Design, optimization and evaluation of aceclofenac fast dissolving tablets employing starch glutarate: A new superdisintegrant

  • Rada Santosh Kumar GITAM Institute of Pharmacy, GITAM (Deemed to be University)GITAM Institute of Pharmacy, GITAM (Deemed to be University), Rushikonda, Visakhapatnam, A.P 530045, INDIA
  • T. Naga Satya Yagnesh GITAM Institute of Pharmacy, GITAM (Deemed to be University), Rushikonda, Visakhapatnam, A.P 530045, INDIA
DOI https://doi.org/10.22270/jddt.v9i2.2564

Abstract

In solid dosage forms, fast dissolving tablets has proven the best way for ease of administration for the pediatrics and geriatric patients. The current study involves in the evaluation of starch glutarate as a superdintegrant in the formulation of fast dissolving tablets of poorly soluble drugs employing 23factorial design. Starch glutarate was synthesized by esterification process. The synthesized starch glutarate was subjected to physical and micromeritic evaluation. To establish as starch glutarate as a superdisintegrant, fast dissolving tablet of aceclofenac was prepared employing starch glutarate in different proportions in each case by direct compression method employing 23 factorial design. All fast dissolving tablets prepared were evaluated for drug content, hardness, friability, disintegration time and other dissolution characteristics like percent dissolved in 5 min (PD5), Dissolution efficiency in 5 min (DE5%) and first order rate constant (K1). The starch glutarate prepared was found to be fine, free flowing amorphous powder. Starch glutarate exhibited good swelling in water. Fourier transform infrared spectra (FTIR) and Differential scanning calorimetry (DSC) study indicated the absence of interaction between aceclofenac and starch glutarate. All the fast dissolving tablets formulated employing starch glutarate were of good quality with regard to drug content (100±5%), hardness (3.6–4 kg/sq. cm), and friability (0.12-0.15%). The optimized formulation F8 has the least disintegration time i.e., 30±0.02s. The in vitro wetting time was less (i.e., 90s) in optimized formulation F8. The cumulative drug dissolved in the optimized formulation F8 was found to be 99.15±0.56% in 15 min. Starch glutarate was found to be a superdisintegrant which enhanced the dissolution efficiency when combined with crospovidone, croscarmellose sodium, with the aceclofenac and hence it could be used in the formulation of fast dissolving tablets to provide immediate release of the contained drug within 15 minutes.


Keywords: Fast dissolving, Superdisintegrant, Starch glutarate, Dissolution efficiency.

Downloads

Download data is not yet available.

Author Biographies

Rada Santosh Kumar, GITAM Institute of Pharmacy, GITAM (Deemed to be University)GITAM Institute of Pharmacy, GITAM (Deemed to be University), Rushikonda, Visakhapatnam, A.P 530045, INDIA

GITAM Institute of Pharmacy, GITAM (Deemed to be University), Rushikonda, Visakhapatnam, A.P 530045, INDIA

T. Naga Satya Yagnesh, GITAM Institute of Pharmacy, GITAM (Deemed to be University), Rushikonda, Visakhapatnam, A.P 530045, INDIA

GITAM Institute of Pharmacy, GITAM (Deemed to be University), Rushikonda, Visakhapatnam, A.P 530045, INDIA

References

1. Suresh B, Rajender KM, Ramesh G, Yamsani MR. Orodispersible tablets: An overview. Asian J Pharm 2008; 2:2-11.
2. Seager H. Drug delivery product and zydis-fast dissolving dosage form. J Pharm Pharmacol 1998; 50:375-82.
3. Abdelbary G, Prinderre P, Couani C, Taochim J, Reynier JP, Riccerelle P. The preparation of orally disintegrating tablets using a hydrophilic waxy binder. Int J Pharm 2004; 278(2):423-33.
4. Sastry SV, Nyshadham JR, Fix JA. Recent technological advances in oral drug delivery: a review. Pharm Sci Techol Today 2000; 3(4):138-45.
5. Lachman L, Libermann HA, Kanig JL. The theory and practice of industrial pharmacy. 3rdedition; 1991. p. 233-5.
6. Biradar S, Bhagavati S, Kuppasad I. Fast dissolving drug delivery system: A brief overview. Internet J Pharmacol 2005; 4:2. edition; 1991. p. 233-5.
7. Indurwade NH, Rajyaguru TH, Nakhat PD. Noval approach-fast dissolving tablets. Indian Drug 2002; 38(8):405-9.
8. The United States Pharmacopoeia 29, National Formulary 24, Asian Edition. Rockville, MD: United States Pharmacopoeia Convention, Inc; 2006. p. 1890.
9. Jacob S, Shirwaikar A, Joseph A, Srinivasan KK. Novel co-processed excipient of mannitol and microcrystalline callous for preparing fast dissolving tablet of Glipizide. Indian J Pharm Sci 2007; 69(5):633-9.
10. Hiremath JG, Shastry CS, Srinath MS. Pharmaceutical approaches of taste masking in oral dorage forms. Indian Drugs 2004; 41:253-7.
11. Abdelbary A, Elshafeey AH, Zidan G. Comparative effects of different cellulosic-based directly compressed orodispersible tablets on oral bioavailability of famotidine. Carbohydrate Polymers 2009; 77:799-806.
12. Battu SK, Michael AR, Soumyajit M, Madhusudan Y. Formulation and evaluation of rapidly disintegrating fenoverine tablets: effect of super disintegrants. Drug Dev Ind Pharm 2007; 33:1225-32.
13. Goel H, Vora N, Rana V. A novel approach to optimize and formulate fast disintegrating tablets for nausea and vomiting. AAPS PharmSciTech 2008; 9:774–8.
14. Puttewar TY, Kshirsagar MD, Chandewar AV, Chikhale RV. Formulation and evaluation of orodispersible tablet of taste masked doxylamine succinate using ion exchange resin. J King Saud University (Sci) 2010; 22:229–40.
15. Manohara P, Trivikrama bhatlu M, Kiran kumar P V, Bala krishna N, Murali krishna Ranga. Formulation and evaluation of aceclofenac fast disintegrating tablets in the design Hordeum Vulgare Hull. Journal of Pharmacy Research 2012; 5:657-660.
Statistics
384 Views | 311 Downloads
How to Cite
1.
Santosh Kumar R, Satya Yagnesh TN. Design, optimization and evaluation of aceclofenac fast dissolving tablets employing starch glutarate: A new superdisintegrant. JDDT [Internet]. 15Mar.2019 [cited 9Aug.2022];9(2):259-6. Available from: http://jddtonline.info/index.php/jddt/article/view/2564
Issue
Vol 9 No 2 (2019): Volume 9, Issue 2 March-April 2019
Section
Research
Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).