PEGylated liposome containing sildenafil for the treatment of hypertension

  • Jaiprakash Sharma Department of Pharmacy, Banasthali Vidyapith, Rajasthan, India
  • Sarvesh Paliwal Department of Pharmacy, Banasthali Vidyapith, Rajasthan, India
  • Swapnil Sharma Department of Pharmacy, Banasthali Vidyapith, Rajasthan, India
  • Vivek Dave Department of Pharmacy, Banasthali Vidyapith, Rajasthan, India

Abstract

The purpose of this study was to prepare PEGylated liposomes containing sildenafil for the treatment of pulmonary arterial hypertension. PEGylated liposomes were prepared by thin film hydration method by varying the concentration of lipids. The prepared liposomes were characterized for the particle size, PDI, zeta potential, % entrapment efficiency and in-vitro release study. The optimized formulation exhibits a particle size of 104.27±1.4 nm, PDI of 0.449±0.02, zeta potential of -42.9±0.7 along with the maximum encapsulation of drug i.e. 87.30±2.6. Optimized formulation showed % cumulative drug release of 85.38±0.26 in 48 hr.  From the study it can be concluded that the PEGylated liposomes containing sildenafil for the treatment of pulmonary arterial hypertension provides a sustained release of drug and further studies are required to confirm their efficacy at clinical level.


Keywords: Sildenafil; PEGylated liposomes; Pulmonary arterial hypertension; % entrapment efficiency

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Author Biographies

Jaiprakash Sharma, Department of Pharmacy, Banasthali Vidyapith, Rajasthan, India

Department of Pharmacy, Banasthali Vidyapith, Rajasthan, India

Sarvesh Paliwal, Department of Pharmacy, Banasthali Vidyapith, Rajasthan, India

Department of Pharmacy, Banasthali Vidyapith, Rajasthan, India

Swapnil Sharma, Department of Pharmacy, Banasthali Vidyapith, Rajasthan, India

Department of Pharmacy, Banasthali Vidyapith, Rajasthan, India

Vivek Dave, Department of Pharmacy, Banasthali Vidyapith, Rajasthan, India

Department of Pharmacy, Banasthali Vidyapith, Rajasthan, India

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How to Cite
Sharma, J., Paliwal, S., Sharma, S., & Dave, V. (2019). PEGylated liposome containing sildenafil for the treatment of hypertension. Journal of Drug Delivery and Therapeutics, 9(2-s), 462-465. https://doi.org/10.22270/jddt.v9i2-s.2568