Development of sustained release hydrophobic emulgel for oral care
Abstract
The objective of the study is to formulate the emulgel of Doxycyclin hyclate and Eugenol for sustained or controlled release gel for oral care. Doxycyclin hyclate is an antibiotic which belongs to chemical class tetracyclines and widely used in treatment of oral care bacterial infections. Eugenol oil is extracted from the clove and act as good analgesic and anti-inflammatory. The combination of Doxycyclin hyclate and eugenol can be formulated for better oral care treatment. The compatibility study performed of drug and drug-polymer by IR spectra indicates good compatibility. The simple manufacturing method is employed as hot emulsification. The formulations were evaluated for description, pH, viscosity, spreadability, extrudability, % drug content and content uniformity. Optimized formulations were evaluated for In-vitro release, antibacterial activity, and stability study. Formulated formulations were complying with all the evaluation parameters. The highest drug release found with the formulation OFEG 01 and OFEG 06. The formulations OFEG 06 is the most stable formulation in stability at accelerated, intermediate and room temperature storage condition for 3 months.
Keywords: Emulgel, Oral Care, Doxycyclin and Eugenol
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