Formulation and Development OF BCS Class II Drug
The aim of this research was to develop and evaluate liquisolid compacts of Voriconazole a BCS class II drug. The series of formulations containing Voriconazole drug were formulated by using aerosil a colloidal silicone dioxide and avicel PH microcrystalline cellulose in different ratios by using suitable solvent. Solubility studies were performed in propylene glycol and polyethylene glycol (PEG-200, 400, 600) for the choice of the best non volatile liquid to dissolve Voriconazole. On the basis of the solubility data PEG 600 was chosen as a good solvent for the Voriconazole. Voriconazole was dissolved in solvent PEG 600 for the preparation of solution of drug. Formulated compacts were evaluated for all post compression parameters and the in-vitro drug release study was carried out. All the formulations have shown a very good drug release in 15 min except compressibility problems due to higher loading factor of liquid vehicle for the formulations. The selected formulation FV10 containing 30% of drug solution has shown good drug release of 100.2.% in 15 min compared to dissolution of pure drug and marketed tablet which shown 58.5.5% and 70..6 % respectively.No interactions were found between drug and polymers in FITR as well as DSC. XRD of selected formulation shows that drug present in the formulation is in amorphous form.
Keywords: Voriconazole HCl, Avicel PH, Aerosil 200, Poly-Ethylene Glycol 600, liquisolid compacts.
2. Chella Naveen., Nalini Shastri., Rama Rao Tadikonda., Use of the liquisolid compact technique for improvement of the dissolution rate of valsartan. Acta Pharmaceutica Sinica B; 2012; 2(5):502–508.
3. Fahmy RH., Kassem MA., Enhancement of famotidine dissolution rate through liquisolid tablets formulation: in-vitro and in-vivo evaluation. Eur J Pharm Biopharm.; 2008; 69(3):993-1003.
4. Ramesh J., Vijaya kumar B, Narasimha Reddy Y, Formulation and evaluation of olanzapine liquisolid compact tablets, IJPT; 2016; 8(2):11780-11789.
5. Arulkumaran J., Padmapreetha., Enhancement of solubility of Voriconazoleby liquisolid technique. International Journal of Pharmaceutical Chemistry and Analysis; 2014; 1(1):14-38.
6. Kaur M, Bala R, Arora S, Formulation and evaluation of liquisolid compacts of amlodipine besylate.IRJP; 2013; 4(1).
7. Sandhya P., Shadab Khanam., Bhatnagar D, Rao Patnaik KSK, Subrahmanyam CVS, Formulation and Evaluation of Liquisolid Compacts of Carvedilol. IOSR Journal of Pharmacy and Biological Sciences; 2013; 6(5):26-36.
8. Jamakandi VG, Kerur SS, Patil US, Formulation and Evaluation of Immediate Release Tablet of Carvedilol using Liquisolid Compacts Technique for Solubility Enhancement. Asian journal of Pharmaceutics. 2016; 10(3).
9. Javadzadeh Y, SiahiShadbad MR, BarzegarJalali M, Nokhodchi A,.Enhancement of dissolution rate of piroxicam using liquisolid compacts.Farmaco: 2005; 60(4):361-5
10. Yousef javadzadeh., Mohammad reza siahi., Solmaz asnaashari., Ali nokhodchi. Liquisolid technique as a tool for enhancement of poorly water-soluble drugs and evaluation of their physicochemical properties. Acta Pharm.; 2007; 57:99–109.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).