-Liang Ma, Yan Yang, Yan Dai, Qiao Li, Ge Lin, Yue-Ming Ma, Polyethylene glycol 400 (PEG400) affects the systemic exposure of oral drugs based on multiple mechanisms: taking berberine as an example, RSC Advances, 2017; 7:2435-2442.
18. Bendels S., Tsinman O., Wagner B., D. Lipp, I. Parrilla, M. Kansy, A. Avdeef, PAMPA-Excipient Classification Gradient Map, Pharmaceutical Research, 2006; 23(11):2525-2535.
19. Parlato M., Reichert S., N. Barney, et al., Poly(ethylene glycol) hydrogels with adaptable mechanical and degradation properties for use in biomedical applications, Macromolecular Bioscience, 2014; 14:687-698.
20. Lin C.C., K. S. Anseth, PEG hydrogels for the controlled release of biomolecules in regenerative medicine, Pharmaceutical Research, 2009; 26:631-643.
21. Wang Q., N. Zhang, X. Hu, et al., Alginate/polyethylene glycol blend fibers and their properties for drug controlled release, Journal of Biomedical Materials Research Part A, 2007; 82:122-128.
22. Bisht S., and Maitra A., Systemic Delivery of Curcumin: 21st Century Solutions for an Ancient Conundrum, Current Drug Discovery Technologies, 2009; 6:192-199.
23. Srimal R. C., Dhawan B. N., Pharmacology of diferuloyl methane (curcumin), a non-steroidal anti-inflammatory agent, Journal of Pharmacy and Pharmacology, 1973; 25:447-452.
24. Ruby A.J., G.Kuttan, K.Dinesh Babu, K.N.Rajasekharan, R.Kutta, Anti-tumour and antioxidant activity of natural curcuminoids, Cancer Letters, 1995; 94(1):79-83.
25. Kim M.K., Choi G.J., H.S. Lee, Fungicidal property of Curcuma longa L. rhizome-derived curcumin against phytopathogenic fungi in a greenhouse, Journal of Agricultural and Food Chemistry, 2003; 51(6):1578-1581.
26. Deodhar S.D., Sethi R., Srimal R.C., Preliminary study on antirheumatic activity of curcumin (diferuloyl methane), Indian Journal of Medical Research, 1980; 71:632-634.
27. Srivastava R., M. Dikshit, R.C. Srimal & B.N. Dhawan, Anti-thrombotic effect of curcumin, Thrombosis Research, 1985; 40:413-417.
28. Aggarwal B.B., S. Banerjee, U. Bharadwaj, B. Sung, S. Shishodia, G. Sethi, Curcumin induces the degradation of cyclin E expression through ubiquitin-dependent pathway and up-regulates cyclin-dependent kinase inhibitors p21 and p27 in multiple human tumor cell lines, Biochemical Pharmacology, 2007; 73:1024-1032.
29. Chen H.W., Huang H.C., Effect of curcumin on cell cycle progression and apoptosis in vascular smooth muscle cells. British Journal of Pharmacology, 1998; 124:1029-1040.
30. Rekik S.B., Gassara S., Bouaziz J., A. Deratani, S. Baklouti, Development and characterization of porous membranes based onkaolin/chitosan composite, Applied Clay Science, 2017; 143:1-9.
31. Shameli K, Ahmad M.B., Jazayeri S.D., Sedaghat S, Shabanzadeh P, H. Jahangirian, M. Mahdavi, Y. Abdollahi, Synthesis and Characterization of Polyethylene Glycol Mediated Silver Nanoparticles by the Green Method, International Journal of Molecular Sciences, 2012; 13:6639-6650.
32. Madhusudana Rao K, Krishna Rao K.S.V., Ramanjaneyulu G., Chang-Sik Ha, Curcumin encapsulated pH sensitive gelatin based interpenetrating polymeric network nanogels for anti cancer drug delivery, International Journal of Pharmaceutics, 2015; 478:788-795.
33. Zhang Y, Long M, Huang P, Yang H, Chang S, Hu Y, Tang A, Mao L. Intercalated 2D nanoclay for emerging drug delivery in cancer therapy. Nano Research, 2017; 10:2633-2643.
34. Eswaramma S, K.S.V. Krishna Rao, Synthesis of dual responsive carbohydrate polymer based IPNmicrobeads for controlled release of anti-HIV drug, Carbohydrate Polymers, 2017; 156:125-134.
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