Kidney injury molecule-1 and its diagnostic ability in various clinical conditions

  • M Vijayasimha Department of Medical Laboratory Technology, Amity Medical School, Amity University, Haryana, India.
  • R K Jha Department of Medical Laboratory Technology, Amity Medical School, Amity University, Haryana, India.

Abstract

Objectives: This review evaluates the diagnostic ability of Kidney Injury Molecule 1 (Kim-1) in various clinical conditions. 
Methods: We screened literature in electronic database from January 2016 to March 2016 by the words “Kidney Injury Molecule-1”or “Kim-1” and “Acute Kidney Injury”. Specific studies were selected for inclusion if they were published in English journals, in which Kim-1 was measured for diagnosis of various forms of Acute Kidney Injury in different articles. 


Results: There were eight articles which met the selection criteria for inclusion in our study. Compared to non acute kidney injury (AKI) patients, Kim-1 raised significantly in different forms of AKI patients.


Conclusions: Kidney Injury Molecule-1 is a new emerging urinary biomarker in the early detection of acute kidney injury and repair of kidney cells as well. Kim-1 can detect acute tubular necrosis, a useful marker for renal proximal tubular injury and it can restore morphological integration of kidney cells followed by ischemic injury. Kim-1 can detect nephrotoxic injury and injury caused by various drugs as well.


Keywords: Kidney injury Molecule, Acute Kidney Injury

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Author Biographies

M Vijayasimha, Department of Medical Laboratory Technology, Amity Medical School, Amity University, Haryana, India.

Department of Medical Laboratory Technology, Amity Medical School, Amity University, Haryana, India.

R K Jha, Department of Medical Laboratory Technology, Amity Medical School, Amity University, Haryana, India.

Department of Medical Laboratory Technology, Amity Medical School, Amity University, Haryana, India.

References

1. Bonventre, J.V. Dedifferentiation and proliferation of surviving epithelial cells in acute renal failure. J. Am. SocNephrol. 2003; 14:S55-S61.
2. Kelly, K.J., et al. Intercellular adhesion molecule-1 deficient mice are protected against renal ischemia. J. Clin. Invest. 1996; 97:1056-1063.
3. Thadhani, R., Pascual, M., Bonventre, J.V. Acute renal failure. N. Engl. J. Med. 1996; 334:1448-1460.
4. Henson, P.M., Hume, D.A. Apoptotic cell removal in development and tissue homeostasis.TrendsImmunol. 2006; 27:244-250.
5. Savill, J., Dransfield, I., Gregory, C., Haslett, C. A blast from the past: clearance of apoptotic cells regulates immune responses. Nat. Rev. Immunol. 2002; 2:965-975.
6. Duffield, J.S., Ware, C.F., Ryffel, B., Savill, J. Suppression by apoptotic cells defines tumor necrosis factor-mediated induction of glomerular mesangial cell apoptosis by activated macrophages.Am. J. Pathol. 2001; 159:1397-1404.
7. Ichimura, T., et al. Kidney injury molecule-1 (KIM-1), a putative epithelial cell adhesion molecule containing a novel immunoglobulin domain, is up-regulated in renal cells after injury. J. Biol. Chem. 1998; 273:4135-4142.
8. Kuo CY, Wu HK. Toward an integrated model for designing assessment systems: An analysis of the current status of computer-based assessments in science. ComputEduc, 2013; 68:388-403.
9. Han WK1, Bailly V, Abichandani R, Thadhani R, Bonventre JV: Kidney Injury Molecule-1 (KIM-1): a novel biomarker for human renal proximal tubule injury. Kidney Int. 2002; 62(1):237-44.
10. Yuzhao Zhou, Vishal S. Vaidya, Ronald P. Brown,et al: Comparison of Kidney Injury Molecule-1 and Other Nephrotoxicity Biomarkers in Urine and Kidney Following Acute Exposure to Gentamicin, Mercury, and Chromium: Toxicol. Sci. 2008; 101(1):159-170.
11. TakaharuIchimura, Joseph V. Bonventre et al: Immunoglobulin Domain, Is Up-regulated in Renal Cells after Injury. February 13, The Journal of Biological Chemistry, 1998 ; 273:4135-4142.
12. Takaharu Ichimura, Cheng Chieh Hung, et al: Kidney injury molecule-1: a tissue and urinary biomarker for nephrotoxicant-induced renal injury, American Journal of Physiology - Renal Physiology, 2004; 286(3):F552-F563
13. Vishal S. Vaidya, Victoria Ramirez, Takaharu Ichimura, et al: Urinary kidney injury molecule-1: a sensitive quantitative biomarker for early detection of kidney tubular injury, American Journal of Physiology - Renal Physiology 2006; 290(2):F517-F529
14. MM van Timmeren, MC van den Heuvel, et al: Tubular kidney injury molecule-1 (KIM-1) in human renal disease, Journal of pathology, 2007; 212(2):209–217,
15. Mirjan M. van Timmeren, Vishal S. Vaidya, Rutger M. van Ree et al: High Urinary Excretion of Kidney Injury Molecule-1 Is an Independent Predictor of Graft Loss in Renal Transplant Recipients. Transplantation. 2007; 84(12):1625–1630.
16. Won K. Han, Anwar Alinani, Chin Lee Wu. Et al: Human Kidney Injury Molecule-1 Is a Tissue and Urinary Tumor Marker of Renal Cell Carcinoma. JASN April 1, 2005; 16(4):1126-1134.
17. Won K. Han, Anwar Alinani, Chin Lee Wu. Et al: Human Kidney Injury Molecule-1 Is a Tissue and Urinary Tumor Marker of Renal Cell Carcinoma. JASN April 1, 2005; 16(4):1126-1134.
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How to Cite
Vijayasimha, M., & Jha, R. K. (2019). Kidney injury molecule-1 and its diagnostic ability in various clinical conditions. Journal of Drug Delivery and Therapeutics, 9(2-s), 583-585. https://doi.org/10.22270/jddt.v9i2-s.2499