Pre-Liposomes: A novel drug delivery system
Preliposomes are a novel drug delivery system (NDDS). Preliposomes, due to their various forms, require further exploration. These structures can deliver both hydrophilic and hydrophobic drugs for cancer, bacterial infections, fungal infections, immunomodulation, diagnostics, ophthalmic, vaccines, enzymes and genetic elements. Prevesicular drug delivery system like preliposomes having distinct advantages over conventional drug delivery system. These systems overcome the problems associated with instability of liposomes. preliposomes composed of water-soluble porous powder as carrier which having ability to rapid hydration of preliposomes and formed vesicles. New concept of demonstrating preliposomes as novel carrier to enhance the oral bioavailability and permeation across the membrane. On the basis of investigation. it is clear that pre-liposomes are the alternate drug carrier for the various route of administration. These reviews give the brief knowledge about the preparation, evaluation and application of prevesicular drug delivery system in pharmaceutical field. The current deepening and widening of liposome interest in many scientific disciplines and their application in pharmaceutics, cosmetics and food industries as promising novel breakthroughs and products are also handle. The obtained information allows establishing criteria for selecting pre-liposomes as a drug carrier according to its advantages and limitations.
Keywords: Novel drug delivery, Liposomes, Lamellar, Carrier
2. Jain SK, Jain NK, Liposomes as Drug Carriers. In: Jain NK Controlled and Novel Drug Delivery. 6th ed. New Delhi: CBS Publication; 2008. P. 304-345.
3. Chen Y. et. al., Enhanced bioavailability of the poorly water-soluble drug fenofibrate by using liposomes containing bile salt: International journal of pharmaceutics, 2009; 367:153-160.
4. Xu H. et al., Optimized preparation of vinpocetine preliposomes by a novel method and in vivo evaluation of its pharmacokinetics in New Zealand rabbits: Journal of Control Release, 2009; 16:61-68.
5. Deshmukh DD, Ravis WR, Betageri GV, Improved delivery of cromolyn from oral preliposomes beads: International Journal of Pharmacy, 2008; 358:128-136.
6. Gupta V, Barupal AK, Ramteke Formulation development and in vitro characterization of preliposomes for topical aelivery of aceclofenac: Indian Journal of Pharmaceutics and science, 2008; 70(6):768-775.
7. Hiremath PS, Soppimath KS, Betageri GV, Preliposomes of exemestane for improved oral delivery, Formulation and in vitro evaluation using pampa Caco-2 and rat intestine: International Journal of Pharmaceutics, 2009; 96:104-380.
8. Vyas S P, Khar R K, Targeted and controlled drug delivery (Novel carrisers systems). 7th ed Delhi: CBS publishers and distributors; 2006. P. 173-181.
9. Gupta V Barupal, A K Ramteke S, Formulation development and in vitro characterization of preliposomes for topical delivery of Aceclofenac: Indian Journal of Pharma Science, 2008; 70(6):6875.
10. Nalla P, Bagam S, Eedara BB, Dhurke R, Formulation and Evaluation of Domperidone Oral Preliposomes Powders: International Journal of Pharmatech Research, 2015; 7:108-118.
11. Yadav AV, Murthy MS, Shete AS, Sakhare S, Stability Aspects of Liposomes: Indian Journal of Pharma Education and Research, 2011; 45(4):402-413.
12. Dua J S, Rana A C, Bhandari A K, Liposome: methods of preparation and applications: International Journal of Pharmaceutical Study Research, 2012; 3:14-20.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (SeeÂ The Effect of Open Access).