Memory enhancing activity of hydroalcoholic extract of Brassica oleracea on scopolamine induced amnesic rats

  • Aashruti Agrawal Department of Pharmacy Practice, PES College of Pharmacy, Bengaluru, Karnataka, India-560 050
  • Ankur Joshi Modern Institute of Pharmaceutical Sciences, Indore, M.P., India
  • Sapna Malviya Modern Institute of Pharmaceutical Sciences, Indore, M.P., India
  • Anil Kharia Modern Institute of Pharmaceutical Sciences, Indore, M.P., India

Abstract

Memory is the retention power of information in the brain. of Brassica oleracea commonly called ‘Broccoli’ has been known for its anti-inflammatory action. In this investigation, memory enhancing activity of Brassica oleracea is to be undertakenTwo doses of the drug Brassica oleracea extract (100 mg/kg and 200 mg/kg p.o) were selected after acute toxicity studies were subjected for the evaluation of cognition and memory enhancing paradigm against scopolamine (0.4mg/kg, i.p) induced amnesic albino rats. Piracetam (120 mg/kg i.p) served as standard drug for both the models (Elevated T maze, Passive avoidance test) undergoing investigation. Brain Anticholinesterase activity was observed as biochemical parameter for estimation. Both dose (100 mg/kg & 200mg/kg) of Brassica oleracea extract has shown dose dependent notable decrement in Transfer latency (TL) by EPM, reduced Anti Cholinesterase activity in brain signifies improved learning when compared to the test scopolamine group. Sub-acute long term treatment was found to be more significant than acute i.e. short term treatment on cognition and memory enhancing activity.


Keywords- Brassica oleracea, Cognition, Scopolamine Anti Cholinesterase, Amnesia

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Author Biographies

Aashruti Agrawal, Department of Pharmacy Practice, PES College of Pharmacy, Bengaluru, Karnataka, India-560 050

Modern Institute of Pharmaceutical Sciences, Indore, M.P., India

Ankur Joshi, Modern Institute of Pharmaceutical Sciences, Indore, M.P., India

Modern Institute of Pharmaceutical Sciences, Indore, M.P., India

Sapna Malviya, Modern Institute of Pharmaceutical Sciences, Indore, M.P., India

Modern Institute of Pharmaceutical Sciences, Indore, M.P., India

Anil Kharia, Modern Institute of Pharmaceutical Sciences, Indore, M.P., India

Modern Institute of Pharmaceutical Sciences, Indore, M.P., India

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How to Cite
Agrawal, A., Joshi, A., Malviya, S., & Kharia, A. (2019). Memory enhancing activity of hydroalcoholic extract of Brassica oleracea on scopolamine induced amnesic rats. Journal of Drug Delivery and Therapeutics, 9(2-A), 81-84. Retrieved from http://jddtonline.info/index.php/jddt/article/view/2786