Nanoparticle in Pharmaceutical Drug Delivery System: A Review

  • Shivani Saokar Department of Pharmaceutical Quality Assurance, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, India.
  • Ravindranath Saudagar Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, India.

Abstract

The most emerging branch in pharmaceutical sciences is “nanotechnology.” Nanopharmaceuticals comprised of nano- sized products which can be transformed in numerous ways to improve their characteristics. Nanoparticles reveal enormous potential in tissue engineering, carriers in drug delivery, understanding of basic biological processes, imaging, sensing, disease diagnostics and therapeutics. Application of nontechnology in drug delivery and medicine has paved new pathways and opened many doors for providing customizable and safer treatment option. There are significant advantages of nanoparticles which make them more potential and effective than the conventional drug delivery system in terms of high stability, high specificity, high drug carrying capacity,ability for targeted release, controlled delivery, possibility to use in different route of administration and the capability to deliver both hydrophilic and hydrophobic drug molecules, site specific targeting. Nanomaterials like polymeric nanoparticles, magnetic nanoparticles, liposomes, carbon nanotubes, quantum dots, dendrimers, metallic nanoparticles, polymeric nanoparticles, etc. have brought about revolutionary changes in drug delivery systems and in many other fields. So that, through the manipulation of molecular size and surface properties, researchers are able to deliver drugs for longer period of time with less frequent dosing and with greater precision and penetration in difficult to access tissues.The present chapter summarizes the types of nanopharmaceuticals with the properties, characterization and methods of preparation, advantages, and applications of nanoparticles in pharmaceutical and medical sector.


Keywords: Nanotechnology, Nanoparticles, Preparation, Characterization, Applications.

Downloads

Download data is not yet available.

Author Biographies

Shivani Saokar, Department of Pharmaceutical Quality Assurance, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, India.

Department of Pharmaceutical Quality Assurance, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, India.

Ravindranath Saudagar, Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, India.

Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, India.

