Herbal mediated silver nanoparticles: A new horizon of antineoplastic drug delivery system
Cancer is a disease characterized by the uncontrolled growth and spread of abnormal cells, and is still the second most common cause of death worldwide. Several classes of drugs are available to treat different types of cancer. Currently, researchers are paying significant attention to the development of drugs at the nanoscale level to increase their target specificity and to reduce their side effects. Silver nanoparticles are the topics of researchers because of their distinctive properties (e.g., size and shape and electrical properties). Synthesis of herbal mediated silver nanoparticles targeting biological pathways has become tremendously prominent due to the higher efficacy and fewer side effects as compared to other commercial cancer drugs. A variety of preparation techniques have been reported for the synthesis of silver nanoparticles such as physical, chemical and biological methods. In this review, different medicinal plants and their active compounds, as well as synthesized silver nanoparticles from medicinal plants, are discussed in relation to their anticancer activities.
Keywords: Silver nanoparticles, Medicinal plants and Anti-cancer activities.
2. Dilip Kumar Chanchal , Shashi Alok,, Surabhi Rashi,, Rohit Kumar Bijauliya, RahulDeoYadav and Monika Sabharwal. Various Medicinal Plants Used In the Treatment of Anticancer Activity, IJPSR. 2018; 9(4):65 - 74.
3. Shiji Mathew, AnaghaPrakash and E. K. Radhakrishnan, Sunlight mediated rapid synthesis of small size range silver nanoparticles using Zingiber officinale rhizome extract and its antibacterial activity analysis. Inorganic and Nano-Metal Chemistry. 2018: 48(5):1 – 12.
4. Wiratchanee Mahavorasirikul, Vithoon Viyanant, Wanna Chaijaroenkul, Arunporn Itharat and Kesara Na-Bangchang. Cytotoxic activity of thai medicinal plants against human cholangiocarcinoma, laryngeal and hepatocarcinoma cells in vitro. BMC Complementary & Alternative Medicine. 2010; 10 (5):1 – 8.
5. Gwang Hun Park, Jae Ho Park, Hun Min Song, Hyun Ji Eo, Mi Kyoung Kim, Jin Wook Lee, Man Hyo Lee, Kiu-Hyung Cho, Jeong Rak Lee, Hyeon Je Cho and Jin Boo Jeong, Anti-cancer activity of Ginger (Zingiber officinale) leaf through the expression of activating transcription factor 3 in human colorectal cancer cells, The official journal of the International Society for Complementary Medicine Research. 2014: 14:408; 1472 – 1482.
6. Ninh The Son. Notes on the genus Paramignya: Phytochemistry and biological activity. Bulletin of Faculty of Pharmacy, Cairo University. 2018; 56 (1):1-10.
7. Nguyen VT, Sakoff JA, Scarlett CJ, Physicochemical Properties, Antioxidant and Anti-proliferative Capacities of Dried Leaf and Its Extract from Xao tam phan. Biotechnol Adv. 2017; 32(4):10 – 18.
8. Amrinder Singh and Kaicun Zhao, Chapter Five - Treatment of Insomnia With Traditional Chinese Herbal Medicin. International Review of Neurobiology. 2017; 135:97-115.
9. Lei Bi, Xiaojing Yan, Ye Yang, Lei Qian, Yuan Tian, Jian-Hua Mao, and Weiping Chen. The component formula of Salvia miltiorrhiza and Panax ginseng induces apoptosis and inhibits cell invasion and migration through targeting PTEN in lung cancer cells. Oncotarget Open Access Impact Journal. 2017; 8(60):101599-101613.
10. NatalyAbrams, Danay Rodriguez, HollieCanacari, Talal El-Hefnawy, Diana Schultz, Fort Myers. Aloe Emodin’s Effects on Apoptosis in Cervical Cancer Cells, Aquila - The FGCU Student Research Journal. 2014; 50 (5):25-36.
