Process variable studies for preparation of optimized system for bupropion hydrochloride using CCD

  • Aparna Gupta Shri Ram Murti Smarak College of Engineering & Technology, (Pharmacy), Bareilly, Uttar Pradesh
  • Vijay Sharma Faculty of Pharmacy, IFTM University, Moradabad, Uttar Pradesh
  • Lalit Singh Faculty of Pharmacy, IFTM University, Moradabad, Uttar Pradesh

Abstract

Aim of present work is to develop optimized sustained release dosage form of Bupropion hydrochloride using Formulation by Design (FbD) approach. Development and optimization of formulation batches was done by design experiment using Central Composite Design (CCD). Tablets were formulated by direct compression technique and evaluated. The impact of independent variables like concentration of Hydroxypropyl Methyl Cellulose (HPMC K4M) and  Carbopol (CP 934P) were observed on  dependent variable like hardness of tablet, drug release in 12 h (Q12h) and the time for fifty percent release of drug (T50%). Polynomial equations were generated using multiple linear regression analysis (MLRA), response surface plots and contour plots were drawn, optimum formulations were selected by brute force method. The hardness and Q12h was found in the range of 4.4- 4.7 Kg/cm2 and 88.19- 96.7% respectively, while T50% was found in the range of 3.5- 5.5h. Validation of optimization study performed using four confirmatory experimental runs which indicated very high degree of prognostic ability of FbD methodology with percentage error varied between -0.024% and 0.024 %. The overlaying of all these plots provided an overlay plot, which signified the region of optimization. Thus, central composite design (CCD) is a useful tool in the development of optimized dosage form along with the significance of independent variable as well as least investment of money, manpower and time.


Keywords: Formulation by Design, Central Composite Design, Bupropion Hydrochloride.

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Author Biographies

Aparna Gupta, Shri Ram Murti Smarak College of Engineering & Technology, (Pharmacy), Bareilly, Uttar Pradesh

Shri Ram Murti Smarak College of Engineering & Technology, (Pharmacy), Bareilly, Uttar Pradesh

Vijay Sharma, Faculty of Pharmacy, IFTM University, Moradabad, Uttar Pradesh

Faculty of Pharmacy, IFTM University, Moradabad, Uttar Pradesh

Lalit Singh, Faculty of Pharmacy, IFTM University, Moradabad, Uttar Pradesh

Faculty of Pharmacy, IFTM University, Moradabad, Uttar Pradesh

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How to Cite
Gupta, A., Sharma, V., & Singh, L. (2019). Process variable studies for preparation of optimized system for bupropion hydrochloride using CCD. Journal of Drug Delivery and Therapeutics, 9(2-s), 281-290. https://doi.org/10.22270/jddt.v9i2-s.2513