Prophylactic Effect of Butea monosperma against Cisplatin-Induced Nephrotoxicity in Rats
Abstract
Cisplatin is an effective chemotherapeutic agent for solid tumors; however its use is limited by nephrotoxicity. The current study investigated the effect of Butea monosperma in cisplatin-induced nephrotoxicity and oxidative stress in rats. Kidneys have a vital role in the normal physiology of humans. Worldwide chronic kidney disease has become a major cause for disability and in worst circumstances leads to death. Major renal disorders occur due to diabetes and its complications termed as diabetic nephropathy (DN). The animals were divided into four groups of six rats each (n=6). The control group (Group 1) received 1%CMC, Group 2 received only cisplatin, a 7 days of extract of Butea monosperma (200 mg/kg bwt) pre-treatment was applied to the animals in Group 3 before administration of cisplatin; a 7 days of extract of Butea monosperma was performed following administration of cisplatin for the animals in Group 4. Cisplatin (6 mg/kg) was intraperitoneally injected as a single dose and extract of Butea monosperma (200 and 400 mg/kg bwt) was administered by gavage in 1%CMC. Biochemical and histopathological methods were utilized for evaluation of the nephrotoxicity. The concentrations of creatinine, uric acid and blood urine nitrogen, in plasma and levels of malondialdehyde and reduced glutathione as well as glutathione peroxidase and catalase activities were determined in kidney tissue. Administration of cisplatin to rats induced a marked renal failure, characterized with a significant increase in plasma creatinine and uric acid and Blood urea nitrogen. levels of rats received cisplatin alone were significantly different compared to control group but they had higher kidney malondialdehyde, and lower reduce glutathione concentrations, superoxide dismutase and catalase activities. Extract of B. monosperma administration produced amelioration in biochemical indices of nephrotoxicity in both serum and kidney tissues when compared to toxic inducer group; pre-treatment with extract of Butea monosperma being more effective. Results from this study indicated that the novel natural antioxidant extract of B. monosperma might have protective effect against cisplatin-induced nephrotoxicity and oxidative stress in rat.
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