Potential benefits of phytochemicals for treatment of hyperpigmentation

  • Harsimran Kaur Delhi Pharmaceutical Sciences and Research University, New Delhi, India
  • , Afsana Delhi Pharmaceutical Sciences and Research University, New Delhi, India
  • Geeta Aggarwal Department of Pharmaceutics, Delhi Institute of Pharmaceutical Sciences and Research, New Delhi
  • Manju Nagpal Chitkara College of Pharmacy, Patiala, Punjab, India


UV radiation (UV) is considered as a complete carcinogen as it is both a mutagen and a non-specific damaging agent. It is the most important risk factor for skin cancer and many other skin disorders like Hyperpigmentation. There is a need of long-term topical skin care treatments (both cosmetic and cosmeceutical) to address problems associated with hyperpigmentation. Synthetic depigmenting agents, such as hydroquinone, mequinol, although highly effective, can raise several safety concerns (for example, ochronosis, cataract, impaired wound healing, desquamation, and other local or systemic side effects) with long-term exposure. The benefits of phytochemicals and natural extracts offer opportunities to develop new formulations to treat pigmentation problems. Cosmeceuticals are topical cosmetic-pharmaceutical preparations containing active ingredients which improve the appearance of skin. Among cosmeceuticals, the phytochemicals have been known to have a multitude of cellular actions for various dermatological diseases. Plant-derived compounds and their effectiveness in the treatment of hyperpigmentation disorders (Melasma) are discussed.

Keywords: UV radiation, Hyperpigmentation, Phytochemicals, Cosmeceuticals


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Author Biographies

Harsimran Kaur, Delhi Pharmaceutical Sciences and Research University, New Delhi, India

Delhi Pharmaceutical Sciences and Research University, New Delhi, India

, Afsana, Delhi Pharmaceutical Sciences and Research University, New Delhi, India

Delhi Pharmaceutical Sciences and Research University, New Delhi, India

Geeta Aggarwal, Department of Pharmaceutics, Delhi Institute of Pharmaceutical Sciences and Research, New Delhi
Assistant Professor, Department of Pharmaceutics, Delhi Institute of Pharmaceutical Sciences and Research, New Delhi
Manju Nagpal, Chitkara College of Pharmacy, Patiala, Punjab, India

Chitkara College of Pharmacy, Patiala, Punjab, India


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Kaur H, Afsana , Aggarwal G, Nagpal M. Potential benefits of phytochemicals for treatment of hyperpigmentation. JDDT [Internet]. 15Mar.2019 [cited 5Jul.2022];9(2):420-7. Available from: http://jddtonline.info/index.php/jddt/article/view/2453