Formulation and Evaluation of Transdermal Patch for Atomoxetine hydrochloride
The aim of this study was to develop transdermal patch of Atomoxetine hydrochloride which has good mechanical properties. The transdermal patches were preapared used solvent casting method. Different groups of films with drug were prepared using different amalgamations of polymers such as HPMC (various grades), Polyox303, Eudragit RL 100.Considering solubility of drug and polymer, the solvent system of water: ethanol was chosen.In-vitro release of drug substance was performed using phosphate buffer solution (PBS) pH 7.4. Compatibility of drug with different excipient (drug: excipient in the ratio 1:1) was carried out using Fourier Transform Infra-Red Spectroscopy (FTIR). Evaluation test such as weight variation, content uniformity, drug content, folding endurance, thickness, in-vitro dissolution and in-vitro disintegration were done. The folding endurance of the all batches found less than 500 times.The percentages of drug distribution was found in between 72 to 100%.The formulation F4 containing a combination of HPMC and Eudragit showed maximum drug release of 95.26%. The method employed to prepare patches was capable of producing patches with almost uniform drug distribution. Stability studies were conducted as per ICH guidlines (40±2○C at 75±5% RH) for optimized formulations and was found to be stable.
Keywords: Atomoxetine hydrochloride, Transdermal Patch
2. Lakshmi P.K, Malavika P, Vidya K, Formulation and Evaluation of oral films of Atomoxetine hydrochloride, International Research Journal of pharmacy, 2018; 9(9):105- 109.
3. Jeffery H Newcorn MD, Thomas J Spencer M.D ,Joseph Bierdman MD , Ms. Milton Dr. Michelson, Atomoxetine Treatment in Children and Adolescents With Attention-Deficit/Hyperactivity Disorder and Comorbid Oppositional Defiant Disorder , Journal of American Academy of child and Adoloscent psychiatry,2005; 44(3):240-48.
4. Leslie Briars and Timothy Todd, A review of pharmacological management of Attention Deficiet/ Hypercativity disorder, Journal of pediatric pharmacology and therapeutics, 2016; 21(3):192-206.
5. Abhilash M, Senthil Kumar S, Parthiban S, Effect of Chemical Penetration Enhancers On The Transdermal Patches Of Nimodipine, International Journal of Advanced Pharmaceutics, 2013; 3 (2):65-69.
6. Patel RP, Baria AH., Formulation and Evaluation consideration of transdermal drug delivery system, Interanational Journal of Pharmaceutical Research, 2011; 3:1-9.
7. Kunal N Patel, Hetal K Patel, Vishnu A Patel, Formulation And Characterization Of Drug In Adhesive Transdermal Patches Of Diclofenac Acid, International Journal of Pharmacy and Pharmaceutical Sciences, 2012 ; 4(1):296-99.
8. M. Bharkatiya, R. K. Nema, M. Bhatnagar, Designing and Characterization of Drug Free Patches for Transdermal Application, International Journal of Pharmaceutical Sciences and Drug Research, 2010; 2(1):35-39.
9. Lakshmi P K, Sreekanth J, Aishwarya Sridharan, Formulation development of fast releasing oral thin films of levocetrizine dihydrochloride with Eudragit® Epo and optimization through Taguchi orthogonal experimental design, Asian Journal of Pharmaceutics, 2011; 5:84-92.
10. Denge MS, Walde SR, Ittadwar AM, Development and Characterization of Transdermal Patches Of Ondansetron Hydrochloride,International Journal of Pharmacy and Pharmaceutical Sciences, 2012; 4(5):293-98.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).