Development of Liquid and Solid Self-Emulsifying Drug Delivery System of Silymarin
The objective of our investigation was to formulate a self-emulsifying drug delivery system (SEDDS) of Silymarin using minimum surfactant concentration that could include its solubility, stability and also oral bioavailability. Silymarin are widely use drug for the treatment of hepatitis C virus, have poor bioavailability due to their poor water solubility that limits dissolution rate. To overcome this limitation SEDDS were prepared to attempt their release property. The solubility of the drug was determined by various vehicles. Ternary phase diagram was constructed using Cinnamon (oil), Tween 20 (surfactant) and PEG 200 (co-surfactant) and water to identify the efficient Self-emulsifying region. Through pseudo ternary phase diagram investigation, four different formulations were prepared of liquid-solid SEDDS. The stability can be achieved more by developing the solid dosage form by converting the liquid SEDDS to solid SEDDS formulation. The liquid SEDDS was converted into free flowing powder by adsorption of liquid onto solid carriers by using Aerosil 200 that provides a high surface area. The in vitro release of solid SEDDS was 58.16% within 8 h. The optimized formulation (F1) showed higher dissolution release than the commercial product. The in vitro drug release kinetics study of optimized formula was found better Regression coefficient (R2) compare with other formulation. In conclusion the study elucidated that adsorption to solid carrier technique could be useful method to prepare the solid SEDDS from liquid SEDDS, which can improve oral absorption of Silymain.
Keywords: Silymarin, Self emulsifying drug delivery system, Cinnamon oil, Tween 20, PEG 200.
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