11. Hussain A, Sharma C, Khan S, Shah K, Haque. Aloe vera inhibits proliferation of human breast and cervical cancer cells and acts synergistically with cisplatin. Asian Pac J Cancer Prev. 2015: 16:2939-46.
12. Yen Chu Chen and BingHuei Chen. Preparation of curcuminoidmicroemulsions from Curcuma longa. L to enhance inhibition effects on growth of colon cancer cells HT-29. Royal Society of Chemistry Advances. 2018; 8:2323-2337.
13. ShunsukeKimura, AkikoKiriyamaKaekoAraki, MaiYoshizumib, MasakazuEnomurab, DaisukeInouec. Novel strategy for improving the bioavailability of curcumin based on a new membrane transport mechanism that directly involves solid particles. European Journal of Pharmaceutics and Biopharmaceutics. 2018; 122:1-5.
14. Md. ZubayerHossainSaad, RaunakJahan, UddhavBagul. Nanopharmaceuticals: A New Perspective of Drug Delivery System. Asian Journal of Biomedical and Pharmaceutical Sciences. 2012; 2 (14):25 – 37.
15. Alyssa B. Chinen, Chenxia M. Guan, Jennifer R. Ferrer, Stacey N. Barnaby, Timothy J. Merkel, and Chad A. Mirkin. Nanoparticle Probes for the Detection of Cancer Biomarkers, Cells, and Tissues by Fluorescence, Chem. Rev. 2015; 115 (19):10530–10574.
16. Ankush Sharma, AmitK. Goyal and Gowtam Rath. Recent advances in metal nanoparticles in cancer therapy. Journal of Drug Targeting. 2017; 2:32 – 40.
17. Prashant Kesharwani, UmeshGuptha. Nano Technology Based Targeted Drug Delivery Systems For Brain Tumors. Bulletin of Faculty of Pharmacy, Cairo University. 2018; 56(5);56 -69.
18. Saba Hasan. A revive on nanoparticles; their synthesis and types. Research Journal of Recent Sciences. 2015; 4:1-3.
19. Avnika Tomar and GarimaGarg. Short Review on Application of Gold Nanoparticles. Global Journal of Pharmacology. 2013: Vol. 7 (1); 34-38.
20. Kh.S.Mekheimera, W.M.Hasonab, R.E.Abo-Elkhaira, A.Z.Zaherc. Peristaltic blood flow with gold nanoparticles as a third grade nanofluid in catheter: Application of cancer therapy. Physics Letters A. 2018; 382 (3):85-93.
21. Oliviero L. Gobbo, Kristine Sjaastad,Marek W. Radomski,Yuri Volkov, and AdrielePrina Mello. Magnetic Nanoparticles in Cancer Theranostics. NCBI. 2015; 5(11):1249–1263.
22. Gamze Kuku and Mustafa Culha. Investigating the Origins of Toxic Response in TiO2 Nanoparticle-Treated Cells. Nanomaterials (Basel). 2017; 7(4):83.
23. NafeesaKhatoon, Jahirul Ahmed Mazumder and MeryamSardar. Biotechnological Applications of Green Synthesized Silver Nanoparticles. Journal of Nanosciences: Current Research. 2017; 5 (5);52-63.
24. Elham Safarzadeh, SiamakSandoghchianShotorbani, and BehzadBaradaran. Herbal Medicine as Inducers of Apoptosis in Cancer Treatment. Adv Pharm Bull. 2014; 4:421–442.
25. Renu Sankar, Arunachalam Karthik, Annamalai Prabu, Selvaraju Karthik, Kanchi Subramanian, VilwanathanRavikumar. Origanumvulgare mediated biosynthesis of silver nanoparticles for its antibacterial and anticancer activity, Biointerfaces. 2013; 108(1):80-84.
26. Rijuta G. Saratale, HanSeung Shin, Gopalakrishnan Kumar, Giovanni Benelli, Dong-Su Kim & Ganesh D. Saratale. Exploiting antidiabetic activity of silver nanoparticles synthesized using Punicagranatum leaves and anticancer potential against human liver cancer cells (HepG2). Journal Artificial Cells, Nanomedicine, and Biotechnology An International Journal. 2018; 46 (1):211-222.
