Ethosomes: Transdermal Drug Delivery System

  • Nilesh V Pakhale Department of Pharmaceutics, R.G. Sapkal College of Pharmacy, Anjaneri-4222213, dist. Nashik, Maharashtra, India
  • S.B. Gondkar Department of Pharmaceutical chemistry, R.G. Sapkal College of Pharmacy, Anjaneri-4222213, dist. Nashik, Maharashtra, India
  • R.B. Saudagar Department of Pharmaceutical chemistry, R.G. Sapkal College of Pharmacy, Anjaneri-4222213, dist. Nashik, Maharashtra, India

Abstract

The skin is one of the most extensive and readily accessible organs of the human Body. One of the greatest disadvantages to transdermal drug delivery is the skin's low permeability that limits the number of drugs that can be delivered in this manner. Ethosomes as novel vesicles in transdermal drug delivery show significant effects on drug penetration through the biological membrane. Now-a-days we better know vesicles have importance in cellular communication. Ethosomes, Although ethosomes are conceptually sophisticated, they are simple inpreparation and safe for use. Transdermal route is promising alternative to drug delivery for systemic effect. An attempt was made to formulate the highly efficient ethosomal drug delivery system and enalapril meleate is used as model drug. Ethosomes have higher penetration rate through the skin as compared to liposomes hence these can be used widely in place of liposomes. Ethosomes enhanced skin permeation, improved drug delivery, increased drug entrapment efficiency etc Ethosomes have become an area of research interest, because of its enhanced skin permeation, improved drug delivery, increased drug entrapment efficiency etc. The purpose of writing this review on ethosomes drug delivery was to compile the focus on the various aspects of ethosomes including their mechanism of penetration, preparation, advantages, composition, characterization, application and marketed product of ethosomes. Characterizations of ethosomes include Particle size, Zeta potential, Differential Scanning Calorimertry, Entrapment efficiency, Surface tension activity measurement, Vesicle stability and Penetration Studies etc.


Keywords: Transdermal Drug Delivery System, Ethosomes, Drug absorption 

Downloads

Download data is not yet available.

Author Biographies

Nilesh V Pakhale, Department of Pharmaceutics, R.G. Sapkal College of Pharmacy, Anjaneri-4222213, dist. Nashik, Maharashtra, India

Department of Pharmaceutics, R.G. Sapkal College of Pharmacy, Anjaneri-4222213, dist. Nashik, Maharashtra, India

S.B. Gondkar, Department of Pharmaceutical chemistry, R.G. Sapkal College of Pharmacy, Anjaneri-4222213, dist. Nashik, Maharashtra, India

Department of Pharmaceutical chemistry, R.G. Sapkal College of Pharmacy, Anjaneri-4222213, dist. Nashik, Maharashtra, India

R.B. Saudagar, Department of Pharmaceutical chemistry, R.G. Sapkal College of Pharmacy, Anjaneri-4222213, dist. Nashik, Maharashtra, India

Department of Pharmaceutical chemistry, R.G. Sapkal College of Pharmacy, Anjaneri-4222213, dist. Nashik, Maharashtra, India

References

1. Aggrawal D, Nautiyal U, ''Ethosomes: A review'', International Journal of Pharmaceutical and medicinal Research 201;, 4(4):354-363
2. Sujatha V, Vishnuvaravidyadhar T, Parvathi M, Srauryapkash Reddy,'' A Review on Transdermal Drug Delivery System by Ethosomes'',Pharmatutor:2014; 2(2):50-55
3.Tarun Parashar, Soniya,Roopesh Sanchan, Vishal Singh, Anil Gupta,''Ethosomes: a Recent Vesicles of Tdds , International Journal of Research and Development in Pharmacy and Life Sciences,feb-march2013,PP 285-292
4 . Tiwari A, Mishra MK, Shukla A, '' Ethosomes :a Novel Vesicular Carrier System for Therapeutic Applications'', IOSR journal of Pharmacy 2016; 25-33
5. Prasad.V.Patrekar, Suhel.j.inamdar ,Amita.A .Aahir, Avinash H.Hosmani,'' Ethosomes as Novel Drug Delivery System: the Pharma Innovation journal 2015:4(9)10-21
6. Aute PP, Kamble MS, Bhosale AV, ''a Comprehensive review on Ehosomes'',International journal of Research and Development in Pharmacy and Life Science, 2012; 218-224
7. Mishra DK, Balekar N, Dhote V, Ethosomes: a Navel Carrier for Dermal or Transdermal Drug Delivery ,pp.357-383
8. Nandure HP, Puranik P, Lane V, Ethosomes: a Novel Drug Carrier ,International Journal of Pharmaceutical Research Schlors 2013,pp.18-30
9. Chandel A, Patil V, Goyal R, Hitesh Dhamija, Ethosomes: a Novel Approch Toward Transdermal Drug delivery, International Journal of Pharmaceutical and Chemical Science, 2012; 563-569
10.Ghule AR,, ShinkarDM, Saudagar RB, Ethosomes: Carrier for Enhanced Transdermal Drug Delivery System, Journal of Advanced Pharmacy Education and Research, 2014; 4:380-387
11. Dayan ETN, Godin B, Ethosomes-Novel Vesicular Carrier for Enhanced Delivery ,Characterization and Skin Penetration Properties, Journal of Controlled Release GT2000; 403-418
12. Jaiswal P, Kesharwani S, Kesharwani R, Patel D, Ethosome: A New Technology Used As Topical & Transdermal Delivery System. Journal of Drug Delivery and Therapeutics, 2016; 6(3):7-17.
13. Vishvakrama P, Sharma S, Liposomes: An Overview. Journal of Drug Delivery and Therapeutics, 2014; 47-55.
Statistics
37 Views | 65 Downloads
How to Cite
Pakhale, N. V., Gondkar, S., & Saudagar, R. (2019). Ethosomes: Transdermal Drug Delivery System. Journal of Drug Delivery and Therapeutics, 9(3), 729-733. https://doi.org/10.22270/jddt.v9i3.2692