Effervescent Floating Drug Delivery System: A review

  • Nilesh V Pakhale Department of Pharmaceutics, R.G. Sapkal College of Pharmacy, Anjaneri-4222213, Dist.-Nashik, Maharashtra, India
  • S.B Gondkar Department of Pharmaceutics, R.G. Sapkal College of Pharmacy, Anjaneri-4222213, Dist.-Nashik, Maharashtra, India
  • R.B. Saudagar Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjaneri-4222213, Dist.-Nashik, Maharashtra, India

Abstract

Effervescent floating drug delivery systems release gas CO2, thus reduce the density of the system and remain buoyant in the stomach 2 for a prolonged period of time and released the drug slowly at a desired rate so it can be used to prolong the gastric residence time in order to improve the bioavailability of drug. In the present article we will discuss in detail about effervescent agent and mechanism of effervescent floating drug delivery system. Oral sustained release gastro-retentive dosage forms offer many advantages for drugs with the absorption from upper parts of the gastro intestinal tract. Gastric emptying is a complex process and it is highly variable. The floating drug delivery systems are useful methods to avoid this variability which increases the retention time of the drug delivery systems for more than 12 hours.  This review article is in pursuit of giving detailed information on the pharmaceutical basis of their design, classification, advantages, in vitro and in vivo evaluation parameters, and application of floating systems, and applications of these systems. These systems are useful to several problems encountered during the development of a pharmaceutical dosage form and the future potential of FDDS. At attempt has been made in this review article to introduce the readers to current development in floating drug delivery system,


Keywords: Effervescent system, Floating drug delivery system, Effervescent agent, floating lag time, Gastric residence time.

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Author Biographies

Nilesh V Pakhale, Department of Pharmaceutics, R.G. Sapkal College of Pharmacy, Anjaneri-4222213, Dist.-Nashik, Maharashtra, India

Department of Pharmaceutics, R.G. Sapkal College of Pharmacy, Anjaneri-4222213, Dist.-Nashik, Maharashtra, India

S.B Gondkar, Department of Pharmaceutics, R.G. Sapkal College of Pharmacy, Anjaneri-4222213, Dist.-Nashik, Maharashtra, India

Department of Pharmaceutics, R.G. Sapkal College of Pharmacy, Anjaneri-4222213, Dist.-Nashik, Maharashtra, India

R.B. Saudagar, Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjaneri-4222213, Dist.-Nashik, Maharashtra, India

Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjaneri-4222213, Dist.-Nashik, Maharashtra, India

References

1. Khairnar Vinit S, Patil S.T, Pawar S.P,Effervescent Floating drug delivery system:a review,International Journal of Pharma and Chemical research,vol3,April-Jun 2017; 260-266
2. Rathod H, Patel V, modasia M, floating drug delivery system,innovative approch of gastroretention international journal of pharmaceutical science review and research,volume4,sept-oct 2010; 183-192
3. Hardenia SS, jain A, Patel R, floating drug delivery system: a review,asian journal of pharmacy and life science,volume1,july-sept 2011; 282-293
4. Ahmed A, Goyal NR, Sharma PK, effervescent floating drug delivery systeM, Global journal of pharmacology 2014; 8(4):478-485
5. Pande SD, Vaidya PV, Gulhane PN, Floating drug delivery system; a new way for oral drug delivery system,international journal of pharmaceutical and clinical science 2013; 3(1):1-13
6. Nayak BS, Suna PK, Patel PR, floating drug delivey system:current research,internatinal of pharmaceutical science, 2014; 4(2):14-24
7. Choudhary K.P.R., Ravi Shankar K., Teeda V, floating drug delivery system;a review of recent research,journal of pharmaceutical and applied science 2014; 4(2):14-24
8. Jain A, Hatila K, Umashankar, floating drug delivery system:a review,international journal of pharmaceutical studies and research,July-sept 2011; 1-06
9. Gupta P, Kothiyal P, floating drug delivery system:a review,international journal of pharma research and review,august 2015; 4(8):37-44
10. Ghosh DR,. Haque MA, Rahman MM, Banu MR, floating drug delivery system:a review,journal of drug discovery and therapeutics 2013; 1(8):52-59
11. Kataria S, Middha A, Bhardwaj S, floating drug delivery system:a review ,international research journal of pharmacy,2011; 2(9):18-24
12. Arunachalam A, Karthikeyan M, Konam K, Manidipa S, floating drug delivery system:a review,international journal of research pharmaceutical science, 2011; 2(1):76-83
13. Tripathi P, Khar RK, Vishwavibhuti, floating drug delivery system;a review,international journal of research and development in pharmacy and life science, 2012; 1-10
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How to Cite
Pakhale, N. V., Gondkar, S., & Saudagar, R. (2019). Effervescent Floating Drug Delivery System: A review. Journal of Drug Delivery and Therapeutics, 9(3-s), 836-838. https://doi.org/10.22270/jddt.v9i3-s.2817