Formulation and Characterization of Alginate Microbeads of Clonidine Hydrochloride by Ionotropic Gelation Technique

  • Rituraj Dubey Technocrats Institute of Technology-Pharmacy Education & Research, Bhopal (M.P.), India
  • B.K. Dubey Technocrats Institute of Technology- Pharmacy, Bhopal (M.P.), India
  • Girijesh Kumar Pandey Technocrats Institute of Technology-Pharmacy Education & Research, Bhopal (M.P.), India
  • S.K. Yadav Technocrats Institute of Technology-Pharmacy Education & Research, Bhopal (M.P.), India

Abstract

The objective of this study was to prepare and evaluate sodium alginate microbeads with calcium chloride as cross-linking agent for Clonidine hydrochloride by ionotropic gelation method. Clonidine hydrochloride a centrally acting sympatholytic and imidazoline-derivative hypotensive agent; selective α2-adrenergic agonist. It stimulates alpha2-adrenergic receptors in the brainstem to decrease sympathetic nervous system outflow. It is also administered epidurally to treat pain. Microbeads offer numerous advantages for releasing one of the drugs or part of the same drug immediately while remaining drug or parts of the same can be sustained release. Prepared microbeads were evaluated for particle size, polydispersity index, zeta potential, particle shape, surface morphology, entrapment efficiency and In vitro drug release. The prepared beads were free flowing and white in color. The drug loaded beads showed 72.9±2.4% to 94.6±2.6 % drug entrapment, which was found to increase with increase in alginate concentration. In vitro drug release study of these microbeads indicated controlled release for Clonidine hydrochloride 83.46% release after 48 hours. Hence the observations of all results of the different batches, MBD 11 showed controlled release action and improved drug availability. From this study it could be concluded that the free flowing microbeads of Clonidine hydrochloride could be successfully prepared by ionotropic gelation technique with high entrapment efficiency and prolonged release characteristics.


Keywords: Clonidine hydrochloride, Microbeads, Sodium alginate, Calcium chloride, Ionotropic gelation method.

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Author Biographies

Rituraj Dubey, Technocrats Institute of Technology-Pharmacy Education & Research, Bhopal (M.P.), India

Technocrats Institute of Technology-Pharmacy Education & Research, Bhopal (M.P.), India

B.K. Dubey, Technocrats Institute of Technology- Pharmacy, Bhopal (M.P.), India

Technocrats Institute of Technology- Pharmacy, Bhopal (M.P.), India

Girijesh Kumar Pandey, Technocrats Institute of Technology-Pharmacy Education & Research, Bhopal (M.P.), India

Technocrats Institute of Technology-Pharmacy Education & Research, Bhopal (M.P.), India

S.K. Yadav, Technocrats Institute of Technology-Pharmacy Education & Research, Bhopal (M.P.), India

Technocrats Institute of Technology-Pharmacy Education & Research, Bhopal (M.P.), India

References

1. Petersen K, SchmutzlerW. Proton pump inhibitors. Active substance release from different preparations. Deutsche Apotheker Zeitung, 1999; 139:64–65.
2. Pillay V, Fassihi R. In-vitro release modulation from cross linked pellets for site-specific drug delivery to the gastrointestinal tract: I. Comparison of pHresponsive drug release and associated kinetics. Journal of Controlled Release, 1999; 59(2):229-242.
3. Nagata K, Takagi E, Tsuda M. Inhibitory action of Lansoprazole and its analogs against helicobacter pylori: inhibition of growth is not related to inhibition of urease. AntimicrobialAgents and Chemotherapy, 1995; 39:567-70.
4. Florence A. The oral absorption of micro- and nanoparticulates: neither exceptional nor unusual. Pharmaceutical Research, 1997; 14:259–266.
5. Ulrich K, Matthias S. Topical delivery of therapeutic agents in the treatment of inflammatory bowel disease. Advanced Drug Delivery Review. 2005; 57(2):267-279.
6. Roy S, Das S.. Design and in-vitro evaluation of dapsone-loaded micropellets of ethyl cellulose. Pharmaceutical Research, 1989; 6(11):945-948.
7. DashevskyA, Kolter K, Bodmeier R. Compression of pellets coated with various aqueous polymer dispersions. International Journal of Pharmaceutics, 2004; 279:19–26.
8. Thassu D and Vyas SP. Drug Dev Ind Pharm. 1991; 17:561-576.
9. Wade A and Weller PJ. Handbook of Pharmaceutical Excipients. Washington, DC.American Pharmaceutical Publishing Association. 1994; 362-366.
10. Panigrahi L, Pattnaik S and Ghosal SK. AAPS PharmSciTech. 2005; 6:E167YE173.
11. Lym-Ly and Wan-LS, ‘Propranolol Binding in Calcium Alginate Beads’, Drug Develop. Indi. Pharm. 1997; 23(10):973- 980.
12. Manna A, Ghosh I, Goswami N, Ghosh LK.and Gupta BK. Design and evaluation of an oral controlled Release Microparticulate Drug Delivery system of Nimesulide by Ionotropic Gelation Technique and Statistical Optimization by Factorial Analysis, J Sci Ind.Res. 1999; 58(9):717-722.
13. Patil VB and Varsha B.Preparation and Evaluation of Sustained Release Nimesulide Microspheres prepared from sodium alginate’ Indian J Pharm Sci. 2001; 63(1):15-19.
14. David W. Fry, J. Courtland White, I. David Goldman Rapid separation of low molecular weight solutes from liposomes without dilution. Analytical Biochemistry 1978; 90(2):809-815.
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How to Cite
Dubey, R., Dubey, B., Pandey, G. K., & Yadav, S. (2019). Formulation and Characterization of Alginate Microbeads of Clonidine Hydrochloride by Ionotropic Gelation Technique. Journal of Drug Delivery and Therapeutics, 9(2-s), 271-275. https://doi.org/10.22270/jddt.v9i2-s.2510