Prunus armeniaca (apricot) and Mucuna pruriens (Konch) seeds improves the liver damage in albino rat exposed to nicotine

  • Varsha Raj Department of Pharmacy, Pharmacology Research Lab, IFTM University Moradabad, 244102, India
  • Arun Kumar Mishra Department of Pharmacy, Pharmacology Research Lab, IFTM University Moradabad, 244102, India
  • Amrita Mishra Department of Pharmacy, Pharmacology Research Lab, IFTM University Moradabad, 244102, India
  • Najam Ali Khan Department of Pharmacy, Pharmacology Research Lab, IFTM University Moradabad, 244102, India

Abstract

Prunus armeniaca (apricot) and Mucuna pruriens (Konch) both are the plant, which are extensively used as medicine in Indian traditional system from ancients, they are considered to increase the protective mechanism against ailments. Nicotine is the main copious components in smoking of cigarette and it is primarily metabolized inside the liver. The current study was performed to explore the role of ethanolic extract of Prunus armeniaca and Mucuna pruriens seed on nicotine induced lethality in rats. Animals are divided in to seven group of with each group (n=6) number of rats. Wistar rats (Group II, III, IV, VI and VIII) were administered with oral nicotine diluted with drinking water for 32 days, While (Group I) plain control was treated with drinking water concurrently, following 32 days Group III, IV were administered with two different concentration of ethanolic extract of Prunus armeniaca seed (200 mg/kg , 400 mg/kg) and Group V and VI  received ethanoilc extract of Mucuna pruriens seed at different doses (400 mg/kg, 800 mg/kg). Group II served as toxicity group (5mg/kg body weight of nicotine). Rats were sacrificed 24 hrs after last day of administration (40th day), the biochemical and histopathological parameter were studies. A significance increase in the activity of SGOT, SGPT, CRT, Total bile acid, LDL, ALP, TC, TG, TBL, DBL and decreased the activity of Albumin, TP and HDL in nicotine control group was observed. Group IV and Group VI, the ethanolic extract of Prunus armeniaca seed (400 mg/kg) and ethanolic extract of Mucuna pruriens seed (800 mg/kg) make the defensive effects which were found more considerable in rats. Thus the consequence was recommended that the Prunus armeniaca and Mucuna pruriens both were exert the protecting effects during nicotine induced hepatoxicity in rats.


Keywords Prunus armeniaca, Mucuna pruriens, nicotine, hepatotoxicity.

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Author Biographies

Varsha Raj, Department of Pharmacy, Pharmacology Research Lab, IFTM University Moradabad, 244102, India

Department of Pharmacy, Pharmacology Research Lab, IFTM University Moradabad, 244102, India

Arun Kumar Mishra, Department of Pharmacy, Pharmacology Research Lab, IFTM University Moradabad, 244102, India

Department of Pharmacy, Pharmacology Research Lab, IFTM University Moradabad, 244102, India

Amrita Mishra, Department of Pharmacy, Pharmacology Research Lab, IFTM University Moradabad, 244102, India

Department of Pharmacy, Pharmacology Research Lab, IFTM University Moradabad, 244102, India

Najam Ali Khan, Department of Pharmacy, Pharmacology Research Lab, IFTM University Moradabad, 244102, India

Department of Pharmacy, Pharmacology Research Lab, IFTM University Moradabad, 244102, India

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How to Cite
Raj, V., Mishra, A. K., Mishra, A., & Khan, N. A. (2019). Prunus armeniaca (apricot) and Mucuna pruriens (Konch) seeds improves the liver damage in albino rat exposed to nicotine. Journal of Drug Delivery and Therapeutics, 9(2-s), 138-143. https://doi.org/10.22270/jddt.v9i2-s.2474