Synthesis and Biological Evaluation of pyrazole derivatives containing ethanone skeleton as Anti-inflammatory agents
Current research had focused on the synthesis of the novel pyrazole ethanone linked compounds with improved biological activity. In this synthetic process 1st step was to synthesize the intermediate chalcone and 2nd step was the synthesis of final compound pyrazole derivative containing ethanone moiety. This procedure is the type of cyclization reaction using proton transfer mechanism. By using this method 8 derivatives synthesized. After synthesis these were subjected to identification tests by using various methods like melting point study, thin layer chromatography, solubility study and characterization by using UV, IR and NMR Spectroscopy.
Keywords: Selective COX-2 inhibitor, anti-inflammatory, pyrazole ethanone linked compounds, pyrazole derivatives, inflammation
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