Formulation, development and evaluation of Microsponge loaded Topical Gel of Nystatin

  • Ashwini S Bansode
  • Vaishnavi B Kute
  • Komal S Vethekar
  • Priyanka S Kote
  • Monika K Varhadi
  • Ajit S Bansode
  • Suresh L Jadhav
  • Nitin V Devhadrao

Abstract

Nystatin containing microsponge as active constituent (API) in different formulations by changing the proportions of drug (Nystatin), polymer (ethyl cellulose), emulsifier (Poly vinyl alcohol) were obtained successfully using quasi-emulsion solvent diffusion method. These formulations were studied for particle size and physical characterization. Scanning electron microscopy (SEM) images showed the microsponges porous and spherical in shape. The physical characterization showed that microsponge formulation coded by P6 showed a better loading efficiency and production yield. This microsponge formulation was prepared as gel in carbopol and studied for pH, viscosity, spreadability, drug content, in-vitro release. The microsponge formulation gel, F3 showed viscosity3465.84cps,spreadability of 26.22g cm/s and drug content of 89.65%. The nystatin microsponge gel formulations showed an appropriate drug release profile. F3 released 81.03% of drug at 12 hours.


Keywords: Microsponge, Solvent diffusion method, Scanning electron microscope, Nystatin microsponge gel.

Downloads

Download data is not yet available.

