Design, Characterization and In-vitro Evaluation of Superporous Hydrogel Tablets of Nimodipine
Abstract
The present work was aimed to formulate Superporous Hydrogel tablets of Nimodipine using an effervescent approach for gastro retentive drug delivery system to improve its bioavailability by using different rate retarding polymers like plantago ovata, tamarind gum and carbopol, along with suitable excipients. All the formulations were prepared by direct compressionmethod. The prepared tablets of all the formulations were evaluated for physical characteristics, in‐vitro drug release, hardness and friability. Optimized formulation F8 containing 0.3% of plantago ovata and carbopol each was considered as the best formulation with respect to in vitro drug release for 12 hours release action. The results showed that the drug release rate was decreased as the viscosity of the polymer was increased. The drug release kinetics was performed for the optimized formulation and it shows zero orderwith non-fickian transport drug release.
Keywords: Superporous Hydrogel tablets, Nimodipine, plantago ovata, tamarind gum and carbopol, non-fickian transport drug release.
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