Nanoparticles: A Novel Approach for Targeted Delivery of Medicines
The utilization of nanotechnology in medicine and all the more explicitly tranquilize conveyance is resolved to spread quickly.Right now numerous substances are under scrutiny for medication conveyance and all the more explicitly for disease treatment Strangely pharmaceutical sciences are utilizing nanoparticles to lessen lethality and reactions of medications and up to as of late did not understand that bearer frameworks themselves may force dangers to the patient.The sort of risks that are presented by utilizing nanoparticles for medication conveyance are past that presented by customary perils forced by synthetic concoctions in established conveyance frameworks. For nanoparticles the learning on molecule danger as got in inward breath poisonous quality tells the way the best way to examine the potential risks of nanoparticles. The toxicology of particulate issue contrasts from toxicology of substances as the making chemical(s) could conceivably be dissolvable in natural frameworks, therefore impacting extraordinarily the potential presentation of different inside organs. This may differ from a fairly high neighborhood introduction in the lungs and a low or neglectable presentation for other organ frameworks after inward breath. Be that as it may, ingested species may likewise impact the potential harmfulness of the breathed in particles. For nanoparticles the circumstance is distinctive as their size opens the potential for intersection the different organic boundaries inside the body. From a positive perspective, particularly the possibility to cross the blood cerebrum hindrance may open new ways for medication conveyance into the mind. Likewise, the nanosize additionally takes into consideration access into the cell and different cell compartments including the core. A large number of substances are right now under scrutiny for the arrangement of nanoparticles for medication conveyance, differing from organic substances like egg whites, gelatin and phospholipids for liposomes, and more substances of a concoction nature like different polymers and strong metal containing nanoparticles. This paper gives a diagram on a portion of the right now utilized frameworks for medication conveyance.
3. You Han Bae, Kinam park, Targeted Drug Delivery to tumors; Myths, reality, possibility, science direct, 2011; 153:198-205.
4. Pal SL, Jana U, Manna PK, Mohanta GP, Manavalan R, An overview of preparation and charecterization of nanoparticles, Journal of Applied Pharmaceutical Science, 2011; 1(6): 228-234.
5. Mosami H. kanami, Vadaliy KR, Nanoparticles as the precursors of the next technological revolution of the 21st century nanotechnology, 2012; 2(3):2247-4189.
6. Vyas SP, Khar A, Targeted and Controlled drug Delivery, CBS publication, 2004; 4th editon: 331-383.
7. Quintanar-Guerrero DA, E; Fessi, H; Doelker, E, Preparation techniques and mechanisms of formation of biodegradable nanoparticles from preformed polymers, Drug Dev Ind Pharm,1998; 24:1113-1128.
8. Solaro R, Nanostructured polymeric systems in targeted release of proteic drugs and in tissue engineering China-EU Forum on Nanosized Technology. China-EU Forum, Beijng, 2002
9. General S and Thunemann AF,pH-sensitive nanoparticles of poly (amino acid) dodecanoate complexes. Int. Pharm,2001; 230:11-24.
10. Mansouri S, Lavigne P, Corsi K, Benderdour M, Beaumont E and Fernandes JC, Chitosan-DNA nanoparticles as non-viral vectors in gene therapy: Strategies to improve transfection efficacy,Eur. Pharm Biopharm,2004; 57:1-8.
11. Janes KA, Calvo P and Alonso MJ , Polysaccharide colloidal particles as delivery systems for macromolecules, Adv Drug Del Rev, 2001;47:83-97.
12. Sun YP, Meziani MJ, Pathak P and Qu L, Polymeric nanoparticles from rapid expansion of supercritical fluid solution, Chemistry ,2005; 11:1366-1373.
13. Young TJ, Johnson KP, Pace GW and Mishra AK, Phospholipid-stabilized nanoparticles of cyclosporine A by rapid expansion from supercritical to aqueous solution, AAPS PharmSciTech, 2005; 5:E11.
14. Subramaniam B, Rajewski RA and Snavely K , Pharmaceutical processing with supercritical carbon dioxide,Pharm Sci, 1997;86:885-890.
15. Gokhale AA, Khushi B, Dave RN and Pfeffer R , Formation of polymer nanoparticles in supercritical fluid jets. Nanotech, 2005: (May).
16. Couvreur P, Polyalkylcyanoacrylates as colloidal drug carriers,Crit Rev Ther Drug Carr Syst,1998; 5:1-20.
17. Kreuter J, Evaluation of nanoparticles as drug-delivery system. I. Preparation methods, Pharm Acta Helv, 1983; 58:196- 209.
18. HM Redhead, SS Davis, L Illum , Drug delivery in poly(lactide-co-glycolide) nanoparticles surface modified with poloxamer 407 and poloxamine 908: in vitro characterisation and in vivo evaluation. J Control Release, 2001; 70: 353-363
19. Panyam J, Dali MM, Sahoo SK, W Ma, SS Chakravarthi, GL Amidon, RJ Levy, V Labhasetwar . Polymer degradation and in vitro release of a model protein from poly(,-lactide-co-glycolide) nano- and microparticles, J Control Release,2003; 92: 173- 187
20. Muller RH, Wallis KH, Surface modification of i.v.injectable biodegradable nanoparticles with poloxamer polymers and poloxamine 908, Int. J. Pharm,1993; 89: 25-31
21. Brigger I, C. Dubernet, P. Couvreur, Nanoparticles in cancer therapy and diagnosis, Adv. Drug Deliv,2002;Rev, 54:631-651.
22. Couvreur P, Barratt G, Fattal E, Legrand P, Vauthier C, Nanocapsule technology: a review,Crit Rev Ther Drug Carrier Syst,2002; 19: 99-134
23. Mohsen Jahanshahi, Zahra Babaei, Protein nanoparticle: A unique system as drug delivery vehicles, African Journal of Biotechnology ,2008; 7 (25):4926-4934
24. Fresta M, Puglisi G, Giammona G, Cavallaro G, N Micali, PM Furneri, Pefloxacin mesilate- and ofloxacinloaded polyethylcyanoacrylate nanoparticles; characterization of the colloidal drug carrier formulation, J. Pharm. Sci,1995; 84:895-902.
25. Chen Y, McCulloch RK, Gray BN, Synthesis of albumin-dextran sulfate microspheres possessing favourable loading and release characteristics for the anti-cancer drug doxorubicin, J Control Release, 1994; 31: 49-54.
26. Maruthi.G, Anton.A, Smith.R.Maravalan. Nanoparticles: Rev,J asr.rev, 2011;2(4):12-19.
27. Melcolm A Alison;Cancer,an introductory article.encyclopedia of life sciences ,2001.
28. Shikanov A, Vaisman B, Krasko MY, Nyska A, Domb AJ,Poly(sebacic acid- coricinoleic acid) biodegradable carrier for paclitaxel: in vitro release and in vivo toxicity,J Biomed Mater Res, 2004 ; 69(A):47-54.
29. Yun Hwan Ju, Inyu Jung, chung Seok Chol, Inoung Kim, and Hyuck mo Lee, Synthesis characterization of low Temperature Sn Nano particle,2011; Research:22:22561.
30 Subhedi RK, Kang KW, Hoo-Kyumehoi,preparation and characterization of SLN loaded with Doxorubicin,ejps, 2011;37:508-513.
31 Badawi AA, EI-Narbarawi MA,EI-Setouhyda, Alsammits, Formulation and stability testing of Itraconazole crystalline nano particles. Research article, 2011; 12(3):811-20.
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