References

1. Nokhodchi A, Jelvehgari M, Siahi MR, Mozafari MR. Factors affecting the morphology of benzoyl peroxide microsponges. Micron 2007; 38:834–840.
2. Orlu M, Cevher E, Araman A. Design and evaluation of colon specific drug delivery system containing flurbiprofen microsponges. Int. J. Pharm. 2006; 318:103-117.
3. Emanuele AD, Dinarvand R. Preparation, characterization and drug release From thermo responsive microspheres, Int. J. Pharm.; 1995, 237-242.
4. Jones DS, Pearce KJ. Investigation of the effects of some process variables on, microencapsulation of propranolol HCl by solvent evaporation method. Int. J.Pharm. 1995; 118:99-205.
5. Vyas SP, Khar RK, Targeted and Controlled Drug Delivery-Novel Carrier System: New Delhi: CBS Publication, 2002, p. 453-95.
6. Nacht V. Katz M. The microsponge: a novel topical programmable delivery system, in: D.W. Osborne, A.H. Amman (Eds.), Topical Drug Delivery Formulations, Marcel Dekker: New York, Basel; 1990:299-325.
7. Patel G, Patel JK. Use of a Microsponge in Drug Delivery Systems. Available from:URL:http:www.pharmpro.com/ShowPR.aspx?PUBCODE=021&ACCT=0000100&ISSUE=0602&RELTYPE=PR&ORIGRELTYPE=ATO&PROCODE=0 000&PRODLETT=B&CommonCount=0.
8. Garg R., Kumar S, Gupta G. Topical Gel: A Review, http://www.pharmainfo.net. 2008,63.
9. Sharma S, Goswami J, Gupta G, Mustafa A, Topical Drug Delivery Systems: A Review, http://www.pharmainfo.net. 2008.6 (5).
10. Banker, Rhodes P. Modern Pharmaceutics. edited by Gilberts Banker, Mercel Dekker, New York, 4thEdn 2000,189-191.
11. Howard C, Nicholas G., Ointments, creams and gels. In: Pharmaceutical dosage forms and drug delivery system. in editors loyd V. Allen , Nicholas,G.popovich, Howard C Ansel 7thEdn, New Delhi ,2000, 2.44-250
12. Waugh A, Grant A, Ross and Wilson. Anatomy & Physiology in Health & Illness. Elsevier Science Ltd , 9thEdn . New York, 2003 361-372.
13. Jain A, Gautam S, Gupta Y, Khambete H, Jain S. Development and characterization of ketoconazole emulgel for topical drug delivery. Pelagia Research Library. 2010; 1:221-231.
14. Lachman L, Lieberman HA, Kanig JL. The Theory and Practice Of Industrial Pharmacy..Varghese Publishing House, 3rd Ed. Bombay; 1987:293-345
15. Laithy HM. and El shaboury KMF. Thedevelopment of CutinaLipogels and gelmicroemulsion for topical administration offluconazole. AAPS PharmSciTech. 2003; 3:25.
16. Eccleston GM. Emulsions. In: Swarbrick J, Boylan JC, eds.Encyclopedia of Pharmaceutical Technology,: Marcel Dekker Inc; New York 1992:137-188.
17. Clyde MO, Cathy MK. Gels and Jellies., In Swarbrick J, Boylan JC, editors. Encyclopedia of Pharmaceutical Technology. Marcel Dekker. 3rdEdn. New York. 1875-1889. 2007
18. Mohamed M I, Optimization of Chlorphen esinEmulgel Formulation. AAPS PharmSciTech. 2004, 6:26.
19. Vijaya Bhanu P, Shanmugam V,Lakshmi PK, Development And Optimization Of Novel Diclofenac EmulgelFor Topical Drug Delivery International Journal Of Comprehensive Pharmacy 2011, 9(10).
20. Kappor D., Patel M., Vyas R., Lad C., & Tyagi B. A review on microsponge drug delivery system. Journal of Drug Delivery and Therapeutics, 2014; 4(5):29-35.
21. Khullar R , Kumar D, Seth N, Saini S. Formulation and evaluation of mefenamic acid emulgel for topical delivery. Saudi Pharmaceutical Journal. 2012; 20:63-67
22. Jelvehgari M, Siahi-Shadbad M.R., Azarmi S., Gary P.Martin, Ali Nokhodchi. The microsponge delivery system of benzoyl peroxide preparation, characterization and release studies. International Journal of Pharmaceutics, 2006; 308:124–132.
23. Orlu M, Cevher E, Araman A. Design and evaluation of colon specific drug delivery system containing flurbiprofen microsponges. Int. J. Pharm. 2006; 318: 103-117.
24. Jelvehgari M, Siahi-Shadbad M.R., Azarmi S., Gary P. Martin, Ali Nokhodchi. The microsponge delivery system of benzoyl peroxide preparation, characterization and release studies. International Journal of Pharmaceutics, 2007; 308:124–132.
25. Nacht V. Katz M. The microsponge: a novel topical programmable delivery system, in: D.W. Osborne, A.H. Amman (Eds.), Topical Drug Delivery Formulations, Marcel Dekker: New York, Basel; 1990: 299-325.
26. Madan M, Bajaj A, Amrutiya N. Formulation and in vitro evaluation of topical emulgel containing combination of a local anaesthetic and an anti-inflammatory drug. Indian Journal of Pharmaceutical Education and Research. 2009; 43:351.
27. Mehta M, Panchal A, Shah VH, Upadhyay Uprepared and evaluated controlled release microsponge gel for topical delivery of Clotrimazole International Journal of Biopharmaceutics. 2013; 4(3):225-230.
28. Quiñones D., Ms; Evone S. Ghaly., Formulation and characterization of Nystatin gel. PRHSJ 2008; 27(1):61-67.
29. Kaur R., Kaur S. Role of Polymers in Drug Delivery. Journal of Drug Delivery and Therapeutics, 2014; 4(3):32-36.
30. Chandramouli Y., Shaik F., RajalakshmiR.,Yasmeen R.B. Preparation and evaluation of microsponge loaded controlled release topical gel of acyclovir sodium. International Journal of Biopharmaceutics. 2012; 3(2): 96-102.
31. Raymond C., Paul J., Paul J. W. Handbook of Pharmaceutical Excipients.5thedition.Published by Pharm. press. New York; 2006.P.89, 90,159,160,317-322,622-624.
32. Indian Pharmacopoeia: Controller of Publications, Govt. of India, Ministry of
33. Health & Family Welfare, New Delhi, vol.1, 1996:7: 511-513
34. Indian Pharmacopoeia: Government of India, Ministry of Health & Family welfare, New Delhi, Vol. 1, 2007: 134
35. Jagdale S. C. Jadhav V. N, Chabukswar A. N, Kuchekar B. S, Solubility enhancement, physicochemical characterization and formulation of fast-dissolving tablet of Nifedipine-Betacyclodextrin complexes, Brazilian Journal of Pharmaceutical Sciences 2012: vol. 48, jan./mar:131-145.
36. Patil A, Madgulkar A.Surface Morphology and Drug Release Studies on Repaglinide Controlled Release Pellets Prepared by Solution Layering Method with Blend of PEG - HPMC - EC Polymers .Pharma Tutor article.2010.
37. Jaiswal, P., Kesharwani S., Kesharwani R., Patel D. Ethosome: A New Technology used as Topical & Transdermal Delivery System. Journal of Drug Delivery and Therapeutics, 2016; 6(3):7-17.
38. Rastogi V., Shukla S., Singh R., Lal N., & Yadav P. Microspheres: A Promising Drug Carrier. Journal of Drug Delivery and Therapeutics, 2016; 6(3):18-26.
39. Bhatt P, Gananaranjan G. Emulgel :A novel formulation approach for topical delivery of Hydrophobic drugs.IRJP,2013 4(2).
40. Panwar AS, Upadhyay N, Emulgel: A Review asian Journal Of Pharmacy And Life Science July-Sept, 2011; 1(3).
Statistics
20 Views | 22 Downloads
How to Cite
Bansode, A. S., Kute, V. B., Vethekar, K. S., Kote, P. S., Varhadi, M. K., Bansode, A. S., Jadhav, S. L., & Devhadrao, N. V. (2019). Formulation, development and evaluation of Microsponge loaded Topical Gel of Nystatin. Journal of Drug Delivery and Therapeutics, 9(2-s), 451-461. https://doi.org/10.22270/jddt.v9i2-s.2567