Nanosuspension: An emerging trend to improve solubility of poorly water soluble drugs
There are various parameters like solubility, stability, compatibility, excipient, and photostability which affects formulation of drugs, but solubility plays an important role for drug formulation. Most of newly discovered drugs are poorly water soluble. The poor water solubility of drugs always create major problem during drug formulation. There are many conventional techniques available for increasing the solubility of poorly soluble drugs such as micronization, solubilisation using co‐solvents, salt form, precipitation technique etc. Other newer methods are also available such as liposomes, emulsions, microemulsion, solid dispersion but they lack in general applicability to all drugs. These techniques are not applicable for those drugs which are not soluble in aqueous and organic solvents. Poorly water-soluble compounds are difficult to develop as drug products using conventional formulation techniques. Nanotechnology is emerging trend to develop the formulation of those drugs which are poorly water soluble. Nanotechnology involves particle size ranges from 1–1000 nm. The reduction of drug particle size into the submicron range automatically leads to increase in the dissolution rate and therefore enhances bioavailability. Nanosuspension technology is effective new way that can be used for enhancing the dissolution of poorly water soluble drugs. A nanosuspension solves the problems of poor solubility and bioavailability as well as alters the pharmacokinetics of drug and this will improve drug safety and efficacy. Another additional feature of nanosuspensions is that they may induce changes in the crystalline structure, increasing the amorphous fraction in the particle or even sometimes creating completely amorphous particles.
Keywords: Nanotechnology, Solubility, Nanosuspension, methods, bioavailability
2. Prasanna Lakshmi, Giddam Ashwini Kumari, Nanosuspension Technology: A Review, International Journal of Pharmacy and Pharmaceutical Sciences, 2010; 2(4).
3. Jaiswal P, Kesharwani S, Kesharwani R, Patel D, Ethosome: A New Technology Used As Topical & Transdermal Delivery System. Journal of Drug Delivery and Therapeutics, 2016; 6(3):7-17.
4. Sneha B. Garasiya, Nanosupension: an attempt to enhance the bioavailability of poorly water soluble drugs, International journal of advances in pharmacy, Biology and Chemistry, vol. 2012; 1(1),
5. Shah DP, Patel B, Shah C, Nanosuspension technology: A innovative slant for drug delivery system and permeability enhancer for poorly water soluble drugs, Journal of Drug Delivery and Therapeutics, 2015; 5(1):10-23
6. Roshan Kumar B., Nikitha I., Shiva Sharma, Nishikant D, Rishi T., Nanosuspension: A review, Research & Reviews: Journal of Journal of Pharmaceutics and Nanotechnology, 2016; Special Issue 2,
7. Geetha G, Poojitha U, Khan KAA, Various Techniques for Preparation of Nanosuspension- A Review, International Journal of Pharma Research & Review, Sept 2014; 3(9):30-37 ISSN: 2278-6074
8. Patravale VB, Date AA, Kulkarni RM, Nanosuspensions: a promising drug delivery strategy, Journal of pharmacy and pharmacology JPP 2004, 56: 827–840_ 2004
9. Kalvakuntla S, Deshpande M, Attari Z, Koteshwara K B. ,Preparation and Characterization of Nanosuspension of Aprepitant by H96 Process, Adv Pharm Bull, 2016; 6(1):83-90 doi:15171/apb.2016.013
10. Sahu BP, Das MK, Nanosuspension for enhancement of oral bioavailability of felodipine, ApplNanosci (2014; 4:189–197, DOI 10.1007/s13204-012-0188-3
11. Yong Li, Xiuhua Zhao, Yuangang Zu, Yin Zhang, Preparation and characterization of paclitaxel nanosuspension using novel emulsification method by combining high speed homogenizer and high pressure homogenization, International Journal of Pharmaceutics 2015; 490:324–333
12. P. Kocbek, S. Baumgartner, J. Kristl, University of Ljubljana, Preparation and evaluation of nanosuspensions for enhancingthe dissolution of poorly soluble drugs, International Journal of Pharmaceutics 2006; 312:179–186
13. Nangare KA, Powar SD, Kate VK, Patwekar SR And Payghan SA, Therapeutics Applications of Nanosuspension in Topical/ Mucosal Drug Delivery, Journal of Nanomedicine Research, 2018; 7(1).
14. Prajapati S, Maurya S, Das M, Tilak V, Verma K, & Dhakar R. Dendrimers in Drug Delivery, Diagnosis and Therapy: Basics and Potential Applications. Journal of Drug Delivery and Therapeutics, 2016; 6(1):67-92.
15. Nilesh Jain, Ruchijain, Navneet Thakur, Brahmprakash Gupta, Deepak Kumar Jain, Jeethendra Banveer, Surendra Jain, Nanotechnology: A Safe And Effective Drug Delivery System, Asian Journal of Pharmaceutical and Clinical Research, 2010 ; 3(3),
16. Mitesh Patel, Arpit Shah, Dr. N.M. Patel, Dr. M.R. Patel, Dr. K.R. Patel, Nanosuspension: A Novel Approach For Drug Delivery System, Journal of pharmaceutical science and bioscientific research, Volume 1, Issue 1: July-August 2011; 1-10.
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