References

1] Edina C, Wang and Andrew Z. Wang, Nanoparticles and their applications in cell and molecular biology. Integrative biology, 2014; 6(1):9-26.
2] Tasana P, Nanotechnology: Effective topical delivery systems, Asian journal of pharmaceutical sciences, 2016; (11):16–17.
3] Khan, I. et al., Nanoparticles: Properties, applications and toxicities. Arabian Journal of Chemistry (2017), http://dx.doi.org/ 10.1016/j.arabjc.2017.05.011
4] Verma S and Makkar D, Solid lipid nanoparticles: a comprehensive review, Journal of Chemical and Pharmaceutical Research, 2016; 8(8):102-114.
5] Vishal J. Lingayat*, Nilesh S. Zarekar, Rajan S. Shendge, Solid Lipid Nanoparticles: A Review,Nanoscience and Nanotechnology Research, 2017; (2): 67-72.
6] Vijay Mishra, Kuldeep K. Bansal, AsitVerma, NishikaYadav, Sourav Thakur, Kalvatala Sudhakar and Jessica M. Rosenholm. Solid Lipid Nanoparticles: Emerging Colloidal Nano Drug Delivery Systems Pharmaceutics 2018; 10(191); doi:10.3390/pharmaceutics10040191
7]Shun-rongJi, Chen Liu, Bo Zhang, Feng Yang, Jin Xu, Jiang Long, Chen Jin, De-liang Fu, Quan-xing Ni, Xian-jun Yu, Carbon nanotubes in cancer diagnosis and therapy, BiochimicaetBiophysicaActa 2010; 1806:29–35.
8] Bhatia S, Nanopaticles types, classification, characterization, fabrication method and drug delivery applications, Natural polymer drug delivery systems, Springer International Publishing Switzerland 2016; DOI 10.1007/978-3-319-41129-3_2
9] Croy SR, Kwon GS, Polymeric Micelles for Drug Delivery,Current Pharmaceutical Design, 2006; (12):4669-4684.
10]Vicky V. Mody, Rodney Siwale, Ajay Singh, Hardik R. Mody, Introduction to metallic nanoparticles, Journal of Pharmacy and Bioallied Sciences October-December 2010; 2(4):282-289.
11] Reshma VG, Mohanan PV, Quantum dots: Applications and safety consequences, Journal of Luminescence,https://doi.org/10.1016/j.jlumin.2018.09.015
12] Christoph Bantz, Olga Koshkina and Michael Maskos, The surface propeeties of nanoparticles determine the agglomeration state and the size of the particles under physiological conditions,Beilstein journal of nanotechnology, 2014; (5):1774-1786.
13] Syed A.A. Rizvi, Ayman M. Saleh, Applications of nanoparticlesystems in drug delivery technology, Saudi Pharmaceutical Journal, 2018; (26):64–70.
14] Rajput N, Methods of preparation of nanoparticles – A review, International Journal of Advances in Engineering & Technology, 2015; 7 (4):1806-1811.
15] Néstor Mendoza-Muñoz, Sergio Alcalá-Alcala and David Quintanar-Guerrero, Preparation of Polymer Nanoparticles by the Emulsification-Solvent Evaporation Method: From Vanderhoff’s Pioneer Approach to Recent Adaptations,Springer International Publishing Switzerland 2016 C. Vauthier and G. Ponchel (eds.), Polymer Nanoparticles for Nanomedicines, DOI 10.1007/978-3-319-41421-8_4
16] Le Thi Mai Hoaet al J. Phys.: Conf. Ser. 2009 ; 187:012047.
17] María G. Nava-Arzaluz, Elizabeth Piñón-Segundo, Adriana Ganem-Rondero and David Lechuga-Ballesteros,Single Emulsion-Solvent Evaporation Technique and Modifications for the Preparation of Pharmaceutical Polymeric Nanoparticles, Recent Patents on Drug Delivery & Formulation, 2012; (6):209-223.
18] Hye-Young Kwon, Jun-Young Lee, Sung-Wook Choi, YangsooJang,Jung-Hyun Kim, Preparation of PLGA nanoparticles containing estrogen by emulsification–diffusion method, Colloids and SurfacesA: Physicochemical and Engineering Aspects, 2001; (182):123–130.
19] Elizabeth Pin˜o´n-Segundo, Viridiana G. Llera-Rojas, Gerardo Leyva-Go´mez, ZaidaUrba´n-Morla´n, Ne´ storMendoza-Mun˜ozand David Quintanar-Guerrero. The emulsification-diffusion polymeric nanoparticles: Two decades of research. Nanoscale Fabrication, Optimization, Scale-up and Biological Aspects of Pharmaceutical Nanotechnology.Elsevier Inc. 2018.DOI: http://dx.doi.org/10.1016/B978-0-12-813629-4.00002-4
20] Sovan Lal Pal, Utpal Jana, P. K. Manna, G. P. Mohanta, R. Manavalan. Nanoparticle: An overview of preparation and characterization. Journal of applied pharmaceutical science. 2011; 01(06):228-234.
21] Nicole Nilhant, Chnatalschugens, Christian Granfils, Robert Jerome and PholippeTeyssie.Polylactidemicroparticles prepared by double emulsion/evaporation technique. I. Effect of primary emulsion stability. Pharmaceutical research. 1994; 11(10):1479-1484.
22] Iqbal M, et al., Double emulsion solvent evaporation techniques used for drug encapsulation, Int J Pharmaceut, 2015. http://dx.doi.org/10.1016/j.ijpharm.2015.10.057
23] Moritz Beck-Broichsitter, Erik Rytting, Tobias Lebhardt, Xiaoying Wang, Thomas Kissel. Preparation of nanoparticles by solvent displacement for drug delivery: A shift in the “ouzo region” upon drug loading. European Journal of Pharmaceutical Sciences. 2010; (41):244–253.
24] A. Krishna Sailaja, P. Amareshwar, P. Chakravarty. Different techniques used for the preparation of nanoparticles using natural polymers and their application. International Journal of Pharmacy and Pharmaceutical Sciences. 2011; 3 (2):45-50.
25] Wen Fan, Wei Yan, ZushunXu, Hong Ni. Formation mechanism of monodisperse, low molecular weight chitosan nanoparticles by ionic gelation technique. Colloids and Surfaces B: Biointerfaces 2012; (90):21– 27.
26] SijumonKunjachan, Sajan Jose. Understanding the mechanism of ionic gelation for synthesis of chitosan nanoparticles using qualitative techniques.Asian Journal of Pharmaceutics - April-June 2010; 148-153.
27] Trucillo P, Campardelli R, Production of Solid Lipid Nanoparticles with a Supercritical Fluid Assisted Process, The Journal of Supercritical Fluids (2018), https://doi.org/10.1016/j.supflu.2018.08.001
28] K. Byrappa, S. Ohara, T. Adschiri. Nanoparticles synthesis using supercritical fluid technology – towards biomedical applications.Advanced Drug Delivery Reviews 2008; (60):299–327.
29] Jaspreet K Vasir & Vinod Labhasetwa. Polymeric nanoparticles for gene delivery. ExpertOpin.Drug Deliv. (2006); 3(3):325-344.
30] Jie Chen, Zhaopei Guo, HuayuTian and Xuesi Chen.Production and clinical development of nanoparticles for gene delivery.Molecular Therapy — Methods & Clinical Development. 2016;(3), 16023; doi:10.1038/mtm.2016.23
31] Re F, et al. Nanotechnology for neurodegenerative disorders. Maturitas (2012), doi:10.1016/j.maturitas.2011.12.015
32] Cl´audiaSaraiva, CatarinaPraca, Raquel Ferreira, Tiago Santos, Lino Ferreira, Liliana Bernardino, Nanoparticle-mediated brain drug delivery: Overcoming blood-brain barrier to treat neurodegenerative diseases, Journal of Controlled Release (2016), doi: 10.1016/j.jconrel.2016.05.04
33] Randall Toy, Lisa Bauer, Christopher Hoimes, Ketan B. Ghaghada, EfstathiosKarathanasis. Targeted nanotechnology for cancer imaging. Advanced Drug Delivery Reviews. 2014; (76):79–97.
34] Satish K Nune, PadmajaGunda, Praveen K Thallapally, Ying-Ying Lin, M Laird Forrest, & Cory J Berkland. Nanoparticles for biomedical imaging.Expert Opin.Drug Deliv. (2009); 6(11):1175-1194.
35] Rajesh Singh, James W. Lillard Jr. Nanoparticle-based targeted drug delivery. Experimental and Molecular Pathology. 2009; (86):215-223.
Statistics
54 Views | 85 Downloads
How to Cite
Saokar, S., & Saudagar, R. (2019). Nanoparticle in Pharmaceutical Drug Delivery System: A Review. Journal of Drug Delivery and Therapeutics, 9(3), 543-548. https://doi.org/10.22270/jddt.v9i3.2772