Formulation and Evaluation of Fast Dissolving Oral Films of an Anti-Migrain Drug (Zolmitriptan)
AbstractZolmitriptan known for its anti-migrain activity. The fast dissolving oral film of drug Zolmitriptan was designed in order to relief and ease the pain caused to patient suffering from Migraine followed by nausea, vomiting and sensitivity towards light/sound. The oral film was prepared using HPMC (Hydroxy Propyl Methyl Cellulose) as polymer and PEG as plasticizer by solvent casting method. The aim of preparing fast dissolving oral film of drug zolmitriptan was to have better Bioavability, quick onset of action (quick relief) and to prevent first pass metabolism. Films were subjected to physicochemical characterization such as thickness, weight variation, folding endurance drug content and were found to be satisfactory. The surface pH of all the films was found to be neutral. The results of the studies indicated that HPMC E50 could be used as a film forming polymer for the formulation. All the films prepared using HPMC E50 showed acceptable mechanical properties. On the basis of tensile strength, drug content and in vitro dissolution, formulation F3 was found to be the promising formulation showing better strength and good drug release profile. Also this formulation was stable for a period of 45 days with no significant change in drug content and drug release profile. Thus it could be said that the fast dissolving sublingual film of Zolmitriptan could be a better option for acute treatment of migraine attacks compared to the available conventional dosage forms.
Keywords: Zolmitriptan, Fast dissolving, HPMC
Download data is not yet available.
271 Views | 210 Downloads
How to Cite
Rathore N, Nizami T, Mangal A, Malviya N, Chauhan V, Salvi N. Formulation and Evaluation of Fast Dissolving Oral Films of an Anti-Migrain Drug (Zolmitriptan). JDDT [Internet]. 24Apr.2019 [cited 20Oct.2020];9(2-A):59-1. Available from: http://jddtonline.info/index.php/jddt/article/view/2780
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).