A review on Nanocomposite Drug Delivery
Low aqueous solubility is the major problem come across the formulation development of new chemical entities as well as for the generic development. Supplementary than 40% New Chemical Entities developed in pharmaceutical industry are practically insoluble in water. Hence, there is a need for boosting the solubility and dissolution of such drugs. Enhancement of the solubility and dissolution of the practically insoluble drug was achieved by forming nanocomposites. Nanocomposities are formed by using synthetic polymers such as gelatin, chitosan, polyvinyl pyrollidone, carboxymethyl cellulose, etc. Selection of polymers was based on their surfactant and wetting properties. To check the solubility enhancement of drugs solubility studies is carried out. Nanocomposites are characterized by Fourier transform infrared spectroscopy, differential scanning calorimetry, X-ray diffraction studies, scanning electron microscopy and transmission electron microscopy. As the concentration of polymer in the composite increased the solubility and dissolution of poorly water soluble drug were enhanced. In end, new technology require substances showing novel properties and/or progressed performance in comparison to conventionally processed additives. In this context, nanocomposites are appropriate materials to meet the emerging needs bobbing up from medical and technologic advances.
Keywords: nanocomposites, polymers, synthesis.
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