27. Mehdi Dadashpour, Akram Firouzi Amandi, Mohammad Pourhassan- Moghaddam, Mohammad, JafarMaleki, Narges Soozangar, FarhadJeddi, Mohammad Nouri,Nosratollah Zarghami, Younes Pilehvar-Soltanahmadi. Biomimetic synthesis of silver nanoparticles using Matricariachamomilla extract and their potential anticancer activity against human lung cancer cells. Materials Science and Engineering. 2018; 92 (1):902-912.
28. Hussaina Banu, N. Renuka, S.M. Faheem, Raees Ismail, Vinita Singh, Zahra Saadatmand, Saad Sultan Khan, Kavya Narayanan, Alma Raheem, Kumpati Premkumar and Geetha Vasanthakumar. Gold and Silver Nanoparticles Biomimetically Synthesized Using Date Palm Pollen Extract-Induce Apoptosis and Regulate p53 and Bcl-2 Expression in Human Breast Adenocarcinoma Cells. Biological Trace Element Research. 2018; 382 (3):85-93.
29. Humboldt. Fundamental growth principles of colloidal metal nanoparticles – a new perspective. Royal Society of Chemistry. 2015; 6 (3):399–408.
30. Chetna Dhand, Neeraj Dwivedi, Xian Jun Loh, Alice Ng Jie Ying, Navin Kumar Verma, Roger W. Beuerman, Rajamani Lakshminarayanan and Seeram Ramakrishna. Methods and strategies for the synthesis of diverse nanoparticles and their applications: a comprehensive overview. RSC Advances. 2015; 7 (1):34-38.
31. Alexander and Bulavchenko. Synthesis and Concentration of Organosols of Silver Nanoparticles Stabilized by AOT: Emulsion Versus Microemulsion. Langmuir. 2018; 34 (8):2815-2822.
32. Wanzhong Zhang, Xueliang Qiao, Jianguo Chen. Synthesis and characterization of silver nanoparticles in AOT microemulsion system. Chemical Physics. 2006; 330 (3):495-500.
33. Valeria De Matteis, MariafrancescaCascione, Chiara Cristina Toma and Stefano Leporatti. Silver Nanoparticles: Synthetic Routes, In Vitro Toxicity and Theranostic Applications for Cancer Disease. Nanomaterials. 2018; 8(5):319.
34. Shintaro Ueno, Kouichi Nakashima,Yasunao Sakamotoand Satoshi Wada. Synthesis of Silver-Strontium Titanate Hybrid Nanoparticles by Sol-Gel-Hydrothermal Method. Nanomaterials. 2015; 5(2):386-397.
35. S. Iravani H. Korbekandi S.V. Mirmohammadi and B. Zolfaghari. Synthesis of silver nanoparticles: chemical, physical and biological methods, Res Pharm Sci. 2014: Vol. 9(6): 385–406.
36. Alena Michalcová, Larissa Machado, Ivo Marek, Marek Martinec, Marcela Sluková, Dalibor Vojtěch. Properties of Ag nanoparticles prepared by modified Tollens' process with the use of different saccharide types. Journal of Physics and Chemistry of Solids. 2018: Vol. 113; 125-133.
37. Zhiyuan Leng, Dongrui Wu, Qinke Yang, Shichao Zeng, Weisheng Xia. Facile and one-step liquid phase synthesis of uniform silver nanoparticles reduction by ethylene glycol, Optik. International Journal for Light and Electron Optics. 2018: Vol. 154; 33-40.
38. Kruis, F. Fissan, H. & Rellinghaus, B. Sintering and evaporation characteristics of gas-phase synthesis of size-selected PbS nanoparticles. Mater Sci Eng B. 2000; 69:329-324.
39. Kim M, Osone, S Kim, T, Higashi H, Seto, T. Synthesis of nanoparticles by laser ablation: A review. KONA Powder Part. J. 2017; 32 (5):80–90.
