Method development and validation of Sofosbuvir and iedipasvirin by HPLC: A Review

  • Sagar Ramdas Vidhate Rajgad Dnyanpeeth’s College of Pharmacy, Bhor, Pune, Maharashtra 412206, India
  • Vaibhavi Vasant Kunjir Rajgad Dnyanpeeth’s College of Pharmacy, Bhor, Pune, Maharashtra 412206, India
  • Rajkumar V. Shete

Abstract

The aim of this review article is emphasizing on development and validation protocol which will used to develop and validate accurate, simple, selective and specific spectrophotometric methods for the determination of Sofosbuvir (SOF) and Ledipasvir (LDV) in pure and in their dosage forms. Thus it is necessary to develop methods for analysis with the help of number of analytical techniques which are available for the estimation of the drugs in combination. The analyst were determine the Specific, accurate, simple, selective and stability-indicating RP-HPLC method is developed and validated for simultaneous determination of sofosbuvir and ledipasvir in tablet dosage form.


Keywords: Sofosbuvir, Ledipasvir, RP-HPLC, Method development, Method validation.

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Author Biographies

Sagar Ramdas Vidhate, Rajgad Dnyanpeeth’s College of Pharmacy, Bhor, Pune, Maharashtra 412206, India

Rajgad Dnyanpeeth’s College of Pharmacy, Bhor, Pune, Maharashtra 412206, India

Vaibhavi Vasant Kunjir, Rajgad Dnyanpeeth’s College of Pharmacy, Bhor, Pune, Maharashtra 412206, India

Rajgad Dnyanpeeth’s College of Pharmacy, Bhor, Pune, Maharashtra 412206, India

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How to Cite
Vidhate, S. R., Kunjir, V. V., & Shete, R. V. (2019). Method development and validation of Sofosbuvir and iedipasvirin by HPLC: A Review. Journal of Drug Delivery and Therapeutics, 9(3), 745-748. https://doi.org/10.22270/jddt.v9i3.2726