Estimation of Metformin Hydrochloride in Bulk and Formulation by UV - Spectroscopic Area Under Curve Method

  • Vrushali B Kakade Vishal Institute of Pharmaceutical Education and Research, Ale, Tal- Junnar, Dist- Pune, (412411) Maharashtra, India
  • G.A. Lobhe Vishal Institute of Pharmaceutical Education and Research, Ale, Tal- Junnar, Dist- Pune, (412411) Maharashtra, India
  • Snehal G. Gandhat Vishal Institute of Pharmaceutical Education and Research, Ale, Tal- Junnar, Dist- Pune, (412411) Maharashtra, India
  • S. M., Dhobale Vishal Institute of Pharmaceutical Education and Research, Ale, Tal- Junnar, Dist- Pune, (412411) Maharashtra, India
  • Salim G. Patel Vishal Institute of Pharmaceutical Education and Research, Ale, Tal- Junnar, Dist- Pune, (412411) Maharashtra, India

Abstract

The current work is carried out for estimation of Metformin Hydrochloride   by using area under curve (AUC) method using UV-visible spectrophotometer. For this purpose the wavelength range 221-241 nm was selected. Distilled water was used as a solvent throughout the work. Linearity was observed in concentration range 5-25 µg/ml (R2= 0.994) for the method. The present method was found to be simple and linear which can be used for routine quality control analysis for spectrophotometric estimation of Metformin hydrochloride in bulk.


Keywords: Metformin Hydrochloride, Area under curve, Antidiabetic, λmax.

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Author Biographies

Vrushali B Kakade, Vishal Institute of Pharmaceutical Education and Research, Ale, Tal- Junnar, Dist- Pune, (412411) Maharashtra, India

Vishal Institute of Pharmaceutical Education and Research, Ale, Tal- Junnar, Dist- Pune, (412411) Maharashtra, India

G.A. Lobhe, Vishal Institute of Pharmaceutical Education and Research, Ale, Tal- Junnar, Dist- Pune, (412411) Maharashtra, India

Vishal Institute of Pharmaceutical Education and Research, Ale, Tal- Junnar, Dist- Pune, (412411) Maharashtra, India

Snehal G. Gandhat, Vishal Institute of Pharmaceutical Education and Research, Ale, Tal- Junnar, Dist- Pune, (412411) Maharashtra, India

Vishal Institute of Pharmaceutical Education and Research, Ale, Tal- Junnar, Dist- Pune, (412411) Maharashtra, India

S. M., Dhobale, Vishal Institute of Pharmaceutical Education and Research, Ale, Tal- Junnar, Dist- Pune, (412411) Maharashtra, India

Vishal Institute of Pharmaceutical Education and Research, Ale, Tal- Junnar, Dist- Pune, (412411) Maharashtra, India

Salim G. Patel, Vishal Institute of Pharmaceutical Education and Research, Ale, Tal- Junnar, Dist- Pune, (412411) Maharashtra, India

Vishal Institute of Pharmaceutical Education and Research, Ale, Tal- Junnar, Dist- Pune, (412411) Maharashtra, India

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How to Cite
Kakade, V. B., Lobhe, G., Gandhat, S. G., Dhobale, S. M., & Patel, S. G. (2019). Estimation of Metformin Hydrochloride in Bulk and Formulation by UV - Spectroscopic Area Under Curve Method. Journal of Drug Delivery and Therapeutics, 9(3), 163-167. https://doi.org/10.22270/jddt.v9i3.2632