40. Muhammad rafique, Iqrasadaf, MShahidrafique and M. Bilal tahir. A review on green synthesis of silver nanoparticles and their applications. Artificial Cells, Nanomedicine, and Biotechnology. 2017; 45 (7):325 – 336.
41. Lakshmanan G, Sathiyaseelan A, Kalaichelvan P.T., Murugesan K. Plant-mediated synthesis of silver nanoparticles using fruit extract of Cleome viscosa L.: Assessment of their antibacterial and anticancer activity. Karbala International Journal of Modern Science. 2018: Vol. 4(1); 61-68.
42. Sangiliyandi Gurunathan, Jung Hyun Park, Jae Woong Han, and Jin-Hoi Kim. Comparative assessment of the apoptotic potential of silver nanoparticles synthesized by Bacillus tequilensis and Calocybe indica in MDA-MB-231 human breast cancer cells: targeting p53 for anticancer therapy, Int J Nanomedicine. 2015; 10:4203–4223.
43. Jayachandran Venkatesan, Jin-Young Lee, Dong Seop Kang, Sukumaran Anilc Se-Kwon Kim, Suk Shima Dong Gyu Kim. Antimicrobial and anticancer activities of porous chitosan-alginate biosynthesized silver nanoparticles. International Journal of Biological Macromolecules. 2017; 98:515-525.
44. Sathishkumar P, Vennila K, Jayakumar R, Yusoff ARM, Hadibarata T. Phyto-synthesis of silver nanoparticles using Alternanthera tenella leaf. Bioprocess Biosyst Eng,E pub. 2016; 39(4):651-659.
45. T. Venkata Rajesh Kumar, J. S. R. Murthy, Madamsetti Narayana Rao, Y. Bhargava. Evaluation of silver nanoparticles synthetic potential of Couroupita guianensis Aubl., ﬂower buds extract and their synergistic antibacterial activity. Journal of Biotech. 2016; 6:92 – 98.
46. Arun S. Sonker, Richa, Jainendra Pathak, Rajneesh, Vinod K. Kannaujiya and Rajeshwar P. Sinha. Characterization and in vitro antitumor, antibacterial and antifungal activities of green synthesized silver nanoparticles using cell extract of Nostoc sp. strain HKAR-2. Canadian Journal of Biotechnology. 2017; 4 (2);26-37.
47. Waghmare M, Khade B, Chaudhari P, Dongre P. Multiple layer formation of bovine serum albumin on silver nanoparticles revealed by dynamic light scattering and spectroscopic techniques. Journal of Nanoparticle Research, 2018; 20; 185 – 196.
48. Anandalakshmi K, Venugobal J, Ramasamy V. Characterization of silver nanoparticles by green synthesis method using Pedalium murex leaf extract and their antibacterial activity. Applied Nanoscience. 2016: Vol. 6 (3); 399 - 408.
49. Ping Chang Lin, Stephen Lin, Paul C Wang and Rajagopalan Sridhar. Techniques for physicochemical characterization of nanomaterials. Biotechnol Adv. 2014; 32 (4):1 – 13.
50. Zhou M, Wei Z, Qiao H, Zhu L, Yang H, Xia. Particle Size and Pore Structure Characterization of Silver Nanoparticles Prepared by Confined Arc Plasma. Journal of Nanomaterials. 2009; Vol. 2009:1 - 5
51. Baisakhi Moharana, Preetha, Selvasubramanian, Malathi and Balasubramanian. Synthesis and Characterization of Pectin Capped Silver Nanoparticles and Exploration of Its Anticancer Potentials In Experimental Carcinogenesis In Vitro. Indo American Journal of Pharmaceutical Research. 2014; 4(2):26-37.
52. Ana-Alexandra Sorescu, Rodica-Mariana Ion, Şuică-Bunghez Ioana. Green synthesis of silver nanoparticles using plant extracts. The 4th International Virtual Conference on Advanced Scientific Results, 2016: www.scieconf.com.
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