A Review: Formulation and Characterization of Fast Dissolving Tablet of Carvidilol
Abstract
Carvedilol a poorly water soluble drug undergoes extensive first pass metabolism, which reduces its bioavailability to 25-30%. Fast dissolving tablets of Carvedilol were prepared with the purpose of delivering the drug directly into the systemic circulation and bypassing the hepatic first pass metabolism with a concomitant increase in bioavailability. The solubility of Carvedilol was improved by forming inclusion complex with cyclodextrin which was then further used for the formulation of Fast dissolving tablet.
Keywords: Carvedilol, Superdisintegrats, Fast dissolving Tablets and FDTs.
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References
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19. Ahmed I. S.; Nafadi M. M.; Fatahalla F. A. “Formulation of a Fast-Dissolving Ketoprofen Tablet Using Freeze-Drying in Blisters Technique”, Drug Dev and Ind Pharm, 2006; 32(4):437-442
20. Kaushik D, Dureja H, Saini T.R., Mouth Dissolving Tablets: A review. Indian Drugs, 2004; 41(4):187-193.
21. Mishra DN, Bimodal M, Singh SK, Vijaya Kumar SG. Spray dried excipient base: a novel technique for the formulation of orally disintegrating tablets. Chem Pharm Bull 2006; 54(1):99-102.
22. Bhowmik D., et al. Fast Dissolving Tablet: An Overview. Journal of Chemical and Pharmaceutical Research, 1(1): 2009; 163-177.
23. Allen LV, Wang B, Davis JD. Rapidly dissolving tablet. US patent 5, 807, 576; 1998.
24. Pebley WS, Jager NE, Thompson SJ. Rapidly disintegrating tablet. US Patent 5, 298, 261; 1994.
25. Myers GL, Battist GE, Fuisz RC, US Patent 5,871,781, Feb 16, 1999.
26. Abdelbery G, Prinderre P, Eouani C, Joachim J, Reynier JP, Piccerelle P. The preparation of orally disintegrating tablets using a hydrophilic waxy binder. Int .J .Pharm. 278(2): 2004; 423-433
2. Habib, W., Khankari, R., Hontz, J., Fast-dissolving drug delivery systems, critical review in therapeutics, Drug Carrier Systems, 17(1), 2000, 61-72
3. Dobetti, L., Fast-Melting Tablets: Developments and Technologies, Pharm. Tech., (Suppl.), 2001, 44-50.
4. Chang, R., Guo, X., Burnside, B. A., Couch, R., Fast-dissolving tablets, Pharm. Tech.,24(6) , 2000,52-58.
5. Shukla D, Chakraborty S, Mouth dissolving tablets: An overview, Formulation Technology, Sci Pharm, 2009; 76; 306-329
6. Zoghbi A, Wang B, Carvedilol solubility enhancement by inclusion complexation and solid dispersion: review. Journal of Drug Delivery and Therapeutics, 2015; 5(2):1-8.
7. Momin S, Khan S, Ghadage D, Yadav A, Wagh A, Formulation and evaluation of bilayer tablets of propranolol hydrochloride. Journal of Drug Delivery and Therapeutics, 2017; 7(2):50-57.
8. Fix JA. Advances in quick-dissolving tablets technology employing Wowtab. Paper presented at: IIR Conference of drug delivery systems. 1998 Oct.; Washington DC, USA.
9. Virely P, Yarwood R. Zydis-a novel, fast dissolving dosage form. Manuf. Chem. 1990; 61:36-37.
10. http://www.pharmpedia.com/Tablet:Formulation of tablets Disintegrants
11. Masuda T, Takahashi O, JP 61,268,619, November 28, 1986.
12. Block J, Cassiere A, Christen MO, DE3900811, July 19, 1990.
13. Yajima T, Chem. Pharm. Bull., 1997, 44, 187–191
14. Kurasumi T, Imamori K, Iwasa A, JP 03,236,316, October 22, 1991
15. Honeysett RA, Freely LC, Hoadley TH, Sims EE, EP0501763, September 2, 1992.
16. Gohel M, Patel M, Amin A, Agrawal R, Dave R, Bariya N. Formulation Design and Optimization of Mouth Dissolve Tablets of Nimesulide Using Vacuum Drying Technique. AAPS PharmSciTech. 2004; 5(3).
17. Reddy, L. H., Ghosh, B., and Rajneesh, 2002, Fast dissolving drug delivery systems: a review of the literature, Indian J. Pharm. Sci., 64(4), 331-336.
18. Remon JP. Correleyn s 2000, Freeze dried disintegrating tablets US patent 6010719 Jan 2000.
19. Ahmed I. S.; Nafadi M. M.; Fatahalla F. A. “Formulation of a Fast-Dissolving Ketoprofen Tablet Using Freeze-Drying in Blisters Technique”, Drug Dev and Ind Pharm, 2006; 32(4):437-442
20. Kaushik D, Dureja H, Saini T.R., Mouth Dissolving Tablets: A review. Indian Drugs, 2004; 41(4):187-193.
21. Mishra DN, Bimodal M, Singh SK, Vijaya Kumar SG. Spray dried excipient base: a novel technique for the formulation of orally disintegrating tablets. Chem Pharm Bull 2006; 54(1):99-102.
22. Bhowmik D., et al. Fast Dissolving Tablet: An Overview. Journal of Chemical and Pharmaceutical Research, 1(1): 2009; 163-177.
23. Allen LV, Wang B, Davis JD. Rapidly dissolving tablet. US patent 5, 807, 576; 1998.
24. Pebley WS, Jager NE, Thompson SJ. Rapidly disintegrating tablet. US Patent 5, 298, 261; 1994.
25. Myers GL, Battist GE, Fuisz RC, US Patent 5,871,781, Feb 16, 1999.
26. Abdelbery G, Prinderre P, Eouani C, Joachim J, Reynier JP, Piccerelle P. The preparation of orally disintegrating tablets using a hydrophilic waxy binder. Int .J .Pharm. 278(2): 2004; 423-433
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1.
Sharma A, Gupta AK, Gupta MK, Sharma V. A Review: Formulation and Characterization of Fast Dissolving Tablet of Carvidilol. JDDT [Internet]. 22May2019 [cited 24Feb.2020];9(3):749-52. Available from: http://jddtonline.info/index.php/jddt/article/view/2738
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Review
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