Estimation of Labetalol Hydrochloride in bulk and formulation by UV-Spectrophotometric Area Under Curve.
Abstract
The current work was carried out for estimation of labetalol hydrochloride in bulk and pharmaceutical dosage form by utilizing area under curve method (AUC) method .For this purpose the wavelength range 200-400 nm was selected .Distilled Water was used as a solvent throughout the work. The linearity was observed in concentration range 5-25 µg/ml (r2 =0.9788) for the method. The present was found which can be used for routine quality control analysis for spectrophotometric estimation of labetalol hydrochloride in bulk and dosage form.
Keywords: Labetalol hydrochloride, Area under curve (AUC), Distilled Water, UV Spectrophotometric.
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References
1) https://pubchem.ncbi.nlm.nih.gov/compound/Labetalol_hydrochloride.
2) https://en.wikipedia.org/wiki/Labetalol
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2) https://en.wikipedia.org/wiki/Labetalol
3) Michael E. Swartz, Ira S. Krull, Analytical method development and validation, Marcel Dekker, Inc., 1997; 17: 25-2.
4) Christian G.D, John Wiley and Sons, Analytical chemistry, sixth edition 2003; 1-2,604- 620.
5) Beckett, A. H., Stenlake, J. B., Practical Pharmaceutical Chemistry, 4th edition, CBS Publishers and Distributors, New Delhi, 2002; 2: 275-295.
6) Saravanan V, Revathi R, Meera N, Method Development and Validation for the Simultaneous Estimation of Lycopene and Ubidecarenone By RP-HPLC in Combined Pharmaceutical Dosage Form. Journal of Drug Delivery and Therapeutics, 2016; 6(5):46-51.
7) ICH Harmonised Tripartite Guideline: Validation of analytical procedures: text and methodology Q2 (R1).
8) Pachpute Karishma and Jadhav S.L, Estimation of Disulfiram in Bulk and Formulation by UV- Spectrophotometric Area Under Curve method, Inventi Rpid:Pharma Analyis & Quality Assurance 2019; 2.
9) Chordiya Bhakti, Patel S G, Dhobale S M. Estimation of Pazufloxacin Mesylate in bulk and formulation by UV- Spectrophotometric area under Curve Method, Int. Ref. J. of Science and Enginerring, 2018 A3:193-198
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How to Cite
1.
Suryawanshi AD, Dhobale SM, Abhang SR, Patel SG. Estimation of Labetalol Hydrochloride in bulk and formulation by UV-Spectrophotometric Area Under Curve. JDDT [Internet]. 15May2019 [cited 14Apr.2021];9(3):168-70. Available from: http://jddtonline.info/index.php/jddt/article/view/2633
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