Liquid Filled Hard Gelatin Capsule
Novel dosage forms emerges more and more in recent years. One of them is liquid-filled hard gelatin capsules, which have gelatin or the hydroxypropyl methyl cellulose (HPMC) as capsule shell. The liquid-filled hard gelatin capsule is gradually getting attention because of its new-concept dosage form design, which bring liquid drugs by solid form. The paper mostly presents application, pharmaceutical manufacturing, quality assessment, vision of liquid-filled hard gelatin capsules and emphases on the application and pharmaceutical manufacturing of liquid-filled capsule. It is recommended that the capsule is suitable for many liquid or semi-solid natural plant extract and achieve different release profiles. The preparation adopted liquid-filled hard capsules technology. The impact factors concluded property of shell and device of filling. The quality was frequently evaluated by moisture content of capsule shell, dissolution rate. At the same time, it was pointed out that the new dosage form has remarkable marketing prospect and bring profits for enterprises.
Keywords: Liquid filled capsule, Capsule Shell, Gelatin, HPMC, Dissolution rate.
2. Ghirardi P, Catenazzo G, Mantero O, Merotti GC and Marzo C. J. Pharm. Sci; 1977; 66(2):267-269.
3. Walker SE, K. Bedford, and T. Eaves, British patent; 1980; 30:572-226.
4. Duerr M, Fridolin HU and Gneuss KD, Acta Pharm. Technology; 1983; 29 (3):245-251.
5. Kovarik JM, Mueller EA, Van JB, Tetzloff W and Kutz K, J. Pharm. Sci.; 1994; 83:444-446.
6. Patent, Oil-Free Pharmaceutical compositions containing cyclosporin A, WO 93/20833, 1993.
7. Hawley AR, Rowley G, Lough WJ, Chatham SM, Drug Devel. Ind. Pharm.; 1992; 18 (16):1719.
8. Cade and Madit, Capsugel Library, BAS 191.
9. Vijaykumar N, Anusha Reddy R, Journal of Pharmacy; 2013; 1(1): 10-18.
10. Greenwood SC. Sven S, Capsugel B. Hard gelatin capsules today and tomorrow. Capsugel Library Greenwood, USA; 2002: 3-23.
11. Liquid Encapsulation Microspray Sealing (LEMS), Capsugel, Greenwood, SC. Wittwer F, Pharm. Manuf.;1985; 2:24-27.
12. Richardson M and Stegemann S. The filling of two-piece hard gelatin capsule with liquid; Jan 2007.
13. Reddy B, Deepthi A, Ujwala P. Capsule production- Industrial view. Journal of global trends in pharmaceutical sciences; 2012; 3(4):887-909.
14. Balivada R. Solubilized formulation and evaluation of Liquid filled hard gelatin capsules of Estrogen receptor modulator drug. International journal of research in pharmacy and chemistry; 2011; 1(4):1046-1057.
15. Tripura Sundari V, Swetha G. Formulation and evaluation of SMEDDS containing febuxostat by employing coconut oil and labrasol as oil and surfactant system. International Journal of Research in Pharmacy and Pharmaceutical Sciences March 2018; 3(2):48-53.
16. Deva Prasad V. Formulation and modifying drug release from Hard and Soft Gelatin Capsules for Oral drug delivery. International Journal of Research and Development in Pharmacy & Life Science; June-July 2017; 6(4):2663-2677.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (SeeÂ The Effect of Open Access).