Review on Sublingual Drug Delivery System

  • Sanjana Labhade MET’s Bhujabal Knowledge City, Institute of Pharmacy, Adgaon, Nashik-422003, India
  • Chaitali Malode MET’s Bhujabal Knowledge City, Institute of Pharmacy, Adgaon, Nashik-422003, India
  • Vaishali Rawal MET’s Bhujabal Knowledge City, Institute of Pharmacy, Adgaon, Nashik-422003, India
  • Smita Rupvate MET’s Bhujabal Knowledge City, Institute of Pharmacy, Adgaon, Nashik-422003, India

Abstract

Drug delivery via the oral mucous membrane is considered to be a promising alternative to the oral route. Sublingual route is a useful when rapid onset of action is desired with better patient compliance than orally administered drugs. In terms of permeability, the sublingual area of the oral cavity is more permeable than the buccal area, which in turn is more permeable than the roof of the mouth area. The portion of drug absorbed through the sublingual blood vessels avoids hepatic first‐pass metabolic processes giving good bioavailability. Sublingual technology for patients need enhanced lifecycle management to convenient dosing forgeriatric, pediatric and patient with dysphagia. This review highlights the introduction of sublingual drug delivery,mechanism ,factors affecting sublingual absorption, advantages, disadvantages,methods of preparation(tablet,films),drug administered by this route and conclusion.


Keywords: Improved bioavailability, Sublingual delivery, Dysphagia, Technique.

Downloads

Download data is not yet available.

Author Biographies

Sanjana Labhade, MET’s Bhujabal Knowledge City, Institute of Pharmacy, Adgaon, Nashik-422003, India

MET’s Bhujabal Knowledge City, Institute of Pharmacy, Adgaon, Nashik-422003, India

Chaitali Malode, MET’s Bhujabal Knowledge City, Institute of Pharmacy, Adgaon, Nashik-422003, India

MET’s Bhujabal Knowledge City, Institute of Pharmacy, Adgaon, Nashik-422003, India

Vaishali Rawal, MET’s Bhujabal Knowledge City, Institute of Pharmacy, Adgaon, Nashik-422003, India

MET’s Bhujabal Knowledge City, Institute of Pharmacy, Adgaon, Nashik-422003, India

Smita Rupvate, MET’s Bhujabal Knowledge City, Institute of Pharmacy, Adgaon, Nashik-422003, India

MET’s Bhujabal Knowledge City, Institute of Pharmacy, Adgaon, Nashik-422003, India

