Synthesis and Biological Evaluation of pyrazole derivatives containing ethanone skeleton as Anti-inflammatory agents

  • KHUSHBOO MISHRA Department of Pharmacy, Bundelkhand University, Jhansi, U.P.
  • S. K. Jain Department of Pharmacy, Bundelkhand University, Jhansi, U.P.
  • P. K. Singour Computational & Synthetic Chemistry Division, Department of Pharmaceutical Chemistry, VNS Institute of Pharmacy, Neelbud, Bhopal, (M.P.) India

Abstract

Current research had focused on the synthesis of the novel pyrazole ethanone linked compounds with improved biological activity. In this synthetic process 1st step was to synthesize the intermediate chalcone and 2nd step was the synthesis of final compound pyrazole derivative containing ethanone moiety. This procedure is the type of cyclization reaction using proton transfer mechanism.  By using this method 8 derivatives synthesized.  After synthesis these were subjected to identification tests by using various methods like melting point study, thin layer chromatography, solubility study and characterization by using UV, IR and NMR Spectroscopy.


Keywords: Selective COX-2 inhibitor, anti-inflammatory, pyrazole ethanone linked compounds, pyrazole derivatives, inflammation

Downloads

Download data is not yet available.

Author Biographies

KHUSHBOO MISHRA, Department of Pharmacy, Bundelkhand University, Jhansi, U.P.

Department of Pharmacy, Bundelkhand University, Jhansi, U.P.

S. K. Jain, Department of Pharmacy, Bundelkhand University, Jhansi, U.P.

Department of Pharmacy, Bundelkhand University, Jhansi, U.P.

P. K. Singour, Computational & Synthetic Chemistry Division, Department of Pharmaceutical Chemistry, VNS Institute of Pharmacy, Neelbud, Bhopal, (M.P.) India

Computational & Synthetic Chemistry Division, Department of Pharmaceutical Chemistry, VNS Institute of Pharmacy, Neelbud, Bhopal, (M.P.) India

References

1. Rainsford KD. The Ever emerging Anti-inflammatory Journal of Physiology Paris, 2001; 95:11-19.
2. Sujatha K and Perumal PT and Muralidharan D and Rajendran M. Synthesis, analgesic and anti-inflammatory activities of bis(indolyl)methanes” Indian Journal of Chemistry, 2009; 48:267-272.
3. Dhondge R and Chaturvedi SC. QSAR analysis of 2-sulfonylphenyl-3-phenyl-indole derivatives as novel anti-inflammatory compounds Medicinal Chemistry Research 2009; 18:167-178.
4. Zarghi A and Ghodsi R and Azizi E and Daraie B and Hedayati M and Dadrass OG. Synthesis and biological evaluation of new 4-carboxyl quinoline derivatives as cyclooxygenase-2 inhibitors Bioorganic & Medicinal Chemistry, 2009b; 17:5312.
5. Schuhly W and Hufner A and Pferschy-Wenzig EM and Prettner E and Adams M and Bodensieck A and Kunert O and Oluwemimo A and Haslinger E and Bauer R. Design and synthesis of ten biphenyl-neolignan derivatives and there in vitro inhibitory potency against cyclooxygenase-1/2 activity and 5-lipoxygenase-mediated LTB4-formation Bioorganic & Medicinal Chemistry, 2009; 17:4459-4465.
6. Girgis AS and Barsoum FF. Synthesis of [1, 2, 4]triazolo[1,5-a]pyridines of potential PGE2 inhibitory properties European Journal of Medicinal Chemistry, 2009; 44:1972-1977.
7. Kouatly O and Geronikaki A and Kamoutsis C and Hadjipavlou-Litina D and Eleftheriou P. Adamantane derivatives of thiazolyl-N-substituted amide, as possible non-steroidal anti-inflammatory agents European Journal of Medicinal Chemistry, 2009; 44:1198-1204.
8. Sondhi SM and Dinodia M and Jain S and Kumar A. Synthesis of biologically active N-methyl derivatives of amidines and cyclized five-membered products of amidines with oxalyl chloride European Journal of Medicinal Chemistry 2008; 43:2824-2830.
9. Navidpour L and Shadnia H and Shafaroodi H and Amini M and Dehpourd AR and Shafieea A. Design, synthesis and biological evaluation of substituted 2-alkylthio-1,5-diarylimidazoles as selective COX-2 inhibitors Bioorganic & Medicinal Chemistry 2007; 15:1976-1982.
10. Karthikeyan MS. Synthesis, analgesic, anti-inflammatory and antimicrobial studies of 2,4-dichloro-5-fluorophenyl containing thiazolotriazoles European Journal of Medicinal Chemistry, 2009; 44:827-833.
11. Lv P and Li H and Juan S and Yang Z and Zhu H. Synthesis and biological evaluation of pyrazole derivatives containing thiourea skeleton as anticancer agents Bioorganic & Medicinal Chemistry 2010; 18 (1):4606-4614.
Statistics
45 Views | 88 Downloads
How to Cite
MISHRA, K., Jain, S. K., & Singour, P. K. (2019). Synthesis and Biological Evaluation of pyrazole derivatives containing ethanone skeleton as Anti-inflammatory agents. Journal of Drug Delivery and Therapeutics, 9(3), 40-47. https://doi.org/10.22270/jddt.v9i3.2736