Novel verdicts of nifedipine encapsulated with cyclodextrin in new-fangled form of microsponges
The fundamental approach for the microsponge technologies arises in solid dosage forms because they showing a promising technology for nifedipine drug in hypertension control. As nifedipine drug is chosen due to its hydrophobic nature second short half-life, third low remark in plasma concentration. Cyclodextrin-based microsponges with different polymer are novel finding in the microsphere technology, the crosslinking of polymers blends with respect to cyclodextrin will enhance the entrapment of nifedipine drug in the new-fangled form by emulsification solvent method and futher Lyophilization. The different microsponges batches are formulated the optimize batch was MN3 with angle of repose; 21.80 ± 0.63., Hausner ratio 1.132, Carrs index 0.132 and higher % drug content (80.5 ± 0.97 %). showed 99.41 ± 1.05 % drug release during 36 hr in vitro release . After that the stability data disclose superior drug retention of loaded nifedipine, besides consistent in vitro release pattern over a period of 90 days.
Keywords: Microsponges, Cyclodextrin, Polymers, Nifedipine
2. Alenezi A, Naito Y, Terukina T, Prananingrum W, Jinno Y, Tagami T, Jimbo R, Controlled release of clarithromycin from PLGA microspheres enhances bone regeneration in rabbit calvaria defects, Journal of biomedical materials research part b: applied biomaterials, 2018; 106(1): 201-208.
3. Bao TQ, Hiep NT, Kim YH, Yang HM, & Lee BT, Fabrication and characterization of porous poly (lactic-co-glycolic acid) PLGA microspheres for use as a drug delivery system. Journal of materials science, 2011; 46(8):2510-2517.
4. Comoglu T, Gonul N, Baykara T, The effects of pressure and direct compression on tabletting of microsponges. International journal of pharmaceutics,2002; 242(1-2):191-195.
5. Comoglu T, Gonul N, Baykara T, Preparation and in vitro evaluation of modified release ketoprofen microsponges. Il farmaco, 2003; 58(2): 101-106.
6. Shrivastavs S, Kumar D, Dubey CK, Singh SP, Khinchi MP, A review: microsponge-an effective drug delivery system. Asian journal of pharmaceutical research and development, 2017; 1-08.
7. Kumar PM, Ghosh A, Development and evaluation of silver sulfadiazine loaded microsponge based gel for partial thickness (second degree) burn wounds. European journal of pharmaceutical sciences, 2017; 96: 243-254.
8. Pavani V, Vinod M, Anantha P, Design, formulation and in vitro evaluation of microsponges based gel for topical delivery of ketoconazole. International journal of pharmaceutical sciences and research, 2017; 8(10): 4222-4229.
9. Loftsson T, Duchene D, Cyclodextrins and their pharmaceutical applications. International journal of pharmaceutics, 2007; 329(1-2): 1-11.
10. Wang, haoyi, et al. "Research on the rheological properties of cross-linked polymer microspheres with different microstructures." powder technology, 2018; 331:310-321.
11. Uekama K, Design and evaluation of cyclodextrin-based drug formulation. Chemical and pharmaceutical bulletin, 2004; 52(8): 900-915.
12. Hiremath SN, Raghavendra RK, Sunil F, Danki LS, Rampure MV, Swamy PV, Bhosale UV, Dissolution enhancement of gliclazide by preparation of inclusion complexes with β-cyclodextrin, Asian journal of pharmaceutics, 2014; 2(1).
13. Liu H, Cai X, Wang Y, Chen J, Adsorption mechanism-based screening of cyclodextrin polymers for adsorption and separation of pesticides from water, Water research, 2011; 45(11): 3499-3511.
14. Perumal D, Microencapsulation of ibuprofen and eudragit1 RS 100 by the emulsion solvent diffusion technique, Int j pharm, 2001; 218:1–11.
15. Staesse JA, Thijs L, Fagard F, Amery A, Once-daily antihypertensive treatment with calcium antagonists: utopia or reality?, Netherlands j med, 1995; 46:15-24.
16. Chandy T, Sharma CP, Chitosan beads and granules for oral sustained delivery of nifedipine: in vitro studies, Biomaterials 1992; 13:949–952.
17. Yang MS, Cui FD, You BG, Fan YL, Wang L, Yue P, Yang H, Preparation of sustained-release nitrendipine microspheres with eudragit RS and aerosil using quasi-emulsion solvent diffusion method. Int j pharm, 2003; 259:103–113.
18. Filipovic-grcic J, Becirevic-lacan M, Skalko N, Jalsenjak I, Chitosan microsheres of nifedipine and nifedipinecyclodextrin inclusion complexes, Int j pharm, 1996; 135:183-190.
19. Katikaneni PR, Upadrashta SM, Neau SH, Mitra AK, Ethylcellulose matrix controlled release tablets of a water-soluble drug, Int j pharm, 1995; 123:119-125.
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