Evaluation of hair growth promoting activity of petroleum ether extracts of Hemidesmus indicus Linn. (Seed) on Wistar Albino rats
In present investigation was carried out to screening of hair growth promoting potentiality of petroleum ether extract of Hemidesmus indicus Linn. (Seeds). Preliminary chemical tests and TLC analysis revealed the presence flavonoids and saponins. Hair growth promoting activity of petroleum ether of Hemidesmus indicus was screened by considering different parameters which included time taken for covering bald patch, length of hair produced, percentage of hair follicles in anagen and telogen phases, time of hair growth initiation and completion and level of minerals in blood. The petroleum ether extract of Hemidesmus indicus showed a very good hair growth promoting activity at a dose of 300 mg/kg which was comparable to that of 2% minoxidil. After 30 days of treatment with test and standard drugs it was observed that, time taken for covering the bald patch, hair growth initiation and completion time and quantitative hair growth were found to be comparable to that of the standard drug. An increase in percentage of hair follicles turning from telogen phase to anagen phase was noted. The control treated group of animals showed poor hair growth for all the parameters.
Keywords: Hemidesmus indicus Linn., Anagen, Catagen, Telogen, Minoxidil.
2. Roy RK, Thakur M, Dixit VK, Effect of Cuscutareflera Roxbon hair growth activity of albino rats, Indian Drugs, 2006; 43(1), 951-956.
3. Hoffman R, Happle R, Current understanding of androgeneticalopecia, part Ii: clinical aspects and treatment. European J. of dermatol., 2000; 10(5), 454-467.
4. Jackson BP, Snowden DW, Atlas of Microscopy of Medicinal plants, culinary herbs and species, CBS publication, New delhi, 2000; 72, 100.
5. Aneesh TP, Moharned Hisham M. Sonalsekhar, Manjusree Madhu, Intemational market scenario of traditional Indian herbal drugs, International general of green pharmacy, 2009; 3(3), 181-191.
6. Chopra RN, Nayer SL, Chopra IC, Glossary of Indian medicinal plants, Publication and Information Directorate, CSIR, New Delhi, 1986; 85.
7. Roy RK, Thakur M, Dixit VK, Effect of Citrullus colocynthis on Hair Growth in Albino Rats, pharmaceutical biology, 2007;45(10), 739-744.
8. Saraf S. Pathak AK, Dixit VK, Hair growth promoting activity of Tridax procumbens, Fitpterapia, 1991; 62, 495-498.
9. Adthirajan N. Ruvi Kumar T. Shanmugosundlaram N, Mary B, In vivo and in vitro evaluation of hair growth potential of hibiscusrosa-sinessio Linn. J Ethnopharmacol, 2003; 88, 235-239
10. Ebling FIG, The biology of hair, Dermatol. Clin, 1987; 5, 467-481.
11. Goodman Gillman A, Limbird L.E. Harman J.G, The pharmacological basis of therapeutics 10th edition, 2001; 573-574, 690.
12. Takahashi T, Kamiya T, Yokoo Y. Proanthocynanidins from grape seeds promote proliferation of mouse hair follicle cells in vitro and convert hair cycle In vivo, Acta DermVenereol (Stockh) 1998; 78, 428-432.
13. Tanaka S, Saito M, Tabata M. Bioassay of crude drugs for Hair growth promoting activity in mice by a new simple method. Planta Med Suppl 1980; 1, 84-90.
14. Roy RK. Thakur M. Dixit VK, Development and performance evaluation of herbal formulation for hair growth promoting activity, J Cosmet Dermatol, 2007; 6(2), 108-112.
15. Thorat RM, Jhadav VM, Kadam VJ, Development and Evaluation of polyherbal formulations or hair growth – promoting activity, International Journal of Pharma Tech Research, 2009; 14, 1251-1254.
16. Patni P, Varghese D, Balekar N, Jain K, Formulation and evaluation of herbal hair oil for alopecia managememt, plant indica. 2006; 2, 27-30.
17. Pandit S, Chauhan N, Dixit VK, Effect of Cuscutare flexa Roxb on androgen-induced alopecia, Joumal of cosmetic dermatology, 2008; 7, 190-201.
18. Price VH, Treatment of hair loss, N. Engl. J. Med. 1999; 341: 964-973.
19. Purwal L, Prakash S, Gupta BN, Pande MS, Development and Evaluation of Herbal Formulation for Hair Growth, E-Journal of Chemistry, 2008; 5, 34-38.
20. Paus R, Therapeutic strategies for treating hair loss, Drug Discovery Today, Therapeutic Strategies, 2006; 3,107-110.
21. Chunekar KC, Hota NP, Plants of Bhavprakash, National Academy of Ayurveda, New Delhi, 1986; 1, 126.
22. Libecco JF, Bergfeld W, Finasteride in the treatment of alopecia, Expert Opin Pharmacother, 2004; 5(4).933-940.
23. Messenger AG, Medical management of male pattern hair lossint. J. Dermatol, 2000; 39. 585-586.
24. Norwood OT, Incidence of female androgenetic alopecia (female pattern alopecia), Dermatol, Surg: 2001, 27, 53-54
25. Adhirajan ND, NiIr VK, Gown C, Development and evaluation of herbal formulations for hair growth, Indian Drugs, 2001; 38(11), 559-563.
26. Roy RK, Thakur M, Dixit VK,Development and evaluation of Polyherbal formulation for hair growth promoting activity, Jourmal of Cosmetic Denmatology, 2007; 6, 108-112.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).