References

1. Ishikawa T, Koizumi N, Mukai B. Pharmacokinetics of acetaminophen from rapidly disintegrating compressed tablet prepared using microcrystalline cellulose (PH‐M‐06) and spherical sugar granules. Chem Pharm Bull (Tokyo) 2001; 49:230‐32.
2. Price TM, Blauer KL, Hansen M, Stanczyk F, Lobo R, Bates GW.Single‐dose pharmacokinetics of sublingual versus oral administration of micronized 17 beta‐estradiol. Obstet Gynecol 1997; 89:340‐45.
3. R.P Walton Absorption of drugs through the oral mucosa. III Fat‐water solubility coefficient of alkaloids. Proc Soc Exp Bio Med 1935; 32: 1488
4. Richman MD, Fox D, Shangraw RF. Preparation and stability ofglyceryl trinitrate sublingual tablets prepared by direct compression. J Pharm Sci 1965; 54(3): 447‐451.
5. McElnay JC, Al‐Furaih TA, Hughes CM, Scott MG, Elborn JS, Nicholls DP. The effect of pH on the buccal and sublingual absorption of captopril. Eur J Clin Pharmacol 1995; 48(5):373‐379.
6. Richman MD, Fox D, Shangraw RF. Preparation and stability of glyceryl trinitrate sublingual tablets prepared by direct compression. J Pharm Sci 1965; 54(3): 447‐451.
7. McElnay JC, Al‐Furaih TA, Hughes CM, Scott MG, Elborn JS, Nicholls DP. The effect of pH on the buccal and sublingual absorption of captopril. Eur J Clin Pharmacol 1995; 48(5):373‐379.
8. Lea L. Sublingual Administration. Colon Health 1996; 13.
9. Boer D et al. Drug absorption by sublingual and rectal routes. British J Anaesthesia 1984; 56: 69‐82.
10. Katz M, Barr M. A study of sublingual absorption I. Several factors influencing the rate of adsorption. J Am Pharm Assoc Am Pharm Assoc (Baltim) 1955; 44(7): 419‐423.
11. Allen LV. Rapid‐dissolve technology: an interview Int J Pharm Technol 2003; 7:449‐450.
12. Fu Y, Yang S, Jeong SH, Kimura S, Park K. Orally fast disintegrating tablets: developments, technologies, tastemaking and clinical studies. Crit Rev Ther Drug Carrier Syst 2004; 21: 433‐476.
13. Weinberger M. Pharmacological management of Asthma. J Adolescent Health Care 1987; 8(1): 74‐83.
14. John DN, Fort S, Lewis MJ, Luscombe DK. Pharmacokinetics and pharmacodynamics of Verapamil following sublingual and oral administration to healthy volunteers. Br J Clin Pham 1992; 33: 623‐627
15. Sheeba FR. Formulation and evaluation of nifedipine sublingual tablets. Asian journal of pharmacy and clinical research 2009; 2(3): 41-48.
16. Jayasukh JH, Dhawal AR, Kantilal RV. Orally disintegrating tablets: A review. Tropical journal of pharmaceutical research, 2009; 8(2):161-172.
17. Lachman L, Liberman A, King JL. Tablets: the theory and practice of industrial pharmacy (3rdedition), Varghese publishing house, 1987; 296-300.
18. Indian Pharmacopoeia. Ministry of Health and Family Welfare, Govt. of India. The Controller of Publications. New Delhi.1996.
19. Bi Y, Sunada H, Yonezawa Y, Danjok, Otoska A, lida K. Prepration and evaluation of a compressed tablet rapidly disintegrating in the oral cavity. Chem Pharm Bull (Tokyo).1996; 44:212.y and clinical research 2009; 2(3):41-48.
20. Rameshwari S, Anandi J. formulation and evaluation of nifedipine sublingual tablets. Asian journal of pharmacy and clinical research 2009; 2(3):41-48.
21. Mukesh P Ratnaparkhi, Dr. GP Mohanta, , Dr. Lokesh Upadhyay. Review on : rapid dissolving tablets. Journal of pharmacy research, 2009; 2(1).
22. Jayasukh JH, Dhawal AR, Kantilal RV. Orally disintegrating A review. Tropical journal of pharmaceutical research, 2009; 8(2):161-172.
23. Lachman L, Liberman A, King JL. Tablets: the theory and practice of industrial pharmacy (3rdedition), Varghese publishing house, 1987; 296-300.
24. Indian Pharmacopoeia. Ministry of Health and Family Welfare, Govt. of India. The Controller of Publications. New Delhi.1996.
25. Ketan A.Mehta, Serpil Kislalioglu M et al. Multi-unit controlled release system of nifedipine and nifedipine: Pluronic® F-68 Solid dispersion: Characterization of release mechanisms, Drug Dev Ind Pharm.2002; 28 Suppl 3:275-285.
26. Bi Y, Sunada H, Yonezawa Y, Danjok, Otoska A, lida K. Prepration and evaluation of a compressed tablet rapidly disintegrating in the oral cavity. Chem Pharm Bull (Tokyo).1996; 44:212.
27. Yunxia B, Sunada H, Yonezawa Y and Danjok. Evaluation of rapid disintegrating tablets prepared by direct compression method, Drug. Dev.Ind.Pharm. 25(5), 1999,571.
28. Prashant M, satturwar S, Fulzele V and avinash K. dorle. AAPS Pharmscitech.2005; 6(4):48-53.
29. Renuka Mishra, Avani Amin. Pharmaceutical Technology. Feb 2, 2009; 33(2):48-56.
30. Edmund J. Preparation, characterization and scale of ketoconazole with enhanced dissolution and bioavailability. Drug Dev Ind Pharm 2007; 33:755-76
Statistics
1 Views | 4 Downloads
How to Cite
Labhade, S., Malode, C., Rawal, V., & Rupvate, S. (2019). Review on Sublingual Drug Delivery System. Journal of Drug Delivery and Therapeutics, 9(3), 684-688. https://doi.org/10.22270/jddt.v9i3.2684