Formulation and optimization of carbamazepine floating tablets by 23 - factorial design employing Starch-Urea-Borate: A new floating polymer
Several approaches are currently used to retain the dosage form in the stomach. These include bioadhesive systems, swelling and expanding systems, floating systems and other delayed gastric emptying devices. The principle of floating tablets offers a simple and practical approach to achieve increased gastric residence time to enhance the bioavailability and to obtain controlled release. Floating tablets are designed based on gas generating principle. Design of floating tablets needs a strong matrix forming polymer. Though several polymers are available for floating tablets, there is a continued need to develop new, effective and efficient polymers for controlled release floating tablets. The major objective of the investigation is to evaluate starch-urea-borate, a new modified starch as a floating matrix former in the design of controlled release floating tablets.
Keywords: Optimisation, Carbamazepine, Starch-Urea-Borate, Floating Tablets
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